Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

Click to copy article linkArticle link copied!

This article is cited by 66 publications.

1. Jianzhong Chen, Jian Wang, Wanchun Yang, Lu Zhao, Jing Su. Activity Regulation and Conformation Response of Janus Kinase 3 Mediated by Phosphorylation: Exploration from Correlation Network Analysis and Markov Model. Journal of Chemical Information and Modeling 2025, 65 (8) , 4189-4205. https://doi.org/10.1021/acs.jcim.5c00096
2. Laura Scalvini, Daniele Pala, Alberto Cuzzolin, Francesca Galvani, Alessio Lodola, Silvia Rivara, Marco Mor, Andrea Rizzi. JAK3 Inhibitors: Covalent and Noncovalent Interactions of a Cyanamide Group Investigated by Multiscale Free-Energy Simulations. Journal of Chemical Information and Modeling 2025, 65 (3) , 1404-1418. https://doi.org/10.1021/acs.jcim.4c01889
3. Laura Hillebrand, Xiaojun Julia Liang, Ricardo A. M. Serafim, Matthias Gehringer. Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update. Journal of Medicinal Chemistry 2024, 67 (10) , 7668-7758. https://doi.org/10.1021/acs.jmedchem.3c01825
4. Nils Pemberton, Nina Compagne, Argyrides Argyrou, Emma Evertsson, Anders Gunnarsson, Jason G. Kettle, Jonathan P. Orme, Richard A. Ward. Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS Medicinal Chemistry Letters 2024, 15 (5) , 583-589. https://doi.org/10.1021/acsmedchemlett.3c00425
5. Mengxiao Yu, Xiaobin Liu, Xiaoyu Zhang, Jinli Zhang, You Han. Comparative Technical, Economic, and Environmental Analysis of Different Cyanamide Production Processes Optimized through Heat Integration Design. ACS Sustainable Chemistry & Engineering 2023, 11 (49) , 17371-17383. https://doi.org/10.1021/acssuschemeng.3c05120
6. Aniket Mishra, Xuefeng Cong, Masayoshi Nishiura, Zhaomin Hou. Enantioselective Synthesis of 1-Aminoindanes via [3 + 2] Annulation of Aldimines with Alkenes by Scandium-Catalyzed C–H Activation. Journal of the American Chemical Society 2023, 145 (31) , 17468-17477. https://doi.org/10.1021/jacs.3c06482
7. Ingo V. Hartung, Joachim Rudolph, Mary M. Mader, Monique P. C. Mulder, Paul Workman. Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes. Journal of Medicinal Chemistry 2023, 66 (14) , 9297-9312. https://doi.org/10.1021/acs.jmedchem.3c00550
8. Khuchtumur Bum-Erdene, I-Ju Yeh, Giovanni Gonzalez-Gutierrez, Mona K. Ghozayel, Karen Pollok, Samy O. Meroueh. Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. Journal of Medicinal Chemistry 2023, 66 (1) , 266-284. https://doi.org/10.1021/acs.jmedchem.2c01189
9. Sean P. Henry, Maria-Elena Liosi, Joseph A. Ippolito, Fabian Menges, Ana S. Newton, Joseph Schlessinger, William L. Jorgensen. Covalent Modification of the JH2 Domain of Janus Kinase 2. ACS Medicinal Chemistry Letters 2022, 13 (11) , 1819-1826. https://doi.org/10.1021/acsmedchemlett.2c00414
10. Wen-Yan Xu, Yu-Jie Li, Tian-Jun Gong, Yao Fu. Synthesis of gem-Difluorinated 1,3-Dienes via Synergistic Cu/Pd-Catalyzed Borodifluorovinylation of Alkynes. Organic Letters 2022, 24 (32) , 5884-5889. https://doi.org/10.1021/acs.orglett.2c01875
