Solubility Determination and Modeling for Artesunate in Binary Solvent Mixtures of Methanol, Ethanol, Isopropanol, and Propylene Glycol + Water
- Renjie Xu*Renjie Xu*Phone: +86 514 87993918. Fax: +86 514 87994009. E-mail: [email protected]Guangling College, Yangzhou University, YangZhou, Jiangsu 225000, People’s Republic of ChinaMore by Renjie Xu
- ,
- Ting HanTing HanGuangling College, Yangzhou University, YangZhou, Jiangsu 225000, People’s Republic of ChinaMore by Ting Han
- ,
- Li ShenLi ShenGuangling College, Yangzhou University, YangZhou, Jiangsu 225000, People’s Republic of ChinaMore by Li Shen
- ,
- Jianguo ZhaoJianguo ZhaoGuangling College, Yangzhou University, YangZhou, Jiangsu 225000, People’s Republic of ChinaMore by Jianguo Zhao
- , and
- Xiang’an LuXiang’an LuGuangling College, Yangzhou University, YangZhou, Jiangsu 225000, People’s Republic of ChinaMore by Xiang’an Lu
Abstract
Artesunate is dissolved in an aqueous solution of several organic solvents (methanol, ethanol, isopropanol, and PG), and the mole fraction of artesunate is determined by the static method. When the system reaches equilibrium, the range of system temperature is 278.15–318.15 K and the pressure environment is 101.1 kPa. When the temperature is constant, the equilibrium mole fraction of artesunate is proportional to the mass percentage of organic solvents, and the relationship between artesunate solubility and temperature is the same as before under certain conditions of the organic solvent component. When the external conditions are the same, artesunate is more likely to dissolve in the ethanol + water mixture than in several other systems. Besides, three classical mixed solvent thermodynamic equations—Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, and Apelblat–Jouyban–Acree model—are applied to calculate the equilibrium mole fraction of artesunate. The maximum value of average relative deviations (ARD) obtained during the calculation is 0.83%. The experimentally measured data on artesunate has different general meanings for the expansion of application and production in the pharmaceutical field and provides theoretical data for its industrial production.
Cited By
This article is cited by 15 publications.
- Xiaotong Yang, Jidong Wang, Miao Ma, Dongxu Wang, Jinliang Wu, Zhong Zhao. Solubility Determination and Thermodynamic Correlation for Terbinafine Hydrochloride in Several Mono-solvents from 283.15 to 323.15 K. Journal of Chemical & Engineering Data 2023, 68 (5) , 1191-1205. https://doi.org/10.1021/acs.jced.2c00731
- Xiaotong Yang, Jidong Wang, Miao Ma, Yixin Qu. Determination and Modeling of Artesunate Solubility in 13 Pure Solvents at 283.15–323.15 K. Journal of Chemical & Engineering Data 2022, 67 (12) , 3734-3747. https://doi.org/10.1021/acs.jced.2c00482
- Degui Wu, Zhao Wang, Lina Zhou, Baohong Hou, Ling Zhou. Measurement and Correlation of the Solubility of Aspirin in Four Binary Solvent Mixtures from T = 283.15 to 323.15 K. Journal of Chemical & Engineering Data 2020, 65 (2) , 856-868. https://doi.org/10.1021/acs.jced.9b01057
- Kalyani Kodide, Prashanth Asadi, Jyothi Thati. Solubility and Thermodynamic Modeling of Sulfanilamide in 12 Mono Solvents and 4 Binary Solvent Mixtures from 278.15 to 318.15 K. Journal of Chemical & Engineering Data 2019, 64 (12) , 5196-5209. https://doi.org/10.1021/acs.jced.9b00411
