Insights into Large-Scale Synthesis of BenfotiamineClick to copy article linkArticle link copied!
- Anamaria HanganuAnamaria HanganuResearch Centre of Applied Organic Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, Romania“C. D. Nenitzescu” Institute of Organic and Supramolecular Chemistry of the Romanian Academy, 202B Spl. Independentei, 060023 Bucharest, RomaniaMore by Anamaria Hanganu
- Maxim MaximovMaxim MaximovSC Microsin SRL, Pericle Papahagi Street 51–63, 032364 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, Gh Polizu Street 1–7, 011061 Bucharest, RomaniaMore by Maxim Maximov
- Oana-Cristina MaximovOana-Cristina MaximovSC Microsin SRL, Pericle Papahagi Street 51–63, 032364 Bucharest, RomaniaMore by Oana-Cristina Maximov
- Codruta C. PopescuCodruta C. PopescuResearch Centre of Applied Organic Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, RomaniaDepartment of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, RomaniaMore by Codruta C. Popescu
- Nicoleta SanduNicoleta SanduResearch Centre of Applied Organic Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, RomaniaMore by Nicoleta Sandu
- Mihaela FloreaMihaela FloreaResearch Centre of Applied Organic Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, RomaniaNational Institute of Material Physics, 405A Atomistilor Street, 077125 Magurele, RomaniaMore by Mihaela Florea
- Anca G. MireaAnca G. MireaNational Institute of Material Physics, 405A Atomistilor Street, 077125 Magurele, RomaniaMore by Anca G. Mirea
- Cristian GârbeaCristian GârbeaSC Microsin SRL, Pericle Papahagi Street 51–63, 032364 Bucharest, RomaniaMore by Cristian Gârbea
- Mihaela Matache*Mihaela Matache*Email: [email protected]Research Centre of Applied Organic Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, RomaniaDepartment of Inorganic and Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, RomaniaMore by Mihaela Matache
- Daniel P. Funeriu*Daniel P. Funeriu*Email: [email protected]Research Centre of Applied Organic Chemistry, University of Bucharest, 90 Panduri Street, RO-050663 Bucharest, RomaniaMore by Daniel P. Funeriu
Abstract
There has been increased interest in the synthesis of benfotiamine during the past few years, most likely as a direct consequence of growing market demand. It has much higher bioavailability than thiamine (vitamin B1) and therefore is more suitable for therapeutic purposes, especially in oral form. We report herein our research in an academic-private R&D project in which we investigate all aspects of the process on small and large scales. The procedure involves two labor-intensive steps, starting from thiami3ne chloride hydrochloride with the key intermediate thiamine monophosphate phosphate (TMP─the phosphate ester of thiamine monophosphate). We obtained the crystalline form of benfotiamine directly from the synthesis in the crystalline form required on the market, as proven by XRD powder spectroscopy, IR, and RAMAN.
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