11. Shan Li, Hongfei Si, Xiaojuan Song, Chong Lei, Xiaoqiang He, Jie Wang, Yiling Liu, Yang Zhou, Jian-Guo Song, Lijie Peng, Xia Tang, Shingpan Chan, Xiaomei Ren, Zhengchao Tu, Zhengqiu Li, Zhen Wang, Zhang Zhang, Ke Ding. Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant. Journal of Medicinal Chemistry 2022, 65 (15) , 10674-10690. https://doi.org/10.1021/acs.jmedchem.2c00922
12. Romain Hany, Jean-Philippe Leyris, Guillaume Bret, Sylvie Mallié, Chamroeun Sar, Maxime Thouaye, Abdallah Hamze, Olivier Provot, Pierre Sokoloff, Jean Valmier, Pascal Villa, Didier Rognan. High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators. ACS Chemical Biology 2022, 17 (3) , 709-722. https://doi.org/10.1021/acschembio.2c00048
13. Qichao Bao, Liangying Zhang, Nan Wang, Brian Gabet, Weikang Yang, Xingyang Gao, Qidong You, Zhengyu Jiang. Hydrogen Peroxide Inducible JAK3 Covalent Inhibitor: Prodrug for the Treatment of RA with Enhanced Safety Profile. ACS Medicinal Chemistry Letters 2020, 11 (11) , 2182-2189. https://doi.org/10.1021/acsmedchemlett.0c00323
14. Edouard Duchamp, Stephen Hanessian. Cyanide-Free Synthesis of Air Stable N-Substituted Li and K Cyanamide Salts from Tetrazoles. Applications toward the Synthesis of Primary and Secondary Cyanamides as Precursors to Amidines. Organic Letters 2020, 22 (21) , 8487-8491. https://doi.org/10.1021/acs.orglett.0c03085
15. Xuefeng Cong, Gu Zhan, Zhenbo Mo, Masayoshi Nishiura, Zhaomin Hou. Diastereodivergent [3 + 2] Annulation of Aromatic Aldimines with Alkenes via C–H Activation by Half-Sandwich Rare-Earth Catalysts. Journal of the American Chemical Society 2020, 142 (12) , 5531-5537. https://doi.org/10.1021/jacs.0c01171
16. Minjian Yang, Bingzhong Tao, Chengjuan Chen, Wenqiang Jia, Shaolei Sun, Tiantai Zhang, Xiaojian Wang. Machine Learning Models Based on Molecular Fingerprints and an Extreme Gradient Boosting Method Lead to the Discovery of JAK2 Inhibitors. Journal of Chemical Information and Modeling 2019, 59 (12) , 5002-5012. https://doi.org/10.1021/acs.jcim.9b00798
17. Gaochan Wu, Tong Zhao, Dongwei Kang, Jian Zhang, Yuning Song, Vigneshwaran Namasivayam, Jacob Kongsted, Christophe Pannecouque, Erik De Clercq, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan. Overview of Recent Strategic Advances in Medicinal Chemistry. Journal of Medicinal Chemistry 2019, 62 (21) , 9375-9414. https://doi.org/10.1021/acs.jmedchem.9b00359
18. Matthias Gehringer, Stefan A. Laufer. Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology. Journal of Medicinal Chemistry 2019, 62 (12) , 5673-5724. https://doi.org/10.1021/acs.jmedchem.8b01153
19. Steven H. Spergel, Michael E. Mertzman, James Kempson, Junqing Guo, Sylwia Stachura, Lauren Haque, Jonathan S. Lippy, Rosemary F. Zhang, Michael Galella, Sidney Pitt, Guoxiang Shen, Aberra Fura, Kathleen Gillooly, Kim W. McIntyre, Vicky Tang, John Tokarski, John S. Sack, Javed Khan, Percy H. Carter, Joel C. Barrish, Steven G. Nadler, Luisa M. Salter-Cid, Gary L. Schieven, Stephen T. Wrobleski, William J. Pitts. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Medicinal Chemistry Letters 2019, 10 (3) , 306-311. https://doi.org/10.1021/acsmedchemlett.8b00508
