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Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity
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    Supramolecular Conjugated Polymer Systems with Controlled Antibacterial Activity
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    Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, United States
    *E-mail: [email protected] (L.L.).
    *E-mail: [email protected] (S.W.).
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    Langmuir

    Cite this: Langmuir 2017, 33, 4, 1116–1120
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    https://doi.org/10.1021/acs.langmuir.6b04469
    Published January 6, 2017
    Copyright © 2017 American Chemical Society

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    Infections of antibiotic-resistant pathogens have caused a series of public health crises across the world. According to the latest published reports, an antibiotic switch has been recognized as a potential strategy to control antibacterial activity for combating this serious drug resistance. Thus, it is anticipated that more effective antibiotic switches should be obtained by further exploring the developed strategies. Here, we report an improved pretreatment strategy using a surfactant (Triton X-100) for constructing an effective supramolecular antibiotic switch based on a poly(fluorene-co-phenylene) derivative (PFP) and cucurbit[7]uril (CB[7]), which can regulate the aggregation state of polymers before the supramolecular self-assembly process occurs. Triton X-100 can regulate the aggregation states of conjugated polymers, which is used to successfully realize the reversible control of bactericidal activity of PFP in the dark and under white light irradiation by supramolecular assembly/disassembly between PFP and CB[7]. Specialized antibiotic switches are significantly important to fight pathogenic infections and solve the drug resistance crisis in the future.

    Copyright © 2017 American Chemical Society

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.langmuir.6b04469.

    • Experimental procedures and photographs of LB agar plates with E. coli colonies treated with 0.06% Triton X-100 with and without white light irradiation (PDF)

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    This article is cited by 45 publications.

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    Langmuir

    Cite this: Langmuir 2017, 33, 4, 1116–1120
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.langmuir.6b04469
    Published January 6, 2017
    Copyright © 2017 American Chemical Society

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