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Equilibrium Solubility, Model Correlation, and Solvent Effect of Indole-3-acetic Acid in Twelve Pure Solvents

  • Rongrong Li*
    Rongrong Li
    School of Pharmaceutical and Materials Engineering, TaiZhou University, Taizhou, Zhejiang 318000, PR China
    *Tel.: +86 576 88660353. E-mail: [email protected] (Rongrong Li)
    More by Rongrong Li
  • Shiyun Zhan
    Shiyun Zhan
    School of Pharmaceutical and Materials Engineering, TaiZhou University, Taizhou, Zhejiang 318000, PR China
    More by Shiyun Zhan
  • Gang Chen
    Gang Chen
    School of Pharmaceutical and Materials Engineering, TaiZhou University, Taizhou, Zhejiang 318000, PR China
    More by Gang Chen
  • Yanxian Jin
    Yanxian Jin
    School of Pharmaceutical and Materials Engineering, TaiZhou University, Taizhou, Zhejiang 318000, PR China
    More by Yanxian Jin
  • Binbin Yu
    Binbin Yu
    School of Pharmaceutical and Materials Engineering, TaiZhou University, Taizhou, Zhejiang 318000, PR China
    More by Binbin Yu
  • Jia Zhao
    Jia Zhao
    Industrial Catalysis Institute, Zhejiang University of Technology, Hangzhou 310014, PR China
    More by Jia Zhao
  • Deman Han*
    Deman Han
    School of Pharmaceutical and Materials Engineering, TaiZhou University, Taizhou, Zhejiang 318000, PR China
    *Tel.: +86 576 88660177. E-mail: [email protected] (Deman Han).
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  • , and 
  • Huajun Fan*
    Huajun Fan
    Department of Chemistry, Prairie View A&M University, Prairie View, Texas 77446, United States
    *Tel.: (936) 261-3111. E-mail: [email protected] (Huajun Fan).
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Cite this: J. Chem. Eng. Data 2019, 64, 4, 1802–1808
Publication Date (Web):March 13, 2019
https://doi.org/10.1021/acs.jced.8b01265
Copyright © 2019 American Chemical Society

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    Abstract

    Abstract Image

    The solid–liquid solubility of indole-3-acetic acid in pure methanol, ethanol, n-propanol, isopropanol, acetone, n-butanol, acetonitrile, chloroform, ethyl acetate, 1,4-dioxane, N,N-dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) was measured by using a isothermal saturation method. The determination temperature range is from 278.15 to 323.15 K. The order of solubility data from high to low was ethyl acetate > DMSO > DMF > n-butanol > acetone > isopropanol > 1,4-dioxane > n-propanol > ethanol > methanol > acetonitrile > chloroform. Two thermodynamic models (modified Apelblat equation and λh equation) were used to correlate the solubility values of indole-3-acetic acid in different monosolvents, and the two equations can correlate the experimental values very well. The values of root-mean-square deviations (RMSDs) and relative average deviations (RADs) between the experimental and calculated solubility values were not exceeding 0.27 × 10–6 and 0.75 × 10–2, respectively. In order to study the effect of solvation interaction on solubility, the solute–solvent and solvent–solvent interactions were discussed.

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