20. Narendra Kumar, Daniel Segovia, Priyam Kumar, Hima Bindu Atti, Soaham Kumar, Jayshree Mishra. Mucosal implications of oral Jak3-targeted drugs in COVID patients. Molecular Medicine 2025, 31 (1) https://doi.org/10.1186/s10020-025-01260-z
21. Florian Fischer, Veronika Temml, Daniela Schuster. Pharmacophore Modeling of Janus Kinase Inhibitors: Tools for Drug Discovery and Exposition Prediction. Molecules 2025, 30 (10) , 2183. https://doi.org/10.3390/molecules30102183
22. Genhong Qiu, Li Yu, Lei Jia, Yanfei Cai, Yun Chen, Jian Jin, Lei Xu, Jingyu Zhu. Identification of novel covalent JAK3 inhibitors through consensus scoring virtual screening: integration of common feature pharmacophore and covalent docking. Molecular Diversity 2025, 29 (2) , 1353-1373. https://doi.org/10.1007/s11030-024-10918-5
23. Zheng Zhao, Philip E. Bourne. Advances in reversible covalent kinase inhibitors. Medicinal Research Reviews 2025, 45 (2) , 629-653. https://doi.org/10.1002/med.22084
24. Kristen A. Marino, Robert Nicewonger, Hongjun Zhang, Atli Thorarensen. Recent highlights in covalent inhibitor design. 2025https://doi.org/10.1016/B978-0-443-29808-0.00010-8
25. Neslihan Demirel Öğüt. Structures of JAK Inhibitors. 2025, 5-12. https://doi.org/10.1007/978-3-031-84274-0_2
26. Abdelmoujoud Faris, Ivana Cacciatore, Ibrahim M. Ibrahim, Mohammed H. AL Mughram, Hanine Hadni, Kamal Tabti, Menana Elhallaoui. In silico computational drug discovery: a Monte Carlo approach for developing a novel JAK3 inhibitors. Journal of Biomolecular Structure and Dynamics 2024, 42 (22) , 12548-12570. https://doi.org/10.1080/07391102.2023.2270709
27. Abdelmoujoud Faris, Ibrahim M. Ibrahim, Hanine Hadni, Menana Elhallaoui. High-throughput virtual screening of phenylpyrimidine derivatives as selective JAK3 antagonists using computational methods. Journal of Biomolecular Structure and Dynamics 2024, 42 (14) , 7574-7599. https://doi.org/10.1080/07391102.2023.2240413
28. You Lv, Pengbing Mi, Jeffrey J. Babon, Guohuang Fan, Jianxun Qi, Longxing Cao, Jiajia Lang, Jin Zhang, Faming Wang, Bostjan Kobe. Small molecule drug discovery targeting the JAK-STAT pathway. Pharmacological Research 2024, 204 , 107217. https://doi.org/10.1016/j.phrs.2024.107217
29. Faizan Ahmad, Punya Sachdeva, Bhuvi Sachdeva, Gagandeep Singh, Hemant Soni, Smriti Tandon, Misbahuddin M. Rafeeq, Mohammad Zubair Alam, Hanadi M. Baeissa, Mohammad Khalid. Dioxinodehydroeckol: A Potential Neuroprotective Marine Compound Identified by In Silico Screening for the Treatment and Management of Multiple Brain Disorders. Molecular Biotechnology 2024, 66 (4) , 663-686. https://doi.org/10.1007/s12033-022-00629-3
30. Abdelmoujoud Faris, Ivana Cacciatore, Radwan Alnajjar, Hadni Hanine, Adnane Aouidate, Ramzi A. Mothana, Abdullah R. Alanzi, Menana Elhallaoui. Revealing innovative JAK1 and JAK3 inhibitors: a comprehensive study utilizing QSAR, 3D-Pharmacophore screening, molecular docking, molecular dynamics, and MM/GBSA analyses. Frontiers in Molecular Biosciences 2024, 11 https://doi.org/10.3389/fmolb.2024.1348277
