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Ultrasonic Control of Neural Activity through Activation of the Mechanosensitive Channel MscL

  • Jia Ye
    Jia Ye
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Jia Ye
  • Siyang Tang
    Siyang Tang
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Siyang Tang
  • Long Meng
    Long Meng
    Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518005, China
    More by Long Meng
  • Xia Li
    Xia Li
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Xia Li
  • Xiaoxu Wen
    Xiaoxu Wen
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Xiaoxu Wen
  • Sihan Chen
    Sihan Chen
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Sihan Chen
  • Lili Niu
    Lili Niu
    Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518005, China
    More by Lili Niu
  • Xiangyao Li
    Xiangyao Li
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Xiangyao Li
  • Weibao Qiu
    Weibao Qiu
    Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518005, China
    More by Weibao Qiu
  • Hailan Hu
    Hailan Hu
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Hailan Hu
  • Mizu Jiang
    Mizu Jiang
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Mizu Jiang
  • Shiqiang Shang
    Shiqiang Shang
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
  • Qiang shu
    Qiang shu
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Qiang shu
  • Hairong Zheng*
    Hairong Zheng
    Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518005, China
    *E-mail: [email protected]
  • Shumin Duan
    Shumin Duan
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    More by Shumin Duan
  • , and 
  • Yuezhou Li*
    Yuezhou Li
    Children’s Hospital and Department of Biophysics, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    *E-mail: [email protected]
    More by Yuezhou Li
Cite this: Nano Lett. 2018, 18, 7, 4148–4155
Publication Date (Web):June 19, 2018
https://doi.org/10.1021/acs.nanolett.8b00935
Copyright © 2018 American Chemical Society

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    Abstract

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    Externally controlling the excitation of a neuronal subset through ion channels activation can modulate the firing pattern of an entire neural circuit in vivo. As nanovalves in the cell membrane, ion channels can be opened by light (optogenetics) or ultrasonic (sonogenetics) means. A thoroughly analyzed force sensor is the Escherichia colimechanosensitive channel of large conductance (MscL). Here we expressed MscL in rat hippocampal neurons in a primary culture and showed that it could be activated by low-pressure ultrasound pulses. The gain-of-function mutation, I92L, sensitized MscL’s sonic response, triggering action potentials at a peak negative pressure as low as 0.25 MPa. Further, the I92L MscL reliably elicited individual spikes by timed brief pulses, making excitation programmable. Because MscL opens to tension in the lipid bilayer, requiring no other proteins or ligands, it could be developed into a general noninvasive sonogenetic tool to manipulate the activities of neurons or other cells and potential nanodevices.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.nanolett.8b00935.

    • Expression of MscL has minimal effects on membrane properties; none of ultrasound-induced activations were detected in early days of cultured hippocampal cells; no effect of ultrasound on background mCherry fluorescence; calcein flux though gated I92L channels; ultrasound-induced activation was independent of the amount of buffer used in the surface-acoustic-wave-based ultrasound device (PDF)

