Taichunins A–D, Norditerpenes from Aspergillus taichungensis (IBT 19404)Click to copy article linkArticle link copied!
- Hikaru KatoHikaru KatoGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, JapanMore by Hikaru Kato
- Momona SebeMomona SebeGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, JapanMore by Momona Sebe
- Mika NagakiMika NagakiGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, JapanMore by Mika Nagaki
- Keisuke EguchiKeisuke EguchiGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, JapanMore by Keisuke Eguchi
- Ippei KagiyamaIppei KagiyamaGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, JapanMore by Ippei Kagiyama
- Yuki HitoraYuki HitoraGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, JapanMore by Yuki Hitora
- Jens C. FrisvadJens C. FrisvadSection for Eukaryotic Biotechnology, Departments of System Biology, Technical University of Denmark, Building 221, 2800 Kongens Lyngby, DenmarkMore by Jens C. Frisvad
- Robert M. WilliamsRobert M. WilliamsDepartment of Chemistry, Colorado State University, 301 West Pitkin Street, Fort Collins, Colorado 80523, United StatesUniversity of Colorado Cancer Center, Aurora, Colorado 80045, United StatesMore by Robert M. Williams
- Sachiko Tsukamoto*Sachiko Tsukamoto*E-mail: [email protected]Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, JapanMore by Sachiko Tsukamoto
Abstract
Four new norditerpenes, taichunins A–D (1–4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2–4 were nontoxic at 50 μM.
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This article is cited by 8 publications.
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