31. Tian‐Hua Wei, Meng‐Yi Lu, Si‐Hui Yao, Yu‐Qi Hong, Jin Yang, Meng‐Yuan Zhang, Yu‐Qi Yin, Yu‐Jie Han, Qing‐Qing Li, Zi‐Xuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong, Yun Zhou, Wei‐Chen Dai, Yan‐Cheng Yu, Shan‐Liang Sun, Ye Yang, Nian‐Guang Li, Zhi‐Hao Shi. Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics. MedComm – Oncology 2024, 3 (1) https://doi.org/10.1002/mog2.69
32. Rameshwar S. Cheke, Prashant S. Kharkar. Covalent inhibitors: An ambitious approach for the discovery of newer oncotherapeutics. Drug Development Research 2024, 85 (1) https://doi.org/10.1002/ddr.22132
33. S. V. Ryabukhin, D. V. Bondarenko, S. A. Trofymchuk, D. A. Lega, D. M. Volochnyuk. Aza‐Heterocyclic Building Blocks with In‐Ring CF 2 ‐Fragment. The Chemical Record 2024, 24 (2) https://doi.org/10.1002/tcr.202300283
34. Namrashee V. Mehta, Mariam S. Degani. The expanding repertoire of covalent warheads for drug discovery. Drug Discovery Today 2023, 28 (12) , 103799. https://doi.org/10.1016/j.drudis.2023.103799
35. Yongpeng Zheng, Jianxiao Li, Chaorong Qi, Wanqing Wu, Huanfeng Jiang. Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea. RSC Advances 2023, 13 (47) , 33047-33052. https://doi.org/10.1039/D3RA06051A
36. Poowadon Fukasem, M. Paul Gleeson. Design and Molecular Dynamics Simulation of Thieno-pyrimidine derivative JAK3 Inhibitor. 2023, 1-5. https://doi.org/10.1109/BMEiCON60347.2023.10322062
37. Wen‐Yan Xu, Zhe‐Yuan Xu, Ze‐Kuan Zhang, Tian‐Jun Gong, Yao Fu. Tunable Synthesis of Monofluoroalkenes and Gem‐ Difluoroalkenes via Solvent‐Controlled Rhodium‐Catalyzed Arylation of 1‐Bromo‐2,2‐difluoroethylene. Angewandte Chemie 2023, 135 (40) https://doi.org/10.1002/ange.202310125
38. Wen‐Yan Xu, Zhe‐Yuan Xu, Ze‐Kuan Zhang, Tian‐Jun Gong, Yao Fu. Tunable Synthesis of Monofluoroalkenes and Gem‐ Difluoroalkenes via Solvent‐Controlled Rhodium‐Catalyzed Arylation of 1‐Bromo‐2,2‐difluoroethylene. Angewandte Chemie International Edition 2023, 62 (40) https://doi.org/10.1002/anie.202310125
39. Morteza Abdoli, Vesa Krasniqi, Alessandro Bonardi, Michael Gütschow, Claudiu T. Supuran, Raivis Žalubovskis. 4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors. Bioorganic Chemistry 2023, 139 , 106725. https://doi.org/10.1016/j.bioorg.2023.106725
40. Jingyu Zhu, Jingyu Sun, Lei Jia, Lei Xu, Yanfei Cai, Yun Chen, Jian Jin. Machine Learning‐Enabled Virtual Screening with Multiple Protein Structures toward the Discovery of Novel JAK3 Inhibitors: Integration of Molecular Docking, Pharmacophore, and Naïve Bayesian Classification. Advanced Theory and Simulations 2023, 6 (7) https://doi.org/10.1002/adts.202200835
41. Ting Liang, Yingxiang Yang, Jiayun Wang, Zhao Xie, Xin Chen. The Application of Pyrrolo[2, 3-d]pyrimidine Scaffold in Medicinal Chemistry from 2017 to 2021. Mini-Reviews in Medicinal Chemistry 2023, 23 (10) , 1118-1136. https://doi.org/10.2174/1389557523666230111161810
42. Marlene Uglebjerg Fruergaard, Christine Juul Fælled Nielsen, Cecilia Rosada Kjeldsen, Lars Iversen, Jacob Lauwring Andersen, Poul Nissen. Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases. Life Science Alliance 2023, 6 (5) , e202201425. https://doi.org/10.26508/lsa.202201425
