Microfluidic-Assisted Production of Size-Controlled Superparamagnetic Iron Oxide Nanoparticles-Loaded Poly(methyl methacrylate) Nanohybrids
- Shukai Ding
- ,
- Mohamed F. Attia
- ,
- Justine Wallyn
- ,
- Chiara Taddei
- ,
- Christophe A. Serra
- ,
- Nicolas Anton
- ,
- Mohamad Kassem
- ,
- Marc Schmutz
- ,
- Meriem Er-Rafik
- ,
- Nadia Messaddeq
- ,
- Alexandre Collard
- ,
- Wei Yu
- ,
- Michele Giordano
- , and
- Thierry F. Vandamme
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† Université de Strasbourg, CNRS, ICS UPR 22, F-67000 Strasbourg, France
‡ Institute of Atomic and Molecular Science, Shaanxi University of Science & Technology, CN-710021 Xi’an, Shaanxi, China
§ Université de Strasbourg, CNRS, CAMB UMR 7199, F-67000 Strasbourg, France
∥ National Research Centre, 12622 Cairo, Egypt
⊥ Department of Bioengineering, Clemson University, Clemson, South Carolina 29634, United States
# Institute for Polymers, Composites and Biomaterials (IPCB), CNR, Portici 80055, Italy
¶ Vascular and Tissue Stress in Transplantation: Microparticles and Environment EA7293, Université de Strasbourg, F-67000 Strasbourg, France
∇ Université de Strasbourg CNRS, INSERM, Collège de France, IGBMC UMR 7104/UMR_S 964, F-67000 Strasbourg, France
*E-mail: [email protected]. Phone: +33 388 414 095 (C.A.S.).
*E-mail: [email protected]. Phone: +33 368 854 251 (N.A.).
Abstract
In this paper, superparamagnetic iron oxide nanoparticles (SPIONs, around 6 nm) encapsulated in poly(methyl methacrylate) nanoparticles (PMMA NPs) with controlled sizes ranging from 100 to 200 nm have been successfully produced. The hybrid polymeric NPs were prepared following two different methods: (1) nanoprecipitation and (2) nanoemulsification–evaporation. These two methods were implemented in two different microprocesses based on the use of an impact jet micromixer and an elongational-flow microemulsifier. SPIONs-loaded PMMA NPs synthesized by the two methods presented completely different physicochemical properties. The polymeric NPs prepared with the micromixer-assisted nanoprecipitation method showed a heterogeneous dispersion of SPIONs inside the polymer matrix, an encapsulation efficiency close to 100 wt %, and an irregular shape. In contrast, the polymeric NPs prepared with the microfluidic-assisted nanoemulsification–evaporation method showed a homogeneous dispersion, an almost complete encapsulation, and a spherical shape. The properties of the polymeric NPs have been characterized by dynamic light scattering, thermogravimetric analysis, and transmission electron microscope. In vitro cytotoxicity assays were also performed on the nanohybrids and pure PMMA NPs.
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