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Integrated Reaction Path Processing from Sampled Structure Sequences
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    Integrated Reaction Path Processing from Sampled Structure Sequences
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    • Michael A. Heuer
      Michael A. Heuer
      ETH Zürich, Laboratorium für Physikalische Chemie, Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland
    • Alain C. Vaucher
      Alain C. Vaucher
      ETH Zürich, Laboratorium für Physikalische Chemie, Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland
    • Moritz P. Haag
      Moritz P. Haag
      ETH Zürich, Laboratorium für Physikalische Chemie, Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland
    • Markus Reiher*
      Markus Reiher
      ETH Zürich, Laboratorium für Physikalische Chemie, Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland
      *E-mail: [email protected]
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    Journal of Chemical Theory and Computation

    Cite this: J. Chem. Theory Comput. 2018, 14, 4, 2052–2062
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    https://doi.org/10.1021/acs.jctc.8b00019
    Published March 8, 2018
    Copyright © 2018 American Chemical Society

    Abstract

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    Sampled structure sequences obtained, for instance, from real-time reactivity explorations or first-principles molecular dynamics simulations contain valuable information about chemical reactivity. Eventually, such sequences allow for the construction of reaction networks that are required for the kinetic analysis of chemical systems. For this purpose, however, the sampled information must be processed to obtain stable chemical structures and associated transition states. The manual extraction of valuable information from such reaction paths is straightforward but unfeasible for large and complex reaction networks. For real-time quantum chemistry, this implies automatization of the extraction and relaxation process while maintaining immersion in the virtual chemical environment. Here, we describe an efficient path processing scheme for the on-the-fly construction of an exploration network by approximating the explored paths as continuous basis-spline curves.

    Copyright © 2018 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jctc.8b00019.

    • The complete exploration data containing all Cartesian coordinates (XYZ)

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    Cited By

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    This article is cited by 11 publications.

    1. Jan P. Unsleber, Stephanie A. Grimmel, Markus Reiher. Chemoton 2.0: Autonomous Exploration of Chemical Reaction Networks. Journal of Chemical Theory and Computation 2022, 18 (9) , 5393-5409. https://doi.org/10.1021/acs.jctc.2c00193
    2. Pavlo O. Dral, Xin Wu, Walter Thiel. Semiempirical Quantum-Chemical Methods with Orthogonalization and Dispersion Corrections. Journal of Chemical Theory and Computation 2019, 15 (3) , 1743-1760. https://doi.org/10.1021/acs.jctc.8b01265
    3. Gregor N. Simm, Alain C. Vaucher, Markus Reiher. Exploration of Reaction Pathways and Chemical Transformation Networks. The Journal of Physical Chemistry A 2019, 123 (2) , 385-399. https://doi.org/10.1021/acs.jpca.8b10007
    4. Tamara Husch, Markus Reiher. Comprehensive Analysis of the Neglect of Diatomic Differential Overlap Approximation. Journal of Chemical Theory and Computation 2018, 14 (10) , 5169-5179. https://doi.org/10.1021/acs.jctc.8b00601
    5. Alain C. Vaucher, Markus Reiher. Minimum Energy Paths and Transition States by Curve Optimization. Journal of Chemical Theory and Computation 2018, 14 (6) , 3091-3099. https://doi.org/10.1021/acs.jctc.8b00169
    6. Katja-Sophia Csizi, Miguel Steiner, Markus Reiher. Nanoscale chemical reaction exploration with a quantum magnifying glass. Nature Communications 2024, 15 (1) https://doi.org/10.1038/s41467-024-49594-2
    7. William Z. Van Benschoten, Laura Weiler, Gabriel J. Smith, Songhang Man, Taylor DeMello, James J. Shepherd. Electronic specific heat capacities and entropies from density matrix quantum Monte Carlo using Gaussian process regression to find gradients of noisy data. The Journal of Chemical Physics 2023, 158 (21) https://doi.org/10.1063/5.0150702
    8. Shusen Chen, Taylor Nielson, Elayna Zalit, Bastian Bjerkem Skjelstad, Braden Borough, William J. Hirschi, Spencer Yu, David Balcells, Daniel H. Ess. Automated Construction and Optimization Combined with Machine Learning to Generate Pt(II) Methane C–H Activation Transition States. Topics in Catalysis 2022, 65 (1-4) , 312-324. https://doi.org/10.1007/s11244-021-01506-0
    9. Miguel Steiner, Markus Reiher. Autonomous Reaction Network Exploration in Homogeneous and Heterogeneous Catalysis. Topics in Catalysis 2022, 65 (1-4) , 6-39. https://doi.org/10.1007/s11244-021-01543-9
    10. Riley Jackson, Wenyuan Zhang, Jason Pearson. TSNet: predicting transition state structures with tensor field networks and transfer learning. Chemical Science 2021, 12 (29) , 10022-10040. https://doi.org/10.1039/D1SC01206A
    11. Tamara Husch, Alain C. Vaucher, Markus Reiher. Semiempirical molecular orbital models based on the neglect of diatomic differential overlap approximation. International Journal of Quantum Chemistry 2018, 118 (24) https://doi.org/10.1002/qua.25799

    Journal of Chemical Theory and Computation

    Cite this: J. Chem. Theory Comput. 2018, 14, 4, 2052–2062
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jctc.8b00019
    Published March 8, 2018
    Copyright © 2018 American Chemical Society

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