Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling SequenceClick to copy article linkArticle link copied!
- Dominik PolterauerDominik PolterauerCenter for Continuous Flow Synthesis and Processing, Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, A-8010 Graz, AustriaInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, A-8010 Graz, AustriaMore by Dominik Polterauer
- Kevin M. P. van EetenKevin M. P. van EetenFlowid B.V., Valeton 2A, 5301 LW Zaltbommel, The NetherlandsMore by Kevin M. P. van Eeten
- Wouter Stam
- Christopher A. Hone*Christopher A. Hone*Email: [email protected]Center for Continuous Flow Synthesis and Processing, Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, A-8010 Graz, AustriaInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, A-8010 Graz, AustriaMore by Christopher A. Hone
- C. Oliver Kappe*C. Oliver Kappe*Email: [email protected]Center for Continuous Flow Synthesis and Processing, Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, A-8010 Graz, AustriaInstitute of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, A-8010 Graz, AustriaMore by C. Oliver Kappe
Abstract
Solid-forming reactions are notoriously challenging to process in standard flow processes. Even though the formation of a solid product within a reaction can facilitate simple purification, homogeneous reactions are often utilized to enable flow processing. We report the application of dynamic spinning disc reactor (SDR) technology as a strategy to handle in situ solid product formation while handling exothermic chemistry. The system is exemplified by using a diazotization and azo coupling reaction system. Advantages of the approach include the use of water as the sole reaction solvent, mild operating conditions (20 °C), and a simple isolation procedure by filtration and drying. We demonstrate that stable operation of the system is possible for 120 min, affording 55.9 g of Sudan II.
Cited By
This article is cited by 3 publications.
- Arnab Chaudhuri, Wouter F.C. de Groot, Jasper H.A. Schuurmans, Stefan D.A. Zondag, Alessia Bianchi, Koen P.L. Kuijpers, Rémy Broersma, Amin Delparish, Matthieu Dorbec, John van der Schaaf, Timothy Noël. Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source. Organic Process Research & Development 2025, Article ASAP.
- Arnab Chaudhuri, John van der Schaaf. Intensified reactors for a paradigm shift in chemical processing: the case for spinning disc reactors. Current Opinion in Chemical Engineering 2024, 46 , 101052. https://doi.org/10.1016/j.coche.2024.101052
- Jihong Ouyang, Wenbo Yang, Zhaoyan Guo, Fujun Li, Wendong Liu, Pengfei Guo, Yumeng Zhou, Dali Gao, Lijing Zhang, Shengyang Tao. Modular Cascade of Flow Reactors: Continuous Flow Synthesis of Water‐Insoluble Diazo Dyes in Aqueous System. ChemSusChem 2024, 23 https://doi.org/10.1002/cssc.202400413
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.