Micromotors as “Motherships”: A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via NanoparticlesClick to copy article linkArticle link copied!
- Tomáš KroupaTomáš KroupaDepartment of Polymers, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech RepublicMore by Tomáš Kroupa
- Soňa HermanováSoňa HermanováDepartment of Polymers, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech RepublicCenter for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech RepublicMore by Soňa Hermanová
- Carmen C. Mayorga-MartinezCarmen C. Mayorga-MartinezCenter for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech RepublicMore by Carmen C. Mayorga-Martinez
- Filip NovotnýFilip NovotnýCenter for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech RepublicMore by Filip Novotný
- Zdeněk SoferZdeněk SoferCenter for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech RepublicMore by Zdeněk Sofer
- Martin Pumera*Martin Pumera*E-mail: [email protected]Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech RepublicDepartment of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaFuture Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, Brno, CZ-616 00, Czech RepublicMore by Martin Pumera
Abstract

Nano/micromotors based on biodegradable and biocompatible polymers represent a progressively developing group of self-propelled artificial devices capable of delivering biologically active compounds to target sites. The majority of these machines are micron sized, and biologically active compounds are simply attached to their surface. Micron-sized devices cannot enter cells, but they provide rapid velocity, which scales down with the size of the device; nanosized devices can enter cells, but their velocity is negligible. An advanced hierarchical design of the micro/nanodevices is an important tool in the development of functional biocompatible transport systems and their implementation in real in vivo applications. In this work, we demonstrate a “mothership” concept, whereby self-propelled microrobots transport smaller cargo-carrying nanorobots that are released by enzymatic degradation.
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(1)
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(47)
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