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    3. Athanasios G. Athanassiadis, Zhichao Ma, Nicolas Moreno-Gomez, Kai Melde, Eunjin Choi, Rahul Goyal, Peer Fischer. Ultrasound-Responsive Systems as Components for Smart Materials. Chemical Reviews 2022, 122 (5) , 5165-5208. https://doi.org/10.1021/acs.chemrev.1c00622
    4. Yuxia Liu, Zhigao Yi, Yun Yao, Bing Guo, Xiaogang Liu. Noninvasive Manipulation of Ion Channels for Neuromodulation and Theranostics. Accounts of Materials Research 2022, 3 (2) , 247-258. https://doi.org/10.1021/accountsmr.1c00251
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    8. Kai Wu, Diqing Su, Renata Saha, Jian-Ping Wang. Spin–Orbit Torque and Spin Hall Effect-Based Cellular Level Therapeutic Spintronic Neuromodulator: A Simulation Study. The Journal of Physical Chemistry C 2019, 123 (40) , 24963-24972. https://doi.org/10.1021/acs.jpcc.9b07542
    9. Fangzhen Shan, Nannan Zhang, Xiaoying Yao, Yi Li, Zihao Wang, Chuanji Zhang, Yuzhong Wang. Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells. Cell Communication and Signaling 2024, 22 (1) https://doi.org/10.1186/s12964-024-01497-x
    10. Alfonso Enrique Martinez-Nunez, Maria Belen Justich, Michael S. Okun, Alfonso Fasano. Emerging therapies for neuromodulation in Parkinson's disease. Neurotherapeutics 2024, 21 (3) , e00310. https://doi.org/10.1016/j.neurot.2023.e00310
    11. Rui Feng, Hanqing Sheng, Yajun Lian. Advances in using ultrasound to regulate the nervous system. Neurological Sciences 2024, 127 https://doi.org/10.1007/s10072-024-07426-7
    12. Junru Yuan, Yi Li, Meng Wang, Xiaodi Huang, Tao Zhang, Kan‐Hao Xue, Junhui Yuan, Jun Ou‐Yang, Xiaofei Yang, Xiangshui Miao, Benpeng Zhu. Ultrasound: A new strategy for artificial synapses modulation. InfoMat 2024, 3 https://doi.org/10.1002/inf2.12528
    13. Johannes Hahmann, Aman Ishaqat, Twan Lammers, Andreas Herrmann. Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound. Angewandte Chemie International Edition 2024, 23 https://doi.org/10.1002/anie.202317112
    14. Johannes Hahmann, Aman Ishaqat, Twan Lammers, Andreas Herrmann. Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound. Angewandte Chemie 2024, 23 https://doi.org/10.1002/ange.202317112
    15. Ze-Qing Liu, Xiang-Yang Yu, Jing Huang, Xin-Yi Wu, Zi-Yu Wang, Ben-Peng Zhu. A review: flexible devices for nerve stimulation. Soft Science 2024, 4 (1) https://doi.org/10.20517/ss.2023.36
    16. Wen Meng, Zhengrong Lin, Tianyuan Bian, Xiaoyan Chen, Long Meng, Tifei Yuan, Lili Niu, Hairong Zheng. Ultrasound Deep Brain Stimulation Regulates Food Intake and Body Weight in Mice. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2024, 32 , 366-377. https://doi.org/10.1109/TNSRE.2024.3351312
    17. Ben Fu, Dandan Shan, Cong Pu, Lehang Guo, Huixiong Xu, Chang Peng. A Systematic Investigation of Thermal Effects of High-Intensity Focused Ultrasound Therapy for Ultrasound Neuromodulation. IEEE Transactions on Instrumentation and Measurement 2024, 73 , 1-12. https://doi.org/10.1109/TIM.2024.3366278
    18. Hsien-Chu Wang, Thi-Nhan Phan, Chi-Ling Kao, Chih-Kuang Yeh, Yu-Chun Lin. Genetically encoded mediators for sonogenetics and their applications in neuromodulation. Frontiers in Cellular Neuroscience 2023, 17 https://doi.org/10.3389/fncel.2023.1326279
    19. Zhenya Zhu, Xiaolong Chen, Shuang Chen, Chenmin Hu, Rui Guo, Yuhao Wu, Ziyu Liu, Xiaoli Shu, Mizu Jiang. Examination of the mechanism of Piezo ion channel in 5-HT synthesis in the enterochromaffin cell and its association with gut motility. Frontiers in Endocrinology 2023, 14 https://doi.org/10.3389/fendo.2023.1193556
