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Persistent Luminescent Nanoparticles Containing Hydrogels for Targeted, Sustained, and Autofluorescence-Free Tumor Metastasis Imaging

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    Persistent Luminescent Nanoparticles Containing Hydrogels for Targeted, Sustained, and Autofluorescence-Free Tumor Metastasis Imaging
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    • Huaixin Zhao
      Huaixin Zhao
      Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China
      More by Huaixin Zhao
    • Chunxia Liu
      Chunxia Liu
      Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China
      More by Chunxia Liu
    • Zi Gu
      Zi Gu
      School of Chemical Engineering and Australian Centre for NanoMedicine, University of New South Wales, Sydney, NSW 2052, Australia
      More by Zi Gu
      Orcidhttp://orcid.org/0000-0002-7153-6596
    • Luxi Dong
      Luxi Dong
      State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300350, P. R. China
      More by Luxi Dong
    • Feng Li
      Feng Li
      Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China
      More by Feng Li
    • Chi Yao
      Chi Yao
      Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China
      More by Chi Yao
    • Dayong Yang*
      Dayong Yang
      Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China
      *E-mail: [email protected]
      More by Dayong Yang
      Orcidhttp://orcid.org/0000-0002-2634-9281
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    Nano Letters

    Cite this: Nano Lett. 2020, 20, 1, 252–260
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    https://doi.org/10.1021/acs.nanolett.9b03755
    Published December 2, 2019
    Copyright © 2019 American Chemical Society
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    Abstract

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    Metastasis is the primary cause of cancer morbidity and mortality. To obtain an effective diagnosis and treatment, precise imaging of tumor metastasis is required. Here we prepared persistent luminescent nanoparticles (PLNPs) containing a hydrogel (PL-gel) for targeted, sustained, and autofluorescence-free tumor metastasis imaging. PLNPs offered renewable long-lasting near-infrared (NIR) emitting without in situ radiation, favoring deep tissue penetration imaging without background interference. PLNPs were conjugated with 4-carboxyphenyl boronic acid (CPBA) to yield PLNPs-CPBA, which specifically recognized metastatic breast cancer cells (MBA-MD-231 cells) and enabled receptor-mediated endocytosis for specific cancer cell labeling. The PLNPs-CPBA-labeled cancer cells enabled sensitive imaging performance and high viability without influencing the migration and invasiveness of cancer cells for long-term tracking. PLNPs-CPBA were further encapsulated inside alginate to generate PL-gel for sustained PLNPs-CPBA release and tumor cell labeling, and the PL-gel showed enhanced renewable persistent luminescence compared to the PLNPs-CPBA suspension. The metastasis in the mouse breast cancer model was continuously tracked by persistent luminescence imaging, showing that PL-gel achieved noninvasive and highly selective imaging of tumor metastasis without background interference. Our PL-gel could be rationally designed to specifically target other types of cancer cells and thus provide a powerful and generic platform for the study of tumor metastasis.

    Copyright © 2019 American Chemical Society

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    Cite this: Nano Lett. 2020, 20, 1, 252–260
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    https://doi.org/10.1021/acs.nanolett.9b03755
    Published December 2, 2019
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