Synthesis of Stable Cerium Oxide Nanoparticles Coated with Phosphonic Acid-Based Functional Polymers
- Ameni DhouibAmeni DhouibUniversité Paris Cité, CNRS, Matière et Systèmes Complexes, 75013 Paris, FranceMore by Ameni Dhouib
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- Braham MezghraniBraham MezghraniUniversité Paris Cité, CNRS, Matière et Systèmes Complexes, 75013 Paris, FranceMore by Braham Mezghrani
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- Giusy FinocchiaroGiusy FinocchiaroUniversité Paris Cité, CNRS, Matière et Systèmes Complexes, 75013 Paris, FranceInstitute of Photonics and Electronics of the Czech Academy of Sciences, Chaberská1014/57, 182 51 Prague, Czech RepublicMore by Giusy Finocchiaro
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- Rémi Le BorgneRémi Le BorgneUniversité Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, FranceMore by Rémi Le Borgne
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- Mathéo BerthetMathéo BerthetSpecific Polymers, ZAC Via Domitia, 150 Avenue des Cocardières, 34160 Castries, FranceMore by Mathéo Berthet
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- Bénédicte Daydé-CazalsBénédicte Daydé-CazalsSpecific Polymers, ZAC Via Domitia, 150 Avenue des Cocardières, 34160 Castries, FranceMore by Bénédicte Daydé-Cazals
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- Alain GraillotAlain GraillotSpecific Polymers, ZAC Via Domitia, 150 Avenue des Cocardières, 34160 Castries, FranceMore by Alain Graillot
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- Xiaohui Ju*Xiaohui Ju*Email: [email protected]Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech RepublicDepartment of Surface and Plasma Science, Faculty of Mathematics and Physics, Charles University, 181 00 Prague, Czech RepublicMore by Xiaohui Ju
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- Jean-François Berret*Jean-François Berret*Email: [email protected]Université Paris Cité, CNRS, Matière et Systèmes Complexes, 75013 Paris, FranceMore by Jean-François Berret
Abstract
Functional polymers, such as poly(ethylene glycol) (PEG), terminated with a single phosphonic acid, hereafter PEGik-Ph are often applied to coat metal oxide surfaces during post-synthesis steps but are not sufficient to stabilize sub-10 nm particles in protein-rich biofluids. The instability is attributed to the weak binding affinity of post-grafted phosphonic acid groups, resulting in a gradual detachment of the polymers from the surface. Here, we assess these polymers as coating agents using an alternative route, namely, the one-step wet-chemical synthesis, where PEGik-Ph is introduced with cerium precursors during the synthesis. Characterization of the coated cerium oxide nanoparticles (CNPs) indicates a core–shell structure, where the cores are 3 nm cerium oxide and the shell consists of functionalized PEG polymers in a brush configuration. Results show that CNPs coated with PEG1k-Ph and PEG2k-Ph are of potential interest for applications as nanomedicines due to their high Ce(III) content and increased colloidal stability in cell culture media. We further demonstrate that the CNPs in the presence of hydrogen peroxide show an additional absorbance band in the UV–vis spectrum, which is attributed to Ce–O22– peroxo-complexes and could be used in the evaluation of their catalytic activity for scavenging reactive oxygen species.
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