    20. Siyi Zhuang, Mubin He, Jiaqi Feng, Shiyi Peng, Haochen Jiang, Yunhao Li, Ning Hua, Yujie Zheng, Qizhen Ye, Miaojin Hu, Ying Nie, Peilin Yu, Xiaomin Yue, Jun Qian, Wei Yang. Near‐Infrared Photothermal Manipulates Cellular Excitability and Animal Behavior in Caenorhabditis elegans. Small Methods 2023, 7 (11) https://doi.org/10.1002/smtd.202300848
    21. Jialu Li, Chengheng Wu, Mingze Zeng, Yusheng Zhang, Dan Wei, Jing Sun, Hongsong Fan. Functional material-mediated wireless physical stimulation for neuro-modulation and regeneration. Journal of Materials Chemistry B 2023, 11 (38) , 9056-9083. https://doi.org/10.1039/D3TB01354E
    22. Huixian Chang, Qian Wang, Taotao Liu, Lei Chen, Jingshu Hong, Kaixi Liu, Yitong Li, Ning Yang, Dengyang Han, Xinning Mi, Xiaoli Li, Xiangyang Guo, Yingwei Li, Zhengqian Li. A Bibliometric Analysis for Low‐Intensity Ultrasound Study Over the Past Three Decades. Journal of Ultrasound in Medicine 2023, 42 (10) , 2215-2232. https://doi.org/10.1002/jum.16245
    23. Wu Yong, Dongming He, Taiheng Chen, Zeng Rui, Yinchuan Wen, Kin Fung Wong, Lei Sun, Xiaofei Qi, Jinghui Guo. Activation of N-Methyl-D-aspartate receptor contributed to the ultrasonic modulation of neurons in vitro. Biochemical and Biophysical Research Communications 2023, 676 , 42-47. https://doi.org/10.1016/j.bbrc.2023.07.034
    24. Kama Bell, Hyeonu Heo, Yun Jing. Sonogenetics: a mini review. Frontiers in Acoustics 2023, 1 https://doi.org/10.3389/facou.2023.1269867
    25. Lulu Wang, Guanglei Chang, Miaomiao Yang, Zhaobin Xu, Jianye Wang, Hongliang Xu, Meixia He, Liping Dai, Yang Zhao, Zhenyu Ji, Liguo Zhang. The Noninvasive Sonothermogenetics Used for Neuromodulation in M1 Region of Mice Brain by Overexpression of TRPV1. Neuroscience 2023, 527 , 22-36. https://doi.org/10.1016/j.neuroscience.2023.07.019
    26. Mengyao Song, Mingxia Zhang, Sixuan He, Le Li, Huijing Hu. Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future. Frontiers in Neuroscience 2023, 17 https://doi.org/10.3389/fnins.2023.1232308
    27. Yukio Imamura, Hisatake Matsumoto, Jun Imamura, Naoya Matsumoto, Kazuma Yamakawa, Nao Yoshikawa, Yuki Murakami, Satoko Mitani, Junichiro Nakagawa, Tomoki Yamada, Hiroshi Ogura, Jun Oda, Takeshi Shimazu. Ultrasound stimulation of the vagal nerve improves acute septic encephalopathy in mice. Frontiers in Neuroscience 2023, 17 https://doi.org/10.3389/fnins.2023.1211608
    28. Weihua Yuan, Xicheng Zhang, Xiangming Fan. The Role of the Piezo1 Mechanosensitive Channel in Heart Failure. Current Issues in Molecular Biology 2023, 45 (7) , 5830-5848. https://doi.org/10.3390/cimb45070369
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    30. Lizebona August Ambattu, Leslie Y. Yeo. Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications. Biophysics Reviews 2023, 4 (2) https://doi.org/10.1063/5.0127122
    31. Quanxiang Xian, Zhihai Qiu, Suresh Murugappan, Shashwati Kala, Kin Fung Wong, Danni Li, Guofeng Li, Yizhou Jiang, Yong Wu, Min Su, Xuandi Hou, Jiejun Zhu, Jinghui Guo, Weibao Qiu, Lei Sun. Modulation of deep neural circuits with sonogenetics. Proceedings of the National Academy of Sciences 2023, 120 (22) https://doi.org/10.1073/pnas.2220575120
    32. Yaya Zhang, Na Pang, Xiaowei Huang, Wen Meng, Long Meng, Bingchang Zhang, Zhengye Jiang, Jing Zhang, Zhou Yi, Zhiyu Luo, Zhanxiang Wang, Lili Niu. Ultrasound deep brain stimulation decelerates telomere shortening in Alzheimer's disease and aging mice. Fundamental Research 2023, 3 (3) , 469-478. https://doi.org/10.1016/j.fmre.2022.02.010
