ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Zinc Oxide Spherical-Shaped Nanostructures: Investigation of Surface Reactivity and Interactions with Microbial and Mammalian Cells

  • Diana Visinescu*
    Diana Visinescu
    “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, 060021 Bucharest, Romania
    *E-mail: [email protected] (D.V.).
  • Mohammed Dyia Hussien
    Mohammed Dyia Hussien
    Department of Botanic-Microbiology, Faculty of Biology and Research Institute of the University of Bucharest (ICUB), University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
  • Jose Calderon Moreno
    Jose Calderon Moreno
    “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, 060021 Bucharest, Romania
  • Raluca Negrea
    Raluca Negrea
    National Institute of Materials Physics, Atomistilor 105bis, 77125 Magurele, Ilfov, Romania
  • Ruxandra Birjega
    Ruxandra Birjega
    National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor, P.O. Box MG-36, 077125 Bucharest, Romania
  • Simona Somacescu
    Simona Somacescu
    “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, 060021 Bucharest, Romania
  • Cristian D. Ene
    Cristian D. Ene
    “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, 060021 Bucharest, Romania
  • Mariana Carmen Chifiriuc*
    Mariana Carmen Chifiriuc
    Department of Botanic-Microbiology, Faculty of Biology and Research Institute of the University of Bucharest (ICUB), University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
    *E-mail: [email protected] (M.C.C.).
  • Marcela Popa
    Marcela Popa
    Department of Botanic-Microbiology, Faculty of Biology and Research Institute of the University of Bucharest (ICUB), University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
    More by Marcela Popa
  • Miruna S. Stan
    Miruna S. Stan
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
  • , and 
  • Oana Carp*
    Oana Carp
    “Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Independentei, 060021 Bucharest, Romania
    *E-mail: [email protected] (O.C.).
    More by Oana Carp
Cite this: Langmuir 2018, 34, 45, 13638–13651
Publication Date (Web):October 19, 2018
https://doi.org/10.1021/acs.langmuir.8b02528
Copyright © 2018 American Chemical Society

    Article Views

    821

    Altmetric

    -

    Citations

    LEARN ABOUT THESE METRICS
    Other access options
    Supporting Info (1)»

    Abstract

    Abstract Image

    Two ZnO materials of spherical hierarchical morphologies, with hollow (ZnOHS) and solid cores (ZnOSS), were obtained through the hydrolysis of zinc acetylacetonate in 1,4-butanediol. The nature of the defects and surface reactivity for the two ZnO materials were investigated through photoluminescence, X-ray photoelectron spectroscopy, and electron paramagnetic resonance (EPR) spectroscopy proving the coexistence of shallow and deep defects and, also, the presence of polyol byproducts adsorbed on the outer layers of the ZnO samples. The EPR spectroscopy coupled with the spin-trapping technique showed that the surface of the ZnO samples generates reactive oxygen species (ROS) like hydroxyl (OH) and singlet oxygen (1O2) as well as carbon-centered radicals. The ZnO materials exhibited a wide spectrum of antimicrobial activity, being active against Gram-positive, Gram-negative, and fungi strains, both in planktonic and, more importantly, adherent growth states. The decrease of antimicrobial efficiency in the presence of a ROS scavenger (mannitol) and the decrease of the cell viability with the ROS level suggest that one of the mechanisms that governs both the antimicrobial and cytotoxic activities on human liver cells is ROS-mediated. However, at active antimicrobial concentrations, the biocompatibility of the tested materials is very good.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Supporting Information

    ARTICLE SECTIONS
    Jump To

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.langmuir.8b02528.

    • FTIR spectra for ZnOHS and ZnOSS materials; TG, DTG, and DSC curves for ZnOHS and ZnOSS samples; UV–vis spectra ZnOHS and ZnOSS materials; Tauc diagram for ZnOHS and ZnOSS materials; PXRD patterns for ZnOHS and ZnOSS materials; SEM and TEM micrographs and SAED pattern for the ZnOHS sample; TEM micrographs and SAED pattern for ZnOSS material; the O1s and C1s deconvoluted photoelectron spectra in the “as received” stage and after 0.5 min Ar+ ion etching for ZnOHS and ZnOSS materials; the EPR spectra corresponding to TEMPO radical resulted from the reaction of singlet oxygen species at the ZnOSS/water interface in the absence and in the presence of UV light; and thermal analysis for ZnOHS and ZnOSS materials (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    This article is cited by 23 publications.

