Solubility Measurement and Phase Equilibrium Modeling of 2-Aminobenzamide in 15 Pure Solvents
- Kui Wu*Kui Wu*E-mail: [email protected] (K.W.).School of Chemistry, Sun Yat-sen University, Guangzhou 510275, ChinaMore by Kui Wu
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- Yajun Li*Yajun Li*E-mail: [email protected] (Y.L.).Guangdong Provincial Bioengineering Institute (Guangzhou Sugarcane Industry Research Institute), Guangdong Academy of Sciences, Guangzhou 510316, ChinaMore by Yajun Li
Abstract
The solubility of 2-aminobenzamide in 15 pure organic solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, n-hexanol, n-octanol, acetone, ethyl acetate, acetonitrile, tetrahydrofuran, and methyl acetate, was measured using a gravimetric method over the temperature range from 273.15 to 324.15 K under atmosphere pressure. Four thermodynamic models, that is, Apelblat equation, λh equation, nonrandom two-liquid equation, and Wilson equation, were applied to correlate the measured solubility data. The correlation results were evaluated by the relative average deviation. The results indicated that the mole fraction solubility increased with the rising of temperature in all 15 solvents, and the Wilson model gave the best fitting results. The experimental data and correlation models would be useful in the purification and synthesis process of 2-aminobenzamide.
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