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Micromotors as “Motherships”: A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via Nanoparticles
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    Micromotors as “Motherships”: A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via Nanoparticles
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    • Tomáš Kroupa
      Tomáš Kroupa
      Department of Polymers, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
    • Soňa Hermanová
      Soňa Hermanová
      Department of Polymers, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
      Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
    • Carmen C. Mayorga-Martinez
      Carmen C. Mayorga-Martinez
      Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
    • Filip Novotný
      Filip Novotný
      Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
    • Zdeněk Sofer
      Zdeněk Sofer
      Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
    • Martin Pumera*
      Martin Pumera
      Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
      Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
      Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, Brno, CZ-616 00, Czech Republic
      *E-mail: [email protected]
    Other Access OptionsSupporting Information (5)

    Langmuir

    Cite this: Langmuir 2019, 35, 32, 10618–10624
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    https://doi.org/10.1021/acs.langmuir.9b01192
    Published July 19, 2019
    Copyright © 2019 American Chemical Society

    Abstract

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    Nano/micromotors based on biodegradable and biocompatible polymers represent a progressively developing group of self-propelled artificial devices capable of delivering biologically active compounds to target sites. The majority of these machines are micron sized, and biologically active compounds are simply attached to their surface. Micron-sized devices cannot enter cells, but they provide rapid velocity, which scales down with the size of the device; nanosized devices can enter cells, but their velocity is negligible. An advanced hierarchical design of the micro/nanodevices is an important tool in the development of functional biocompatible transport systems and their implementation in real in vivo applications. In this work, we demonstrate a “mothership” concept, whereby self-propelled microrobots transport smaller cargo-carrying nanorobots that are released by enzymatic degradation.

    Copyright © 2019 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.langmuir.9b01192.

    • Polymerization results, 1NMR spectrum of OH-PCL-SH, images of micromotors taken by optical profilometer (PDF)

    • Representative trajectories of the micromotors at H2O2 concentration of 1 wt % (MP4)

    • Representative trajectories of the micromotors at H2O2 concentration of 10 wt % (MP4)

    • Micromotors before the cargo loading (MP4)

    • Micromotors during the cargo transport (MP4)

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    Cited By

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    Citation Statements
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    This article is cited by 18 publications.

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    2. Larisa B. Gulina, Vladislav E. Gurenko, Valeri P. Tolstoy, Vladimir Yu Mikhailovskii, Alexandra V. Koroleva. Interface-Assisted Synthesis of the Mn3–xFexO4 Gradient Film with Multifunctional Properties. Langmuir 2019, 35 (47) , 14983-14989. https://doi.org/10.1021/acs.langmuir.9b02338
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    7. Ke Xu, Jindun Zhou. Drug Deliery for Micro-/Nanorobots: Progress and Challenges. Current Nanoscience 2022, 18 (6) , 690-699. https://doi.org/10.2174/1573413718666220127123038
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    18. Emil Karshalev, Jieming Yan, Isaac Campos, Elodie Sandraz, Jinxing Li, Joseph Wang. Small‐Scale Propellers Deliver Miniature Versions of Themselves. Small 2020, 16 (17) https://doi.org/10.1002/smll.202000453

    Langmuir

    Cite this: Langmuir 2019, 35, 32, 10618–10624
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.langmuir.9b01192
    Published July 19, 2019
    Copyright © 2019 American Chemical Society

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