43. Nem Kumar Jain, Mukul Tailang, Hemant Kumar Jain, Balakumar Chandrasekaran, Biswa Mohan Sahoo, Anandhalakshmi Subramanian, Neelaveni Thangavel, Afaf Aldahish, Kumarappan Chidambaram, M. Alagusundaram, Santosh Kumar, Palani Selvam. Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review. Frontiers in Pharmacology 2023, 14 https://doi.org/10.3389/fphar.2023.1135145
44. Vinícius Bonatto, Rafael F. Lameiro, Fernanda R. Rocho, Jerônimo Lameira, Andrei Leitão, Carlos A. Montanari. Nitriles: an attractive approach to the development of covalent inhibitors. RSC Medicinal Chemistry 2023, 14 (2) , 201-217. https://doi.org/10.1039/D2MD00204C
45. Xiaochen Wang, Zeyao Ji, Jian Liu, Bingfu Wang, Hui Jin, Lixin Zhang. Advances in Organocatalytic Asymmetric Reactions Involving Thioesters. Acta Chimica Sinica 2023, 81 (1) , 64. https://doi.org/10.6023/A22100422
46. Lin Yang, Kaiyue Zhang, Meng Xu, Youyu Xie, Xiangqi Meng, Hualei Wang, Dongzhi Wei. Mechanism‐Guided Computational Design of ω‐Transaminase by Reprograming of High‐Energy‐Barrier Steps. Angewandte Chemie 2022, 134 (52) https://doi.org/10.1002/ange.202212555
47. Lin Yang, Kaiyue Zhang, Meng Xu, Youyu Xie, Xiangqi Meng, Hualei Wang, Dongzhi Wei. Mechanism‐Guided Computational Design of ω‐Transaminase by Reprograming of High‐Energy‐Barrier Steps. Angewandte Chemie International Edition 2022, 61 (52) https://doi.org/10.1002/anie.202212555
48. Kirsten McAulay, Alan Bilsland, Marta Bon. Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery. Pharmaceuticals 2022, 15 (11) , 1366. https://doi.org/10.3390/ph15111366
49. Ebrahim Saeedian Moghadam, Katayoon Mireskandari, Raid Abdel-Jalil, Mohsen Amini. An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint. Mini-Reviews in Medicinal Chemistry 2022, 22 (19) , 2486-2561. https://doi.org/10.2174/1389557522666220325150531
50. Wenhong Su, Zhiwen Chen, Meiying Liu, Rui He, Chaoyi Liu, Rui Li, Mingshan Gao, Mingyue Zheng, Zhengchao Tu, Zhang Zhang, Tianfeng Xu. Design, synthesis and structure-activity relationship studies of pyrido[2,3-d]pyrimidin-7-ones as potent Janus Kinase 3 (JAK3) covalent inhibitors. Bioorganic & Medicinal Chemistry Letters 2022, 64 , 128680. https://doi.org/10.1016/j.bmcl.2022.128680
51. Yihao Li, Dan Meng, Jiali Xie, Ruoyu Li, Zifan Wang, Jinlong Li, Lin Mou, Xinhao Deng, Ping Deng. Design of Rational JAK3 Inhibitors Based on the Parent Core Structure of 1,7-Dihydro-Dipyrrolo [2,3-b:3′,2′-e] Pyridine. International Journal of Molecular Sciences 2022, 23 (10) , 5437. https://doi.org/10.3390/ijms23105437
52. Ahmed M. Shawky, Faisal A. Almalki, Ashraf N. Abdalla, Ahmed H. Abdelazeem, Ahmed M. Gouda. A Comprehensive Overview of Globally Approved JAK Inhibitors. Pharmaceutics 2022, 14 (5) , 1001. https://doi.org/10.3390/pharmaceutics14051001
53. Yusuke Oyamada, Kazuto Inaba, Takahiro Sasamori, Shuichi Nakamura. Enantioselective reaction of N -cyano imines: decarboxylative Mannich-type reaction with malonic acid half thioesters. Chemical Communications 2022, 58 (13) , 2172-2175. https://doi.org/10.1039/D1CC07191B
