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Controlled Flow Precipitation as a Valuable Tool for Synthesis

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† Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
‡ Department of Pharmaceutical Science, University of Perugia, Via del Liceo, 1, I-06123 Perugia, Italy
*E-mail: [email protected]
Cite this: Org. Process Res. Dev. 2016, 20, 2, 371–375
Publication Date (Web):November 17, 2015
https://doi.org/10.1021/acs.oprd.5b00331
Copyright © 2015 American Chemical Society
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    Abstract

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    In most standard flow process, the formation of solids represents a major problem often leading to obstruction of the flow device and reactor shutdown. However, many reactions produce solid products, and therefore finding ways to process these materials is an important area of research. In this article we demonstrate how a dynamically agitated flow reactor can be a powerful tool to facilitate workup and processing of biphasic solid–liquid flow streams at scale.

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