    33. Zhaocheng Su, Jiaqing Yan, Hui Ji, Mengyang Liu, Xiangjian Zhang, Xiaoli Li, Yi Yuan. Time–frequency cross-coupling between cortical low-frequency neuronal calcium oscillations and blood oxygen metabolism evoked by ultrasound stimulation. Cerebral Cortex 2023, 33 (8) , 4665-4676. https://doi.org/10.1093/cercor/bhac370
    34. Qiwen Huang, Weisheng Zhu, Xiaoyin Gao, Xinping Liu, Zhijun Zhang, Bengang Xing. Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications. Advanced Drug Delivery Reviews 2023, 195 , 114763. https://doi.org/10.1016/j.addr.2023.114763
    35. Shaoqing Ma, Zhiwei Li, Shixiang Gong, Chengbiao Lu, Xiaoli Li, Yingwei Li. High Frequency Electromagnetic Radiation Stimulates Neuronal Growth and Hippocampal Synaptic Transmission. Brain Sciences 2023, 13 (4) , 686. https://doi.org/10.3390/brainsci13040686
    36. Yi Yuan, Qianqian Wu, Xingran Wang, Mengyang Liu, Jiaqing Yan, Hui Ji. Low-intensity ultrasound stimulation modulates time-frequency patterns of cerebral blood oxygenation and neurovascular coupling of mouse under peripheral sensory stimulation state. NeuroImage 2023, 270 , 119979. https://doi.org/10.1016/j.neuroimage.2023.119979
    37. Yun-Yun Hu, Gang Yang, Xue-Song Liang, Xuan-Si Ding, De-En Xu, Zhe Li, Quan-Hong Ma, Rui Chen, Yan-Yun Sun. Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application. Frontiers in Neurology 2023, 14 https://doi.org/10.3389/fneur.2023.1117188
    38. Xiaoxu Wen, Yingying Wang, Zhenya Zhu, Shuangshuang Guo, Junjie Qian, Jinjun Zhu, Zhenni Yang, Weibao Qiu, Guofeng Li, Li Huang, Mizu Jiang, Linhua Tan, Hairong Zheng, Qiang Shu, Yuezhou Li. Mechanosensitive channel MscL induces non-apoptotic cell death and its suppression of tumor growth by ultrasound. Frontiers in Chemistry 2023, 11 https://doi.org/10.3389/fchem.2023.1130563
    39. Reza Rasouli, Karina Martinez Villegas, Maryam Tabrizian. Acoustofluidics – changing paradigm in tissue engineering, therapeutics development, and biosensing. Lab on a Chip 2023, 23 (5) , 1300-1338. https://doi.org/10.1039/D2LC00439A
    40. Wei Wei, Yaping Wang, Zhaoxun Wang, Xuexin Duan. Microscale acoustic streaming for biomedical and bioanalytical applications. TrAC Trends in Analytical Chemistry 2023, 160 , 116958. https://doi.org/10.1016/j.trac.2023.116958
    41. Meng Du, Ting Wang, Renjie Feng, Penghui Zeng, Zhiyi Chen. Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release. Frontiers in Bioengineering and Biotechnology 2023, 11 https://doi.org/10.3389/fbioe.2023.1144963
    42. Michael N. Young, Michael J. Sindoni, Amanda H. Lewis, Stefan Zauscher, Jörg Grandl. The energetics of rapid cellular mechanotransduction. Proceedings of the National Academy of Sciences 2023, 120 (8) https://doi.org/10.1073/pnas.2215747120
    43. Kevin Xu, Yaoheng Yang, Zhongtao Hu, Yimei Yue, Yan Gong, Jianmin Cui, Joseph P Culver, Michael R Bruchas, Hong Chen. TRPV1-mediated sonogenetic neuromodulation of motor cortex in freely moving mice. Journal of Neural Engineering 2023, 20 (1) , 016055. https://doi.org/10.1088/1741-2552/acbba0
    44. Nicholas White, Shelly Sakiyama-Elbert. Spinal interneurons and cellular engineering. 2023, 423-444. https://doi.org/10.1016/B978-0-12-819260-3.00004-4
    45. Haiming Fan. Central Nervous System Nanotechnology. 2023, 655-692. https://doi.org/10.1007/978-981-16-8984-0_29
    46. Hairong Zheng, Lili Niu, Weibao Qiu, Dong Liang, Xiaojing Long, Guanglin Li, Zhiyuan Liu, Long Meng. The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface. Research 2023, 6 https://doi.org/10.34133/research.0200
