Mallopenins A–E, Antibacterial Phenolic Derivatives from the Fruits of Mallotus philippensisClick to copy article linkArticle link copied!
- Sarot Cheenpracha*Sarot Cheenpracha*Tel (S. Cheenpracha): +66-5446-6666. Fax: +66-5446-6664. E-mail: [email protected]Division of Chemistry, School of Science, University of Phayao, Phayao 56000, ThailandMore by Sarot Cheenpracha
- Stephen G. PyneStephen G. PyneSchool of Chemistry and Molecular Biosciences, University of Wollongong, Wollongong, New South Wales 2522, AustraliaMore by Stephen G. Pyne
- Brian O. PatrickBrian O. PatrickDepartment of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1More by Brian O. Patrick
- Raymond J. AndersenRaymond J. AndersenDepartment of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1More by Raymond J. Andersen
- Wisanu ManeeratWisanu ManeeratCenter of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandMore by Wisanu Maneerat
- Surat LaphookhieoSurat LaphookhieoCenter of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandMore by Surat Laphookhieo
Abstract
The chromatographic separation of the components of the acetone extract of Mallotus philippensis fruits yielded five new phenolic compounds including two chalcones, 1 and 3, a functionalized phloroglucinol, 2, two flavanones, 4 and 5, and six known compounds. The structures of 1–5 were confirmed by NMR and mass analyses. Racemic compounds 1 and 2 were separated by chiral-phase HPLC, and the absolute configuration of (+)-1 was confirmed by X-ray diffraction studies and ECD spectroscopic data. The configurations of the enantiomers of 2 were defined by comparison of its ECD data with those of (+)-1. Compounds 6 and 7 exhibited significant antibacterial activities, with MIC values ranging from 3.8 to 15.5 μM.
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