Early Stages of RNA-Mediated Conversion of Human PrionsClick to copy article linkArticle link copied!
- Emilia A. Lubecka*Emilia A. Lubecka*Email: [email protected]Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, G. Narutowicza 11/12, 80-233 Gdansk, PolandMore by Emilia A. Lubecka
- Ulrich H. E. Hansmann*Ulrich H. E. Hansmann*Email: [email protected]Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019,United StatesMore by Ulrich H. E. Hansmann
Abstract
Prion diseases are characterized by the conversion of prion proteins from a PrPC fold into a disease-causing PrPSC form that is self-replicating. A possible agent to trigger this conversion is polyadenosine RNA, but both mechanism and pathways of the conversion are poorly understood. Using coarse-grained molecular dynamic simulations we study the time evolution of PrPC over 600 μs. We find that both the D178N mutation and interacting with polyadenosine RNA reduce the helicity of the protein and encourage formation of segments with strand-like motifs. We conjecture that these transient β-strands nucleate the conversion of the protein to the scrapie conformation PrPSC.
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This article is cited by 1 publications.
- Jozef Nahalka. 1-L Transcription in Prion Diseases. International Journal of Molecular Sciences 2024, 25
(18)
, 9961. https://doi.org/10.3390/ijms25189961
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