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Effect of Local Chain Dynamics on a Bioinert Interface

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† § Department of Applied Chemistry, Education Center for Global Leaders in Molecular Systems for Devices, and §International Institute for Carbon-Neutral Energy Research (WPI-I2CNER), Kyushu University, Fukuoka 819-0395, Japan
Neutron Science Laboratory, High Energy Accelerator Research Organization, Ibaraki 305-0801, Japan
Department of Biochemical Engineering, Yamagata University, Yamagata 992-8510, Japan
*E-mail: [email protected]. Fax: +81-92-802-2880. Tel: +81-92-802-2879.
*E-mail: [email protected]. Fax: +81-92-802-2880. Tel: +81-92-802-2878.
Cite this: Langmuir 2015, 31, 12, 3661–3667
Publication Date (Web):March 11, 2015
https://doi.org/10.1021/acs.langmuir.5b00258
Copyright © 2015 American Chemical Society

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    Abstract

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    Although many kinds of synthetic polymers have been investigated to construct blood-compatible materials, only a few have achieved success. To establish molecular designs for blood-compatible polymers, the chain structure and dynamics at the water interface must be understood using solid evidence as the first bench mark. Here we show that polymer dynamics at the water interface impacts on structure of the interfacial water, resulting in a change in protein adsorption and of platelet adhesion. As a particular material, a blend composed of poly(2-methoxyethyl acrylate) (PMEA) and poly(methyl methacrylate) was used. PMEA was segregated to the water interface. While the local conformation of PMEA at the water interface was insensitive to its molecular weight, the local dynamics became faster with decreasing molecular weight, resulting in a disturbance of the network structure of waters at the interface. This leads to the extreme suppression of protein adsorption and platelet adhesion.

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    Experimental procedures for polymer synthesis, film preparation, and NR measurements and additional data for NR analyses. This material is available free of charge via the Internet at http://pubs.acs.org.

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