Hydrostatic Pressure-Regulated Cellular Calcium Responses
- Minami FukuchiMinami FukuchiDepartment of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, JapanMore by Minami Fukuchi,
- Kotaro Oyama*Kotaro Oyama*Email: [email protected]Takasaki Advanced Radiation Research Institute, National Institutes for Quantum and Radiological Science and Technology (QST), 1233 Watanukimachi, Takasaki, Gunma 370-1292, JapanJST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, JapanMore by Kotaro Oyama,
- Hiroaki MizunoHiroaki MizunoDepartment of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, JapanMore by Hiroaki Mizuno,
- Akihisa MiyagawaAkihisa MiyagawaDepartment of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, JapanMore by Akihisa Miyagawa,
- Kazuya KoumotoKazuya KoumotoDepartment of Nanobiochemistry, FIRST (Frontiers of Innovative Research in Science and Technology), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, JapanMore by Kazuya Koumoto, and
- Gaku Fukuhara*Gaku Fukuhara*Email: [email protected]Department of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, JapanJST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, JapanMore by Gaku Fukuhara
Abstract
Hydrostatic pressure control has attracted much attention and presents a still challenging objective from mechanobiological viewpoints. Herein, we reveal the calcium entry processes in HeLa cells by means of hydrostatic pressure spectroscopy. The steady-state fluorescence spectral data comprehensively elucidated the factors controlling the outcomes of the hydrostatic pressure-stimulated calcium entry behavior. The present work leads to a new perspective on ion regulations in living cells and an attractive alternative to conventional mechanostimuli.