54. Hui Qiu, Zahid Ali, Julian Bowlan, Richard Caldwell, Anna Gardberg, Nina Glaser, Andreas Goutopoulos, Jared Head, Theresa Johnson, Christine Maurer, Katrin Georgi, Roland Grenningloh, Zhizhou Fang, Federica Morandi, Felix Rohdich, Ralf. Schmidt, Ariele Viacava Follis, Brian Sherer. Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity. ChemMedChem 2021, 16 (24) , 3653-3662. https://doi.org/10.1002/cmdc.202100453
55. Zhen Zhang, Yongjin Wang, Xiaojuan Chen, Xiaojuan Song, Zhengchao Tu, Yongheng Chen, Zhimin Zhang, Ke Ding. Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorganic & Medicinal Chemistry 2021, 50 , 116457. https://doi.org/10.1016/j.bmc.2021.116457
56. Ivy Guan, Kayla Williams, Jolyn Pan, Xuyu Liu. New Cysteine Covalent Modification Strategies Enable Advancement of Proteome‐wide Selectivity of Kinase Modulators. Asian Journal of Organic Chemistry 2021, 10 (5) , 949-963. https://doi.org/10.1002/ajoc.202100036
57. Visekhonuo Kuotsu, Vevosa Nakro, Imkong Yanger, Tsenbeni N. Lotha, Ketiyala Tzudir, Upasana Bora Sinha, Latonglila Jamir. An environmentally benign synthesis of Tetrabutylphosphonium tribromide (TBPTB) – a versatile and efficient phase transfer reagent for organic transformations. Green Chemistry Letters and Reviews 2021, 14 (2) , 425-434. https://doi.org/10.1080/17518253.2021.1929511
58. Atli Thorarensen, Paul Balbo, Mary E. Banker, Robert M. Czerwinski, Max Kuhn, Tristan S. Maurer, Jean-Baptiste Telliez, Fabien Vincent, Arthur J. Wittwer. The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization. Bioorganic & Medicinal Chemistry 2021, 29 , 115865. https://doi.org/10.1016/j.bmc.2020.115865
59. Elena De Vita. 10 Years Into the Resurgence of Covalent Drugs. Future Medicinal Chemistry 2021, 13 (2) , 193-210. https://doi.org/10.4155/fmc-2020-0236
60. Shovan Mondal, Suniti Malakar. Synthesis of sulfonamide and their synthetic and therapeutic applications: Recent advances. Tetrahedron 2020, 76 (48) , 131662. https://doi.org/10.1016/j.tet.2020.131662
61. Samuel E. Dalton, Sebastien Campos. Covalent Small Molecules as Enabling Platforms for Drug Discovery. ChemBioChem 2020, 21 (8) , 1080-1100. https://doi.org/10.1002/cbic.201900674
62. Pengfei Xu, Pei Shen, Bin Yu, Xi Xu, Raoling Ge, Xinying Cheng, Qiuyu Chen, Jinlei Bian, Zhiyu Li, JuBo Wang. Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders. European Journal of Medicinal Chemistry 2020, 192 , 112155. https://doi.org/10.1016/j.ejmech.2020.112155
63. Matthias Gehringer. Covalent Kinase Inhibitors: An Overview. 2020, 43-94. https://doi.org/10.1007/7355_2020_103
64. Jun Dai, LiXi Yang, Glynn Addison. Current Status in the Discovery of Covalent Janus Kinase 3 (JAK3) Inhibitors. Mini-Reviews in Medicinal Chemistry 2019, 19 (18) , 1531-1543. https://doi.org/10.2174/1389557519666190617152011
65. Henry van den Bedem, Mark A Wilson. Shining light on cysteine modification: connecting protein conformational dynamics to catalysis and regulation. Journal of Synchrotron Radiation 2019, 26 (4) , 958-966. https://doi.org/10.1107/S160057751900568X
66. Warren J. Leonard, Jian-Xin Lin, John J. O'Shea. The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications. Immunity 2019, 50 (4) , 832-850. https://doi.org/10.1016/j.immuni.2019.03.028