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Self-Assembly of Copolyesters into Stereocomplex Crystallites Tunes the Properties of Polyester Nanoparticles

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    Self-Assembly of Copolyesters into Stereocomplex Crystallites Tunes the Properties of Polyester Nanoparticles
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    • Karl Scheuer
      Karl Scheuer
      Chair of Materials Science (CMS), Department of Materials Science and Technology, Otto Schott Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Löbdergraben 32, Jena 07743, Germany
      More by Karl Scheuer
    • Damiano Bandelli
      Damiano Bandelli
      Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany
      Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena 07743, Germany
      More by Damiano Bandelli
      Orcidhttp://orcid.org/0000-0002-9968-2560
    • Christian Helbing
      Christian Helbing
      Chair of Materials Science (CMS), Department of Materials Science and Technology, Otto Schott Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Löbdergraben 32, Jena 07743, Germany
      More by Christian Helbing
    • Christine Weber
      Christine Weber
      Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany
      Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena 07743, Germany
      More by Christine Weber
      Orcidhttp://orcid.org/0000-0003-0712-5255
    • Julien Alex
      Julien Alex
      Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany
      Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena 07743, Germany
      More by Julien Alex
    • Johannes B. Max
      Johannes B. Max
      Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany
      Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena 07743, Germany
      More by Johannes B. Max
    • Alexis Hocken
      Alexis Hocken
      Chair of Materials Science (CMS), Department of Materials Science and Technology, Otto Schott Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Löbdergraben 32, Jena 07743, Germany
      More by Alexis Hocken
    • Ondrej Stranik
      Ondrej Stranik
      Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, Jena 07743, Germany
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      Orcidhttp://orcid.org/0000-0001-8995-8132
    • Lisa Seiler
      Lisa Seiler
      Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, Jena 07743, Germany
      Institute of Physical Chemistry and Abbe School of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, Jena 07743, Germany
      More by Lisa Seiler
    • Frederike Gladigau
      Frederike Gladigau
      Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, Jena 07743, Germany
      Institute of Physical Chemistry and Abbe School of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, Jena 07743, Germany
      More by Frederike Gladigau
    • Ute Neugebauer
      Ute Neugebauer
      Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany
      Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, Jena 07743, Germany
      Institute of Physical Chemistry and Abbe School of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, Jena 07743, Germany
      Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum 1, Jena 07747, Germany
      More by Ute Neugebauer
    • Felix H. Schacher
      Felix H. Schacher
      Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany
      Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena 07743, Germany
      More by Felix H. Schacher
      Orcidhttp://orcid.org/0000-0003-4685-6608
    • Ulrich S. Schubert*
      Ulrich S. Schubert
      Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, Jena 07743, Germany
      Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena 07743, Germany
      *Email: [email protected]
      More by Ulrich S. Schubert
      Orcidhttp://orcid.org/0000-0003-4978-4670
    • Klaus D. Jandt*
      Klaus D. Jandt
      Chair of Materials Science (CMS), Department of Materials Science and Technology, Otto Schott Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Löbdergraben 32, Jena 07743, Germany
      Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena 07743, Germany
      *Email: [email protected]
      More by Klaus D. Jandt
      Orcidhttp://orcid.org/0000-0002-7537-5603
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    Macromolecules

    Cite this: Macromolecules 2020, 53, 19, 8340–8351
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.macromol.0c01247
    Published October 2, 2020
    Copyright © 2020 American Chemical Society
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    Abstract

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    Self-assembly of polyesters like PlLA and PdLA into stereocomplexes (SCs) is an interesting approach to tailor physical properties of polymeric nanoparticles without affecting their hydrophilicity. Here, we use the stereocomplexation of P(lLA-stat-EtGly) and P(dLA-stat-EtGly) (EtGly: 3-ethylglycolide) to tune the melting temperature (Tm) and degree of crystallinity (wc) of the bulk polymer. Using time-dependent blending experiments and characterization techniques, such as dynamic light scattering, wide-angle X-ray spectroscopy, differential scanning calorimetry, and atomic force microscopy, we tested the hypothesis that the amount of SCs within the nanoparticles impacts their mechanical properties. Our results show that Tm and wc can be adjusted via the EtGly content. Interestingly, mechanical properties of the nanoparticles depend on the EtGly content as well as the self-assembly time of SCs before nanoparticle formation. This offers a high potential for their application in drug delivery, where their tunable properties will allow to adjust degradation and drug release behavior.

    Copyright © 2020 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.macromol.0c01247.

    • DSC thermograms of pure P(lLA-stat-EtGly), pure P(dLA-stat-EtGly), and SCs containing 0–20 mol % EtGly, WAXS patterns for P(lLA-stat-EtGly) containing 0–20 mol % EtGly and pure PEtGly, DLS data and AFM images of time-dependent SC formation in THF, ELS, and DLS data of SC containing nanoparticles, AFM images and Young’s moduli of SC containing nanoparticles, Tm and wc values for the noncomplexed copolymers, and Raman data of the bulk material, dried nanoparticles, and nanoparticles in dispersion (PDF)

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    This article is cited by 14 publications.

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    7. Rose Mary Michell, Viko Ladelta, Edgar Da Silva, Alejandro J Müller, Nikos Hadjichristidis. Poly(lactic acid) stereocomplexes based molecular architectures: Synthesis and crystallization. Progress in Polymer Science 2023, 146 , 101742. https://doi.org/10.1016/j.progpolymsci.2023.101742
    8. Mingwei Guo, Weixin Wu, Wenjing Wu, Ruizhe Wang, Liming Huang, Qinwei Gao. Recent advances in enhancing stereocomplexation between poly(lactide) enantiomeric chains. Physical Chemistry Chemical Physics 2023, 25 (27) , 17737-17758. https://doi.org/10.1039/D3CP01003A
    9. Mohammad Raef, Jose-Ramon Sarasua, Agustin Etxeberria, Jone M. Ugartemendia. Stereocomplexation: From molecular structure to functionality of advanced polylactide systems. Polymer 2023, 280 , 126066. https://doi.org/10.1016/j.polymer.2023.126066
    10. Mohammed Alhaj, Ramani Narayan. Scalable Continuous Manufacturing Process of Stereocomplex PLA by Twin-Screw Extrusion. Polymers 2023, 15 (4) , 922. https://doi.org/10.3390/polym15040922
    11. Neha Mulchandani, Yoshiharu Kimura, Vimal Katiyar. PREPARATION, STRUCTURE, AND PROPERTIES OF STEREOCOMPLEX‐TYPE POLY(LACTIC ACID). 2022, 73-86. https://doi.org/10.1002/9781119767480.ch5
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    14. Seung Hyuk Im, Dam Hyeok Im, Su Jeong Park, Justin Jihong Chung, Youngmee Jung, Soo Hyun Kim. Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review. Molecules 2021, 26 (10) , 2846. https://doi.org/10.3390/molecules26102846
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    Macromolecules

    Cite this: Macromolecules 2020, 53, 19, 8340–8351
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.macromol.0c01247
    Published October 2, 2020
    Copyright © 2020 American Chemical Society
    Request reuse permissions

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