    47. Hairong Zheng, Lili Niu, Chunyan Liu, Tingting Zhang. Transcranial Ultrasonic Neurostimulation. 2023, 177-185. https://doi.org/10.1007/978-981-99-4538-2_11
    48. Marc Duque, Corinne A. Lee-Kubli, Yusuf Tufail, Uri Magaram, Janki Patel, Ahana Chakraborty, Jose Mendoza Lopez, Eric Edsinger, Aditya Vasan, Rani Shiao, Connor Weiss, James Friend, Sreekanth H. Chalasani. Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels. Nature Communications 2022, 13 (1) https://doi.org/10.1038/s41467-022-28205-y
    49. Shuxun Dong, Jiaqing Yan, Zhenyu Xie, Yi Yuan, Hui Ji. Modulation effect of mouse hippocampal neural oscillations by closed-loop transcranial ultrasound stimulation. Journal of Neural Engineering 2022, 19 (6) , 066038. https://doi.org/10.1088/1741-2552/aca799
    50. Morgan N. Collins, Karen A. Mesce. A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach. Frontiers in Physiology 2022, 13 https://doi.org/10.3389/fphys.2022.1047324
    51. Andrea Francovich, Sara Raimondi, Loredana Marchese, Alma Baruffaldi, Sofia Giorgetti, Giulia Matrone. An Analysis of Ultrasound Stimulation Effects on C. Elegans Organisms Motility. 2022, 1-4. https://doi.org/10.1109/IUS54386.2022.9957328
    52. Ya-Cherng Chu, Jormay Lim, Andy Chien, Chih-Cheng Chen, Jaw-Lin Wang. Activation of Mechanosensitive Ion Channels by Ultrasound. Ultrasound in Medicine & Biology 2022, 48 (10) , 1981-1994. https://doi.org/10.1016/j.ultrasmedbio.2022.06.008
    53. Zhenyu Xie, Jiaqing Yan, Shuxun Dong, Hui Ji, Yi Yuan. Phase-locked closed-loop ultrasound stimulation modulates theta and gamma rhythms in the mouse hippocampus. Frontiers in Neuroscience 2022, 16 https://doi.org/10.3389/fnins.2022.994570
    54. Tianyi Liu, Mi Hyun Choi, Jiejun Zhu, Tingting Zhu, Jin Yang, Na Li, Zihao Chen, Quanxiang Xian, Xuandi Hou, Dongmin He, Jinghui Guo, Chunlong Fei, Lei Sun, Zhihai Qiu. Sonogenetics: Recent advances and future directions. Brain Stimulation 2022, 15 (5) , 1308-1317. https://doi.org/10.1016/j.brs.2022.09.002
    55. Bing Chen, Meihui Cui, Yuan Wang, Peng Shi, Hanjie Wang, Feng Wang. Recent advances in cellular optogenetics for photomedicine. Advanced Drug Delivery Reviews 2022, 188 , 114457. https://doi.org/10.1016/j.addr.2022.114457
    56. Jaya Dilip Badadhe, Hyeonhee Roh, Byung Chul Lee, Jae Hun Kim, Maesoon Im. Ultrasound stimulation for non-invasive visual prostheses. Frontiers in Cellular Neuroscience 2022, 16 https://doi.org/10.3389/fncel.2022.971148
    57. Uri Magaram, Connor Weiss, Aditya Vasan, Kirthi C. Reddy, James Friend, Sreekanth H. Chalasani, . Two pathways are required for ultrasound-evoked behavioral changes in Caenorhabditis elegans. PLOS ONE 2022, 17 (5) , e0267698. https://doi.org/10.1371/journal.pone.0267698
    58. Yu-Chia Chuang, Chih-Cheng Chen. Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels. Frontiers in Cell and Developmental Biology 2022, 10 https://doi.org/10.3389/fcell.2022.886048
    59. Aditya Vasan, Florian Allein, Marc Duque, Uri Magaram, Nicholas Boechler, Sreekanth H. Chalasani, James Friend. Microscale Concert Hall Acoustics to Produce Uniform Ultrasound Stimulation for Targeted Sonogenetics in hsTRPA1‐Transfected Cells. Advanced NanoBiomed Research 2022, 2 (5) https://doi.org/10.1002/anbr.202100135
    60. Sha-sha Yi, Jun-jie Zou, Long Meng, Hou-minji Chen, Zhong-qiu Hong, Xiu-fang Liu, Umar Farooq, Mo-xian Chen, Zheng-rong Lin, Wei Zhou, Li-juan Ao, Xi-quan Hu, Li-li Niu. Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice. Frontiers in Psychiatry 2022, 13 https://doi.org/10.3389/fpsyt.2022.864481