    1. Chinnappa Arumugam, Gandarvakottai Senthilkumar Arumugam, Ashok Ganesan, Sarojadevi Muthusamy. Mechanical and Water Absorption Properties of Short Banana Fiber/Unsaturated Polyester/Molecular Sieves + ZnO Nanorod Hybrid Nanobiocomposites. ACS Omega 2021, 6 (51) , 35256-35271. https://doi.org/10.1021/acsomega.1c02662
    2. Nutan Rani, Sapna Yadav, Asifa Mushtaq, Swati Rani, Mona Saini, Seema Rawat, Kalpna Gupta, Kalawati Saini, Dipak Maity. Azadirachta indica peel extract-mediated synthesis of ZnO nanoparticles for antimicrobial, supercapacitor and photocatalytic applications. Chemical Papers 2024, 4 https://doi.org/10.1007/s11696-024-03340-6
    3. Ivana R. Scolari, Paulina L. Páez, Gladys E. Granero. Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic. Heliyon 2024, 182 , e25604. https://doi.org/10.1016/j.heliyon.2024.e25604
    4. Nazmi Sedefoglu. Green synthesis of ZnO nanoparticles by Myrtus communis plant extract with investigation of effect of precursor, calcination temperature and study of photocatalytic performance. Ceramics International 2024, 9 https://doi.org/10.1016/j.ceramint.2024.01.387
    5. Rodrigo Andrés Ponzio, Rusbel Coneo-Rodríguez, Tomás Miguel Mondino, M. Sergio Moreno, Gabriel Ángel Planes. Ultraviolet light–assisted synthesis of nanostructured carbon materials for supercapacitor electrodes by using zinc oxide structures as template and catalyst. Journal of Solid State Electrochemistry 2023, 47 https://doi.org/10.1007/s10008-023-05740-2
    6. Maria-Gabriela Alexandru, Adelina-Carmen Ianculescu, Oana Carp, Daniela C. Culita, Silviu Preda, Cristian D. Ene, Bogdan Stefan Vasile, Vasile-Adrian Surdu, Adrian-Ionut Nicoara, Florentina Neatu, Ioana Pintilie, Diana Visinescu. Deciphering the role of water and a zinc-doping process in a polyol-based approach for obtaining Zn/Co/Al-based spinels: toward “green” mesoporous inorganic pigments. Dalton Transactions 2023, 52 (30) , 10386-10401. https://doi.org/10.1039/D3DT00972F
    7. Cecilia Lete, Adela-Maria Spinciu, Maria-Gabriela Alexandru, Jose Calderon Moreno, Sorina-Alexandra Leau, Mariana Marin, Diana Visinescu. Copper(II) Oxide Nanoparticles Embedded within a PEDOT Matrix for Hydrogen Peroxide Electrochemical Sensing. Sensors 2022, 22 (21) , 8252. https://doi.org/10.3390/s22218252
    8. Cristian D. Ene, Paula Cucos, Adelina Ianculescu, Daniela C. Culita, Elena Maria Anghel, Andrei Cucos, Irina Atkinson, Mariana Carmen Chifiriuc, José Maria Calderón-Moreno, Oana Carp. Benign by design: porous spherical ZnO-alginate family via a dual-template synthesis. Applied Surface Science 2022, 580 , 152231. https://doi.org/10.1016/j.apsusc.2021.152231
    9. Koteeswara Reddy Nandanapalli, Devika Mudusu, Ramesh Karuppannan, Yoon-Bong Hahn, Sungwon Lee. Predominantly enhanced catalytic activities of surface protected ZnO nanorods integrated stainless-steel mesh structures: A synergistic impact on oxygen evolution reaction process. Chemical Engineering Journal 2022, 429 , 132360. https://doi.org/10.1016/j.cej.2021.132360
    10. M Saini, A Mushtaq, S Yadav, S Rawat, Nutan Rani, K Gupta, K Saini. Green Synthesis of Rod Shaped ZnO using Extract of Origanum majorana Leaf and Investigation for Antibacterial Applications. IOP Conference Series: Materials Science and Engineering 2022, 1225 (1) , 012048. https://doi.org/10.1088/1757-899X/1225/1/012048
    11. Sujittra Kaenphakdee, Pimpaka Putthithanas, Supan Yodyingyong, Jeerapond Leelawattanachai, Wannapong Triampo, Noppakun Sanpo, Jaturong Jitputti, Darapond Triampo. Zinc Oxide Synthesis from Extreme Ratios of Zinc Acetate and Zinc Nitrate: Synergistic Morphology. Materials 2022, 15 (2) , 570. https://doi.org/10.3390/ma15020570
    12. Manaf Olongal, Leya Rose Raphael, Prasanth Raghavan, Mohamed Ansari Mohamed Nainar, Sujith Athiyanathil. Maleic anhydride grafted acrylonitrile butadiene styrene (ABS)/zinc oxide nanocomposite: an anti-microbial material. Journal of Polymer Research 2021, 28 (8) https://doi.org/10.1007/s10965-021-02632-9
