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Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses

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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Proteome Res. 2015, 14, 8, 3322-3335
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    Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses
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    † CEA, LIST, Laboratory for Data Analysis and Smart Systems, MetaboHUB Paris, F-91191 Gif-sur-Yvette, France
    ‡ Laboratoire d’Etude du Métabolisme des Médicaments, DSV/iBiTec-S/SPI, MetaboHUB Paris, CEA-Saclay, Gif-Sur-Yvette, France
    *Etienne A. Thévenot: Phone: 33-1-69-08-79-23. Fax: 33-1-69-08-89-65. E-mail: [email protected]
    *Christophe Junot: Phone: 33-1-69-08-43-66. Fax: 33-1-69-08-59-07. E-mail: [email protected]
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    Journal of Proteome Research

    Cite this: J. Proteome Res. 2015, 14, 8, 3322–3335
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    https://doi.org/10.1021/acs.jproteome.5b00354
    Published June 19, 2015
    Copyright © 2015 American Chemical Society
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    Abstract

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    Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological information is however very scarce in the literature and in metabolomics databases so far. Here we studied the influence of age, body mass index (BMI), and gender on metabolite concentrations in a large cohort of 183 adults by using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). We implemented a comprehensive statistical workflow for univariate hypothesis testing and modeling by orthogonal partial least-squares (OPLS), which we made available to the metabolomics community within the online Workflow4Metabolomics.org resource. We found 108 urine metabolites displaying concentration variations with either age, BMI, or gender, by integrating the results from univariate p-values and multivariate variable importance in projection (VIP). Several metabolite clusters were further evidenced by correlation analysis, and they allowed stratification of the cohort. In conclusion, our study highlights the impact of gender and age on the urinary metabolome, and thus it indicates that these factors should be taken into account for the design of metabolomics studies.

    Copyright © 2015 American Chemical Society

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    Supporting Information

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    Text document containing the supplementary figures (Figure S1, data description; Figure S2, signal drift correction and batch effect removal; Figure S3, OPLS models with data obtained in the negative ionization mode; Figure S4, significance of R2Y and Q2Y values estimated by permutation testing; Figure S5, p-values vs VIP comparison for the data sets from the negative ionization mode; Figure S6, relationship between VIP from one predictive PLS or OPLS model with standardized variables, and p-values from the Pearson correlation test) and the theory section comparing univariate and multivariate selection in the case of single-response, single-predictive PLS models with standardized variables. Spreadsheet with the preprocessed peak tables from the positive and negative ionization modes, in addition to the sample and variable metadata. Graphics of all the significant metabolites listed in Table 1. The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jproteome.5b00354.

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    58. Cenghong Hu, Hao Li, Cuiling Tong, Dejian Zhang, Yunmei Lu. Integrated transcriptomic and metabolomic analyses reveal the effect of mycorrhizal colonization on trifoliate orange root hair. Scientia Horticulturae 2024, 336 , 113429. https://doi.org/10.1016/j.scienta.2024.113429
    59. Han Zhao, Qiao Mou, Fang Wang, Zhi-Qiang Du, Cai-Xia Yang. Profile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C. The Journal of Steroid Biochemistry and Molecular Biology 2024, 243 , 106580. https://doi.org/10.1016/j.jsbmb.2024.106580
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    67. Abzer K. Pakkir Shah, Axel Walter, Filip Ottosson, Francesco Russo, Marcelo Navarro-Diaz, Judith Boldt, Jarmo-Charles J. Kalinski, Eftychia Eva Kontou, James Elofson, Alexandros Polyzois, Carolina González-Marín, Shane Farrell, Marie R. Aggerbeck, Thapanee Pruksatrakul, Nathan Chan, Yunshu Wang, Magdalena Pöchhacker, Corinna Brungs, Beatriz Cámara, Andrés Mauricio Caraballo-Rodríguez, Andres Cumsille, Fernanda de Oliveira, Kai Dührkop, Yasin El Abiead, Christian Geibel, Lana G. Graves, Martin Hansen, Steffen Heuckeroth, Simon Knoblauch, Anastasiia Kostenko, Mirte C. M. Kuijpers, Kevin Mildau, Stilianos Papadopoulos Lambidis, Paulo Wender Portal Gomes, Tilman Schramm, Karoline Steuer-Lodd, Paolo Stincone, Sibgha Tayyab, Giovanni Andrea Vitale, Berenike C. Wagner, Shipei Xing, Marquis T. Yazzie, Simone Zuffa, Martinus de Kruijff, Christine Beemelmanns, Hannes Link, Christoph Mayer, Justin J. J. van der Hooft, Tito Damiani, Tomáš Pluskal, Pieter Dorrestein, Jan Stanstrup, Robin Schmid, Mingxun Wang, Allegra Aron, Madeleine Ernst, Daniel Petras. Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data. Nature Protocols 2024, 13 https://doi.org/10.1038/s41596-024-01046-3
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    Cite this: J. Proteome Res. 2015, 14, 8, 3322–3335
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