    61. Bolin Wang, Benjamin J. Lane, Charalampos Kapsalis, James R. Ault, Frank Sobott, Hassane El Mkami, Antonio N. Calabrese, Antreas C. Kalli, Christos Pliotas. Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state. Structure 2022, 30 (4) , 608-622.e5. https://doi.org/10.1016/j.str.2021.12.004
    62. Tamas Papp, Zsuzsanna Ferenczi, Bernadette Szilagyi, Matyas Petro, Angelika Varga, Eva Kókai, Ervin Berenyi, Gabor Olah, Gabor Halmos, Peter Szucs, Zoltan Meszar. Ultrasound Used for Diagnostic Imaging Facilitates Dendritic Branching of Developing Neurons in the Mouse Cortex. Frontiers in Neuroscience 2022, 16 https://doi.org/10.3389/fnins.2022.803356
    63. Kaifei Chen, Seyed Hesam Mousavi, Ranjeet Singh, Randall Q. Snurr, Gang Li, Paul A. Webley. Gating effect for gas adsorption in microporous materials—mechanisms and applications. Chemical Society Reviews 2022, 51 (3) , 1139-1166. https://doi.org/10.1039/D1CS00822F
    64. Yue Song, Jifan Chen, Cong Zhang, Lei Xin, Qunying Li, Yajing Liu, Chao Zhang, Shiyan Li, Pintong Huang. Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles. iScience 2022, 25 (2) , 103733. https://doi.org/10.1016/j.isci.2022.103733
    65. Wei Zhou, Xinhui Wang, Kaiyue Wang, Umar Farooq, Lijun Kang, Lili Niu, Long Meng. Ultrasound Activation of Mechanosensory Ion Channels in Caenorhabditis Elegans. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2022, 69 (2) , 473-479. https://doi.org/10.1109/TUFFC.2021.3120750
    66. Jiaru He, Junwei Wu, Yiyue Zhu, Yan Chen, Maodan Yuan, Lvming Zeng, Xuanrong Ji. Multitarget Transcranial Ultrasound Therapy in Small Animals Based on Phase-Only Acoustic Holographic Lens. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2022, 69 (2) , 662-671. https://doi.org/10.1109/TUFFC.2021.3131752
    67. Xiaodong Liu, Fang Qiu, Lijuan Hou, Xiaohui Wang. Review of Noninvasive or Minimally Invasive Deep Brain Stimulation. Frontiers in Behavioral Neuroscience 2022, 15 https://doi.org/10.3389/fnbeh.2021.820017
    68. Matthieu Provansal, Katia Marazova, José Alain Sahel, Serge Picaud. Vision Restoration by Optogenetic Therapy and Developments Toward Sonogenetic Therapy. Translational Vision Science & Technology 2022, 11 (1) , 18. https://doi.org/10.1167/tvst.11.1.18
    69. Zongyue Cheng, Chenmao Wang, Bowen Wei, Wenbiao Gan, Qifa Zhou, Meng Cui. High resolution ultrasonic neural modulation observed via in vivo two-photon calcium imaging. Brain Stimulation 2022, 15 (1) , 190-196. https://doi.org/10.1016/j.brs.2021.12.005
    70. Na Pang, Wen Meng, Yongsheng Zhong, Xiufang Liu, Zhengrong Lin, Tianxu Guo, Hui Zhou, Lin Qi, Long Meng, Lisheng Xu, Lili Niu. Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2022, 30 , 1851-1857. https://doi.org/10.1109/TNSRE.2022.3188516
    71. 铁琳 郝. Mechanosensitive Ion Channels and Neuromodulation. Advances in Clinical Medicine 2022, 12 (09) , 8678-8685. https://doi.org/10.12677/ACM.2022.1291253
    72. Haiming Fan. Central Nervous System Nanotechnology. 2022, 1-38. https://doi.org/10.1007/978-981-13-9374-7_29-1
    73. Andrew T. Krasley, Chandima Bulumulla, Abraham G. Beyene. Engineered Materials for Probing and Perturbing Brain Chemistry. 2022, 89-168. https://doi.org/10.1007/978-3-031-11409-0_3
    74. Aditya Vasan, Jeremy Orosco, Uri Magaram, Marc Duque, Connor Weiss, Yusuf Tufail, Sreekanth H Chalasani, James Friend. Ultrasound Mediated Cellular Deflection Results in Cellular Depolarization. Advanced Science 2022, 9 (2) https://doi.org/10.1002/advs.202101950
    75. Xuejun Qian, Gengxi Lu, Biju B. Thomas, Runze Li, Xiaoyang Chen, K. Kirk Shung, Mark Humayun, Qifa Zhou. Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution. BME Frontiers 2022, 2022 https://doi.org/10.34133/2022/9829316
