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Transferred Photothermal to Photodynamic Therapy Based on the Marriage of Ultrathin Titanium Carbide and Up-Conversion Nanoparticles

  • Danyang Xu
    Danyang Xu
    Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, P. R. China
    More by Danyang Xu
  • Fan Yang
    Fan Yang
    Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, P. R. China
    More by Fan Yang
  • Danyao Qu
    Danyao Qu
    Interdisciplinary Research Center of Smart Sensor, School of Advanced Materials and Nanotechnology, Xidian University, Xi’an, Shaanxi 710071, P. R. China
    More by Danyao Qu
  • Zhenni Wang
    Zhenni Wang
    Interdisciplinary Research Center of Smart Sensor, School of Advanced Materials and Nanotechnology, Xidian University, Xi’an, Shaanxi 710071, P. R. China
    More by Zhenni Wang
  • Long Gu
    Long Gu
    Interdisciplinary Research Center of Smart Sensor, School of Advanced Materials and Nanotechnology, Xidian University, Xi’an, Shaanxi 710071, P. R. China
    More by Long Gu
  • Weiwei Wu*
    Weiwei Wu
    Interdisciplinary Research Center of Smart Sensor, School of Advanced Materials and Nanotechnology, Xidian University, Xi’an, Shaanxi 710071, P. R. China
    *Email:[email protected]
    More by Weiwei Wu
  • , and 
  • Ruichan Lv*
    Ruichan Lv
    Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, P. R. China
    *Email: [email protected]
    More by Ruichan Lv
Cite this: Langmuir 2020, 36, 43, 13060–13069
Publication Date (Web):October 23, 2020
https://doi.org/10.1021/acs.langmuir.0c02521
Copyright © 2020 American Chemical Society

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    Abstract

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    In this research, upconversion nanoparticles (UCNPs) are used as a light conversion carrier, and their deep light source penetrability is closely combined with ultrathin two-dimensional (2D) Ti3C2Tx to explore the application efficiency of the complex in phototherapy. Due to the advantages of 2D Ti3C2Tx with its high absorbance to ultraviolet/visible light, rich atomic defects to load the drugs, and adjustable thinner structure, this 2D material is beneficially applied as the energy donor. UCNPs@Ti3C2Tx with a photothermal conversion efficiency of 20.7% is proven with the ability to generate reactive oxygen species under a 980 nm laser at the cellular level. Importantly, the main photothermal therapy method can be changed to a photodynamic therapy method due to the degradation of Ti3C2Tx to TiO2 under the oxygen-bearing environment. The in vivo experiment was continued to verify that UCNPs@Ti3C2Tx can kill tumor cells and inhibit tumor growth within a certain period. In addition, in vivo treatment with a combination of immunotherapy and phototherapy of UCNPs@ Ti3C2Tx is carried out to achieve stronger tumor inhibition over the prolonged time points.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.langmuir.0c02521.

    • Zeta potential of Ti3C2Tx; XRD patterns of the Ti3AlC2, Ti3C2Tx, UCNPs, UCNPs@Ti3C2Tx with the corresponding standard JCPDS attached; infrared photothermal photographs of Ti3C2Tx and water under the 980 nm laser irradiation, wherein the pump power is 0.7 W/cm2; calculation of the PCE value of Ti3C2Tx and infrared photothermal photographs of Ti3C2Tx and water under 655 nm laser irradiation, wherein the pump power is 0.7 W/cm2; calculation of PCE value of Ti3C2Tx and infrared photothermal photographs of Ti3C2Tx and water under 808 nm laser irradiation, wherein the pump power is 0.7 W/cm2; calculation of PCE value of Ti3C2Tx and infrared photothermal photographs of Ti3C2Tx and water under 1064 nm laser irradiation, wherein the pump power is 0.7 W/cm2 (PDF)

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    Cited By

    This article is cited by 6 publications.

    1. Bixiao Li, Danyang Xu, Yitong Chen, Wenjing Li, Hanyu Liu, Anees A. Ansari, Ruichan Lv. Polyethylenimine-Coated Pt–Mn Nanostructures for Synergistic Photodynamic/Photothermal/Chemodynamic Tumor Therapy. ACS Applied Nano Materials 2024, 7 (8) , 9428-9440. https://doi.org/10.1021/acsanm.4c00890
    2. Ruiyi Dai, Xiangrong Peng, Bi Lin, Danyang Xu, Ruichan Lv. NIR II Luminescence Imaging for Sentinel Lymph Node and Enhanced Chemo-/Photothermal Therapy for Breast Cancer. Bioconjugate Chemistry 2021, 32 (9) , 2117-2127. https://doi.org/10.1021/acs.bioconjchem.1c00393
    3. Suresh Sagadevan, Won-Chun Oh. Comprehensive utilization and biomedical application of MXenes - A systematic review of cytotoxicity and biocompatibility. Journal of Drug Delivery Science and Technology 2023, 85 , 104569. https://doi.org/10.1016/j.jddst.2023.104569
    4. Ruichan Lv, Micah Raab, Yanxing Wang, Jie Tian, Jun Lin, Paras N. Prasad. Nanochemistry advancing photon conversion in rare-earth nanostructures for theranostics. Coordination Chemistry Reviews 2022, 460 , 214486. https://doi.org/10.1016/j.ccr.2022.214486
    5. Anees A. Ansari, Abdul K. Parchur, Guanying Chen. Surface modified lanthanide upconversion nanoparticles for drug delivery, cellular uptake mechanism, and current challenges in NIR-driven therapies. Coordination Chemistry Reviews 2022, 457 , 214423. https://doi.org/10.1016/j.ccr.2022.214423
    6. Riya Dutta, Puspendu Barik. Upconversion and Downconversion Quantum Dots for Biomedical and Therapeutic Applications. 2022, 229-263. https://doi.org/10.1007/978-981-19-3144-4_12

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