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Measurement and Correlation of Solubility of Gatifloxacin in 12 Pure Solvents from 273.15 K to 318.15 K

Cite this: J. Chem. Eng. Data 2019, 64, 2, 676–681
Publication Date (Web):January 14, 2019
https://doi.org/10.1021/acs.jced.8b00902
Copyright © 2019 American Chemical Society

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    Abstract

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    The solubility of gatifloxacin in 12 pure organic solvents (methanol, ethanol, n-propanol, n-butanol, isopropanol, acetone, butanone, acetonitrile, 1,4-dioxane, ethyl acetate, toluene, and N,N-dimethylformamide (DMF)) was obtained at temperatures from 273.15 K to 318.15 K. The results show that the solubility of gatifloxacin in those 12 pure solvents increases with increasing temperature. At a given temperature range, they gradually decrease in the following order: ethyl acetate (6.789 × 10–3, 298.15 K) > DMF (5.657 × 10–3, 298.15 K) > butanone (3.488 × 10–3, 298.15 K) > acetonitrile (2.811 × 10–3, 298.15 K) > n-butanol (2.246 × 10–3, 298.15 K) > acetone (1.766 × 10–3, 298.15 K) > 1,4-dioxane (1.288 × 10–3, 298.15 K) > n-propanol (0.922 × 10–3, 298.15 K) > ethanol (0.698 × 10–3, 298.15 K) > methanol (0.531 × 10–3, 298.15 K) > isopropanol (0.401 × 10–3, 298.15 K) > toluene (0.261 × 10–3, 298.15 K). The (KAT-LSER) model was applied to analyze the effect of the solute–solvent intermolecular interactions on the solubility in those pure solvents. Moreover, the obtained solubility data were correlated with the modified Apelblat equation and the λh equation. Between the experimental and calculated solubility data, the largest value of relative average deviations (RAD) was 0.77 × 10–2, and it is 0.15 × 10–4 for root-mean-square deviations (RMSDs). The results showed that the experimental values are in good agreement with the calculated values. The experimental solubility and the models in this study could be helpful in applications in the field of medicine.

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    Cited By

    This article is cited by 3 publications.

    1. Jianhong Gu, Hongyan Zhao, Hui Zou, Renjie Xu. Solubility and Model Correlation of Amprolium Hydrochloride in Pure Solvent at the Temperature Range of 273.15–313.15 K. Journal of Chemical & Engineering Data 2020, 65 (1) , 274-279. https://doi.org/10.1021/acs.jced.9b00999
    2. Jiaxin Wu, Renjie Xu, Jian Wang, Hongkun Zhao. Thermodynamic Solubility of Gatifloxacin in Nonaqueous Solvent Mixtures of N,N-Dimethylformamide Plus Isopropanol/Methanol/n-Propanol/Ethanol. Journal of Chemical & Engineering Data 2019, 64 (12) , 6071-6077. https://doi.org/10.1021/acs.jced.9b00930
    3. William Acree, James S. Chickos. Phase Transition Enthalpy Measurements of Organic Compounds. An Update of Sublimation, Vaporization, and Fusion Enthalpies from 2016 to 2021. Journal of Physical and Chemical Reference Data 2022, 51 (4) https://doi.org/10.1063/5.0081916

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