    76. Kalyan Immadisetty, Adithya Polasa, Reid Shelton, Mahmoud Moradi. Elucidating the molecular basis of spontaneous activation in an engineered mechanosensitive channel. Computational and Structural Biotechnology Journal 2022, 20 , 2539-2550. https://doi.org/10.1016/j.csbj.2022.05.022
    77. Yuhao Chen, Yue Li, Meng Du, Jinsui Yu, Fei Gao, Zhen Yuan, Zhiyi Chen. Ultrasound Neuromodulation: Integrating Medicine and Engineering for Neurological Disease Treatment. BIO Integration 2021, 2 (4) , 169-179. https://doi.org/10.15212/bioi-2020-0026
    78. Bineet Sharma, Hossein Moghimianavval, Sung-Won Hwang, Allen P. Liu. Synthetic Cell as a Platform for Understanding Membrane-Membrane Interactions. Membranes 2021, 11 (12) , 912. https://doi.org/10.3390/membranes11120912
    79. Xingran Wang, Jiaqing Yan, Huiran Zhang, Yi Yuan. Ultrasonic thalamic stimulation modulates neural activity of thalamus and motor cortex in the mouse. Journal of Neural Engineering 2021, 18 (6) , 066037. https://doi.org/10.1088/1741-2552/ac409f
    80. Kai Yu, Xiaodan Niu, Esther Krook-Magnuson, Bin He. Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation. Nature Communications 2021, 12 (1) https://doi.org/10.1038/s41467-021-22743-7
    81. Linli Shi, Ying Jiang, Fernando R. Fernandez, Guo Chen, Lu Lan, Heng-Ye Man, John A. White, Ji-Xin Cheng, Chen Yang. Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter. Light: Science & Applications 2021, 10 (1) https://doi.org/10.1038/s41377-021-00580-z
    82. Boao Xia, Charles Sebesta, Sangsin Lee, Vishnu Nair, Xuan Zhao, Samantha Coffler, Jacob T Robinson, Jerzy O Szablowski. Biohybrid approaches to interface with the nervous system: the best of both worlds. Current Opinion in Biotechnology 2021, 72 , 86-94. https://doi.org/10.1016/j.copbio.2021.10.009
    83. Xue Xia, Anton Fomenko, Jean-François Nankoo, Ke Zeng, Yanqiu Wang, Jian Zhang, Andres M Lozano, Robert Chen. Time course of the effects of low-intensity transcranial ultrasound on the excitability of ipsilateral and contralateral human primary motor cortex. NeuroImage 2021, 243 , 118557. https://doi.org/10.1016/j.neuroimage.2021.118557
    84. Xingran Wang, Yiyao Zhang, Kaiqing Zhang, Yi Yuan. Influence of behavioral state on the neuromodulatory effect of low-intensity transcranial ultrasound stimulation on hippocampal CA1 in mouse. NeuroImage 2021, 241 , 118441. https://doi.org/10.1016/j.neuroimage.2021.118441
    85. Umar Farooq, Yuanting Liu, Pengqi Li, Zhiting Deng, Xiufang Liu, Wei Zhou, Shasha Yi, Ning Rong, Long Meng, Lili Niu, Hairong Zheng. Acoustofluidic dynamic interfacial tensiometry. The Journal of the Acoustical Society of America 2021, 150 (5) , 3608-3617. https://doi.org/10.1121/10.0007161
    86. Xuandi Hou, Zhihai Qiu, Quanxiang Xian, Shashwati Kala, Jianing Jing, Kin Fung Wong, Jiejun Zhu, Jinghui Guo, Ting Zhu, Minyi Yang, Lei Sun. Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Advanced Science 2021, 8 (21) https://doi.org/10.1002/advs.202101934
    87. Songfang Wu, Hong Li, Dongqi Wang, Luming Zhao, Xin Qiao, Xiao Zhang, Wei Liu, Changyong Wang, Jin Zhou. Genetically magnetic control of neural system via TRPV4 activation with magnetic nanoparticles. Nano Today 2021, 39 , 101187. https://doi.org/10.1016/j.nantod.2021.101187
    88. Yongsheng Zhong, Yibo Wang, Zhuoyi He, Zhengrong Lin, Na Pang, Lili Niu, Yanwu Guo, Min Pan, Long Meng. Closed-loop wearable ultrasound deep brain stimulation system based on EEG in mice. Journal of Neural Engineering 2021, 18 (4) , 0460e8. https://doi.org/10.1088/1741-2552/ac1d5c
