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Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications

  • Yuji Teramura*
    Yuji Teramura
    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan
    Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden
    *Phone: +81(0)3-5841-1174. Email: [email protected]
  • Kristina Nilsson Ekdahl
    Kristina Nilsson Ekdahl
    Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden
    Linnaeus Center of Biomaterials Chemistry, Linnaeus University, SE-391 82 Kalmar, Sweden
  • Karin Fromell
    Karin Fromell
    Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden
  • Bo Nilsson
    Bo Nilsson
    Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden
    More by Bo Nilsson
  • , and 
  • Kazuhiko Ishihara
    Kazuhiko Ishihara
    Department of Material Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan
Cite this: Langmuir 2020, 36, 41, 12088–12106
Publication Date (Web):September 14, 2020
https://doi.org/10.1021/acs.langmuir.0c01678
Copyright © 2020 American Chemical Society

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    Abstract

    Abstract Image

    The regulation of the cellular surface with biomaterials can contribute to the progress of biomedical applications. In particular, the cell surface is exposed to immunological surveillance and reactions in transplantation therapy, and modulation of cell surface properties might improve transplantation outcomes. The transplantation of therapeutic cells, tissue, and organs is an effective and fundamental treatment and has contributed to saving lives and improving quality of life. Because of shortages, donor cells, tissues, and organs are carefully transplanted with the goal of retaining activity and viability. However, some issues remain to be resolved in terms of reducing side effects, improving graft survival, managing innate and adaptive immune responses, and improving transplant storage and procedures. Given that the transplantation process involves multiple steps and is technically complicated, an engineering approach together with medical approaches to resolving these issues could enhance success. In particular, cell surface engineering with biocompatible polymers looks promising for improving transplantation therapy and has potential for other biomedical applications. Here we review the significance of polymer-based surface modification of cells and organs for biomedical applications, focusing on the following three topics: Cell protection: cellular protection through local immune regulation using cell surface modification with biocompatible polymers. This protection could extend to preventing attack by the host immune system, freeing recipients from taking immunosuppressive drugs, and avoiding a second transplantation. Cell attachment: cell manipulation, which is an important technique for delivery of therapeutic cells and their alignment for recellularization of decellularized tissues and organs in regenerative therapy. Cell fusion: fusion of different cells, which can lead to the formation of new functional cells that could be useful for generating, e.g., immunologically competent or metabolically active cells.

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    Cited By

    This article is cited by 12 publications.

    1. Shan Bai, Jingai Zhang, Yong Gao, Xiaoqi Chen, Kai Wang, Xiaoyan Yuan. Surface Functionalization of Electrospun Scaffolds by QK-AG73 Peptide for Enhanced Interaction with Vascular Endothelial Cells. Langmuir 2023, 39 (39) , 14162-14172. https://doi.org/10.1021/acs.langmuir.3c02174
    2. Yuya Sato, Kenta Asawa, Tianwei Huang, Makoto Noiri, Naoko Nakamura, Kristina N. Ekdahl, Bo Nilsson, Kazuhiko Ishihara, Yuji Teramura. Induction of Spontaneous Liposome Adsorption by Exogenous Surface Modification with Cell-Penetrating Peptide-Conjugated Lipids. Langmuir 2021, 37 (32) , 9711-9723. https://doi.org/10.1021/acs.langmuir.1c01072
    3. Qi Wang, Lishan Hu, Xiaoyu Wang, Ruikang Tang. Expanding from materials to biology inspired by biomineralization. Interdisciplinary Materials 2024, 30 https://doi.org/10.1002/idm2.12144
    4. Yihong Zhong, Lijia Xu, Chen Yang, Le Xu, Guyu Wang, Yuna Guo, Songtao Cheng, Xiao Tian, Changjiang Wang, Ran Xie, Xiaojian Wang, Lin Ding, Huangxian Ju. Site-selected in situ polymerization for living cell surface engineering. Nature Communications 2023, 14 (1) https://doi.org/10.1038/s41467-023-43161-x
    5. Navid Rabiee. Natural components as surface engineering agents for CRISPR delivery. Environmental Research 2023, 232 , 116333. https://doi.org/10.1016/j.envres.2023.116333
    6. Fengying Cai, Yafeng Ren, Jiajia Dai, Jianmin Yang, Xianai Shi. Effects of Various Cell Surface Engineering Reactions on the Biological Behavior of Mammalian Cells. Macromolecular Bioscience 2023, 23 (3) https://doi.org/10.1002/mabi.202200379
    7. Jianghai Tang, Xuanjin Chen, Hang Shi, Mingming Zhang, Zhimin Zhou, Chuangnian Zhang, Tingyu Ke, Deling Kong, Chen Li. Prebiotic inulin nanocoating for pancreatic islet surface engineering. Biomaterials Science 2023, 11 (4) , 1470-1485. https://doi.org/10.1039/D2BM01009G
    8. Yuji TERAMURA. Cell Surface Modification for Cell Manipulation and Cell Fusion. Oleoscience 2023, 23 (5) , 249-257. https://doi.org/10.5650/oleoscience.23.249
    9. Ryosuke Mizuta, Yoshihiro Sasaki, Kiyofumi Katagiri, Shin-ichi Sawada, Kazunari Akiyoshi. Reversible conjugation of biomembrane vesicles with magnetic nanoparticles using a self-assembled nanogel interface: single particle analysis using imaging flow cytometry. Nanoscale Advances 2022, 4 (8) , 1999-2010. https://doi.org/10.1039/D1NA00834J
    10. Mason Daniel Hurd, Isha Goel, Yasuyuki Sakai, Yuji Teramura. Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine. Regenerative Therapy 2021, 18 , 408-417. https://doi.org/10.1016/j.reth.2021.09.009
    11. Seoyoung Jang, Jin Gil Jeong, Tong In Oh, EunAh Lee. Biomaterials for Cell-Surface Engineering and Their Efficacy. Journal of Functional Biomaterials 2021, 12 (3) , 41. https://doi.org/10.3390/jfb12030041
    12. Yihao Cui, Benke Li, Xiaoyu Wang, Ruikang Tang. Organism–Materials Integration: A Promising Strategy for Biomedical Applications. Advanced NanoBiomed Research 2021, 1 (2) https://doi.org/10.1002/anbr.202000044

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