    13. Veronica Lazar, Alina Maria Holban, Carmen Curutiu, Mariana Carmen Chifiriuc. Modulation of Quorum Sensing and Biofilms in Less Investigated Gram-Negative ESKAPE Pathogens. Frontiers in Microbiology 2021, 12 https://doi.org/10.3389/fmicb.2021.676510
    14. Leila Jameie, Alireza Shahzeydi, Mehran Ghiaci, Mingxuan Sun. Designing an efficient heterogeneous photo-catalyst based on ZnO nanoparticles as support in a carbonaceous network. Journal of Environmental Chemical Engineering 2021, 9 (2) , 105086. https://doi.org/10.1016/j.jece.2021.105086
    15. J. Saranya, B. S. Sreeja, G. Padmalaya, S. Radha, M. Arivanandan. Microwave Thermally Assisted Porous Structured Cerium Oxide/Zinc Oxide Design: Fabrication, Electrochemical Activity Towards Pb Ions, Anticancer Assessment in HeLa and VERO Cell Lines. Journal of Inorganic and Organometallic Polymers and Materials 2021, 31 (3) , 1279-1292. https://doi.org/10.1007/s10904-020-01809-x
    16. Eva Albalghiti, Lisa M. Stabryla, Leanne M. Gilbertson, Julie B. Zimmerman. Towards resolution of antibacterial mechanisms in metal and metal oxide nanomaterials: a meta-analysis of the influence of study design on mechanistic conclusions. Environmental Science: Nano 2021, 8 (1) , 37-66. https://doi.org/10.1039/D0EN00949K
    17. Khalid A. Alamry, Samar J. Almehmadi, M.A. Elfaky, H. F. Al-Shareef, Samah J. A., Mahmoud A. Hussein. Enhanced antimicrobial activity of new arylidene-based polyketone nanocomposite materials. Polymer-Plastics Technology and Materials 2020, 59 (18) , 1973-1986. https://doi.org/10.1080/25740881.2020.1784213
    18. Yan Bao, Yan Yan, Jianzhong Ma, Wenbo Zhang, Yan Zong. ZnO encapsulants: Design and new view. Advances in Colloid and Interface Science 2020, 283 , 102238. https://doi.org/10.1016/j.cis.2020.102238
    19. Ning Ding, Yajuan Sun, Binhe Chen, Dandi Wang, Shengnan Tao, Bingtian Zhao, Yunxing Li. Facile preparation of raspberry-like PS/ZnO composite particles and their antibacterial properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2020, 599 , 124867. https://doi.org/10.1016/j.colsurfa.2020.124867
    20. M. Montero-Muñoz, J. E. Ramos-Ibarra, J. E. Rodríguez-Páez, G. E. Marques, M. D. Teodoro, J. A. H. Coaquira. Growth and formation mechanism of shape-selective preparation of ZnO structures: correlation of structural, vibrational and optical properties. Physical Chemistry Chemical Physics 2020, 22 (14) , 7329-7339. https://doi.org/10.1039/C9CP06744B
    21. Aftab Ahmad, Sadeeq Ullah, Waqas Ahmad, Qipeng Yuan, Raheela Taj, Arif Ullah Khan, Aziz Ur Rahman, Usman Ali Khan. Zinc oxide‑selenium heterojunction composite: Synthesis, characterization and photo-induced antibacterial activity under visible light irradiation. Journal of Photochemistry and Photobiology B: Biology 2020, 203 , 111743. https://doi.org/10.1016/j.jphotobiol.2019.111743
    22. Greta Patrinoiu, Raluca Dumitru, Dana C. Culita, Cornel Munteanu, Ruxandra Birjega, José M. Calderon-Moreno, Andrei Cucos, Diana Pelinescu, Mariana C. Chifiriuc, Coralia Bleotu, Oana Carp. Self-assembled zinc oxide hierarchical structures with enhanced antibacterial properties from stacked chain-like zinc oxalate compounds. Journal of Colloid and Interface Science 2019, 552 , 258-270. https://doi.org/10.1016/j.jcis.2019.05.051
    23. Greta Patrinoiu, Mohammed Dyia Hussien, José Maria Calderón-Moreno, Irina Atkinson, Adina M. Musuc, Raluca N. Ion, Anisoara Cimpean, Mariana C. Chifiriuc, Oana Carp. Eco-friendly synthesized spherical ZnO materials: Effect of the core-shell to solid morphology transition on antimicrobial activity. Materials Science and Engineering: C 2019, 97 , 438-450. https://doi.org/10.1016/j.msec.2018.12.063

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect