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Concentration-Dependent Viscoelasticity of Poloxamer-Shelled Microbubbles

Cite this: Langmuir 2023, 39, 1, 433–441
Publication Date (Web):December 29, 2022
https://doi.org/10.1021/acs.langmuir.2c02690
Copyright © 2022 American Chemical Society

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    Abstract

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    The oscillation of shelled microbubbles during exposure to ultrasound is influenced by the mechanical properties of the shell components. The oscillation behavior of bubbles coated with various phospholipids and other amphiphiles has been studied. However, there have been few investigations of how the adsorption conditions of the shell molecules relate to the viscoelastic properties of the shell and influence the oscillation behavior of the bubbles. In the present study, we investigated the oscillation characteristics of microbubbles coated with a poloxamer surfactant, that is, Pluronic F-68, at several concentrations after the adsorption kinetics of the surfactant at the gas–water interface had reached equilibrium. The dilatational viscoelasticity of the shell during exposure to ultrasound was analyzed in the frequency domain from the attenuation characteristics of the acoustic pulses propagated in the bubble suspension. At Pluronic F-68 concentrations lower than 2.0 × 10–2 mol L–1, the attenuation characteristics typically exhibited a sharp peak. At concentrations higher than 2.0 × 10–2 mol L–1, the peak flattened. The dilatational elasticity and viscosity of the shell were estimated by fitting the theoretical model to the experimental values, which revealed that both the elasticity and viscosity increased markedly at approximately 2.0 × 10–2 mol L–1. This suggests that the adsorption properties of Pluronic F-68 strongly affect the oscillation characteristics of microbubbles of a size suitable for medical ultrasound diagnostics.

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    Cited By

    This article is cited by 2 publications.

    1. Intesar O. Zalloum, Amin Jafari Sojahrood, Ali A. Paknahad, Michael C. Kolios, Scott S. H. Tsai, Raffi Karshafian. Controlled Tempering of Lipid Concentration and Microbubble Shrinkage as a Possible Mechanism for Fine-Tuning Microbubble Size and Shell Properties. Langmuir 2023, 39 (49) , 17622-17631. https://doi.org/10.1021/acs.langmuir.3c01599
    2. A.J. Sojahrood, Q. Li, H. Haghi, R. Karshafian, T.M. Porter, M.C. Kolios. Probing the pressure dependence of sound speed and attenuation in bubbly media: Experimental observations, a theoretical model and numerical calculations. Ultrasonics Sonochemistry 2023, 95 , 106319. https://doi.org/10.1016/j.ultsonch.2023.106319

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