    89. Louise M. Steele, Troy J. Kotsch, Catherine A. Legge, Delores J. Smith. Establishing C. elegans as a Model for Studying the Bioeffects of Therapeutic Ultrasound. Ultrasound in Medicine & Biology 2021, 47 (8) , 2346-2359. https://doi.org/10.1016/j.ultrasmedbio.2021.04.005
    90. Nannan Bian, Yi Yuan, Yingwei Li, Mengyang Liu, Xiaoli Li. Low-Intensity Pulsed Ultrasound Stimulation Inhibits Cortical Spreading Depression. Cerebral Cortex 2021, 31 (8) , 3872-3880. https://doi.org/10.1093/cercor/bhab055
    91. Yaoheng Yang, Christopher Pham Pacia, Dezhuang Ye, Lifei Zhu, Hongchae Baek, Yimei Yue, Jinyun Yuan, Mark J. Miller, Jianmin Cui, Joseph P. Culver, Michael R. Bruchas, Hong Chen. Sonothermogenetics for noninvasive and cell-type specific deep brain neuromodulation. Brain Stimulation 2021, 14 (4) , 790-800. https://doi.org/10.1016/j.brs.2021.04.021
    92. Pengkun Zhao, Shuaidong Huo, Jilin Fan, Junlin Chen, Fabian Kiessling, Arnold J. Boersma, Robert Göstl, Andreas Herrmann. Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound. Angewandte Chemie International Edition 2021, 60 (26) , 14707-14714. https://doi.org/10.1002/anie.202105404
    93. Pengkun Zhao, Shuaidong Huo, Jilin Fan, Junlin Chen, Fabian Kiessling, Arnold J. Boersma, Robert Göstl, Andreas Herrmann. Aktivierung der katalytischen Aktivität von Thrombin für die Bildung von Fibrin durch Ultraschall. Angewandte Chemie 2021, 133 (26) , 14829-14836. https://doi.org/10.1002/ange.202105404
    94. Quanxiang Xian, Zhihai Qiu, Shashwati Kala, Kin Fung Wong, Jinghui Guo, Lei Sun. Behavioral and Functional Assessment of Ultrasound Neuromodulation on Caenorhabditis Elegans. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2021, 68 (6) , 2150-2154. https://doi.org/10.1109/TUFFC.2021.3057873
    95. Xingyi Wan, Zhirong Liu, Linlin Li. Manipulation of Stem Cells Fates: The Master and Multifaceted Roles of Biophysical Cues of Biomaterials. Advanced Functional Materials 2021, 31 (23) https://doi.org/10.1002/adfm.202010626
    96. Shan He, Zefang Wang, Wei Pang, Chang Liu, Miaosen Zhang, Yang Yang, Xuexin Duan, Yanyan Wang. Ultra-rapid modulation of neurite outgrowth in a gigahertz acoustic streaming system. Lab on a Chip 2021, 21 (10) , 1948-1955. https://doi.org/10.1039/D0LC01262A
    97. Zhengrong Lin, Tianyuan Bian, Wei Zhou, Yibo Wang, Xiaowei Huang, Junjie Zou, Hui Zhou, Lili Niu, Jie Tang, Long Meng. Modulation of Neuronal Excitability by Low- Intensity Ultrasound in Two Principal Neurons of Rat Anteroventral Cochlear Nucleus. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2021, 68 (5) , 1752-1761. https://doi.org/10.1109/TUFFC.2021.3052203
    98. Xiuying Li, Hejian Xiong, Nicholas Rommelfanger, Xueqi Xu, Jonghae Youn, Paul A. Slesinger, Guosong Hong, Zhenpeng Qin. Nanotransducers for wireless neuromodulation. Matter 2021, 4 (5) , 1484-1510. https://doi.org/10.1016/j.matt.2021.02.012
    99. Xiaofei Qi, Kexin Lyu, Long Meng, Cuixian Li, Hongzheng Zhang, Lili Niu, Zhengrong Lin, Hairong Zheng, Jie Tang, . Low-Intensity Ultrasound Causes Direct Excitation of Auditory Cortical Neurons. Neural Plasticity 2021, 2021 , 1-10. https://doi.org/10.1155/2021/8855055
    100. Di Yuan, Haoyue Tian, Yulong Zhou, Jinjian Wu, Tong Sun, Zhuoni Xiao, Chunfeng Shang, Jiaojian Wang, Xin Chen, Yimin Sun, Joey Tang, Shijun Qiu, Li Hai Tan. Acupoint-brain (acubrain) mapping: Common and distinct cortical language regions activated by focused ultrasound stimulation on two language-relevant acupoints. Brain and Language 2021, 215 , 104920. https://doi.org/10.1016/j.bandl.2021.104920
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