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Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescensClick to copy article linkArticle link copied!
- Luke P. RobertsonLuke P. RobertsonEnvironmental Futures Research Institute, Griffith University, Gold Coast Campus, Southport 4222, AustraliaGriffith Institute for Drug Discovery, Griffith University, Nathan Campus, Brisbane 4111, AustraliaMore by Luke P. Robertson
- Leonardo LucantoniLeonardo LucantoniGriffith Institute for Drug Discovery, Griffith University, Nathan Campus, Brisbane 4111, AustraliaMore by Leonardo Lucantoni
- Sandra DuffySandra DuffyGriffith Institute for Drug Discovery, Griffith University, Nathan Campus, Brisbane 4111, AustraliaMore by Sandra Duffy
- Vicky M. AveryVicky M. AveryGriffith Institute for Drug Discovery, Griffith University, Nathan Campus, Brisbane 4111, AustraliaMore by Vicky M. Avery
- Anthony R. Carroll*Anthony R. Carroll*Tel.: +61 7 55529187. Fax: +61 7 55529047. E-mail: [email protected]Environmental Futures Research Institute, Griffith University, Gold Coast Campus, Southport 4222, AustraliaGriffith Institute for Drug Discovery, Griffith University, Nathan Campus, Brisbane 4111, AustraliaMore by Anthony R. Carroll
Abstract
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A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3-c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC50 values ranging from 1.7 to 4.7 μM.
Copyright © 2019 American Chemical Society and American Society of Pharmacognosy
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