- Narges Gheitasi, Amin Heidardokht Nazari, Ali Haghtalab. Thermodynamic Modeling and Solubility Measurement of Cetirizine Hydrochloride and Deferiprone in Pure Solvents of Acetonitrile, Ethanol, Acetic Acid, Sulfolane, and Ethyl Acetate and Their Mixtures. Journal of Chemical & Engineering Data 2019, 64 (12) , 5486-5496. https://doi.org/10.1021/acs.jced.9b00620
- Long Wang, Jingping Sun, Yuwei Hua, Li Xu, Guoji Liu. Measurement and Correlation of the Solubility of 2-Cyanoacetamide in 14 Pure Solvents and the Mixing Properties of Solutions. Journal of Chemical & Engineering Data 2019, 64 (4) , 1680-1692. https://doi.org/10.1021/acs.jced.8b01205
- Md. Mahbubul Haque Hasan, M. Mehedi Hasan Rocky, Md. Niamat Ullah, Muhammad A.R. Khan, Syeda Rahimon Naher, Shamim Akhtar. Molecular interaction in the binary mixtures of tetrahydrofuran and 1,4-dioxane with methanol. New UNIFAC-VISCO interaction parameters for cyclic ethers. Journal of Molecular Liquids 2023, 379 , 121618. https://doi.org/10.1016/j.molliq.2023.121618
- J. W. Bezuidenhout, M. Aucamp, N. Stieger, W. Liebenberg, R. K. Haynes. Assessment of Thermal and Hydrolytic Stabilities and Aqueous Solubility of Artesunate for Formulation Studies. AAPS PharmSciTech 2023, 24 (1) https://doi.org/10.1208/s12249-022-02490-8
- Alex Avdeef, Manfred Kansy. Predicting Solubility of Newly-Approved Drugs (2016–2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression. Journal of Solution Chemistry 2022, 51 (9) , 1020-1055. https://doi.org/10.1007/s10953-022-01141-7
- Yao Tong, Feiyan Shi, Wenhui Wang, Hongsheng Li, Shangru Zhai, Kai Wang, Qingda An. Experimental measurement and thermodynamic modelling of ethenzamide solubility in three binary solvent systems. The Journal of Chemical Thermodynamics 2021, 161 , 106553. https://doi.org/10.1016/j.jct.2021.106553
- Wanxin Li, Rong Xing, Yiting Zhu, Ali Farajtabar, Hongkun Zhao. Solvent effect, transfer property and preferential solvation of artesunate in aqueous co-solvent mixtures of some alcohols. Physics and Chemistry of Liquids 2021, 59 (3) , 454-466. https://doi.org/10.1080/00319104.2020.1732374
- Shengdi Guo, Xianxian Yao, Qin Jiang, Kuang Wang, Yuanying Zhang, Haibao Peng, Jing Tang, Wuli Yang. Dihydroartemisinin-Loaded Magnetic Nanoparticles for Enhanced Chemodynamic Therapy. Frontiers in Pharmacology 2020, 11 https://doi.org/10.3389/fphar.2020.00226
- Wei-Jie Ji, En-Fu Wang, Ming-Hui Qi. Determination and Data Correlation of Solubility of Sofosbuvir Polymorphs in Ethyl Acetate + Toluene and Methyl tert-Butyl Ether Binary Solvents at the Temperature Range from 268.15 to 308.15 K. Crystals 2020, 10 (3) , 209. https://doi.org/10.3390/cryst10030209
- Yao Tong, Hongsheng Li, Shangru Zhai, Kai Wang, Qingda An. Thermodynamic analysis and molecular dynamic simulation of the solubility of saccharin in three binary solvent mixtures. The Journal of Chemical Thermodynamics 2020, 141 , 105952. https://doi.org/10.1016/j.jct.2019.105952
- Long Wang, Jingping Sun, Yuwei Hua, Li Xu, Guoji Liu. Solubility behaviour and thermodynamic analysis of methyleneaminoacetonitrile in binary (ethanol + water, ethanol + 2-propanol, ethanol + n-butanol) solvents. The Journal of Chemical Thermodynamics 2019, 138 , 272-281. https://doi.org/10.1016/j.jct.2019.06.009