Analysis of Stereochemical Stability of Dynamic Chiral Molecules Using an Automated Microflow Measurement System
- Kazunobu Igawa*Kazunobu Igawa*Email: [email protected]Institute for Materials Chemistry and Engineering, IRCCS and Department of Molecular and Material Sciences, Kyushu University, Kasuga, Fukuoka 816-8580, JapanMore by Kazunobu Igawa
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- Shusaku Asano*Shusaku Asano*Email: [email protected]Institute for Materials Chemistry and Engineering, IRCCS, Kyushu University, Kasuga, Fukuoka 816-8580, JapanMore by Shusaku Asano
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- Yuki YoshidaYuki YoshidaDepartment of Molecular and Material Sciences, Kyushu University, Kasuga, Fukuoka 816-8580, JapanMore by Yuki Yoshida
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- Yuuya KawasakiYuuya KawasakiInstitute for Materials Chemistry and Engineering, IRCCS, Kyushu University, Kasuga, Fukuoka 816-8580, JapanMore by Yuuya Kawasaki
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- Katsuhiko Tomooka*Katsuhiko Tomooka*Email: [email protected]Institute for Materials Chemistry and Engineering, IRCCS and Department of Molecular and Material Sciences, Kyushu University, Kasuga, Fukuoka 816-8580, JapanMore by Katsuhiko Tomooka
Abstract
An automated microflow measurement system for the kinetic study of racemization of dynamic chiral molecules was developed. This system facilitated the analysis of fast racemization within several seconds at elevated temperatures owing to its rapid heating ability, high performance for controlling short residence times, and ease of connection to HPLC systems for direct measurement of the enantiomeric purity. A more precise analysis was realized by combination of microflow and common batch measurements over a broad range of temperatures.
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