Electrosynthesis of Stabilized Diazo Compounds from Hydrazones
- Nour TanbouzaNour TanbouzaDépartement de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC G1V 0A6, CanadaMore by Nour Tanbouza
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- Alessia PettiAlessia PettiDepartment of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, U.K.More by Alessia Petti
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- Matthew C. LeechMatthew C. LeechDepartment of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, U.K.More by Matthew C. Leech
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- Laurent CaronLaurent CaronDépartement de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC G1V 0A6, CanadaMore by Laurent Caron
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- Jamie M. WalshJamie M. WalshDepartment of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, U.K.More by Jamie M. Walsh
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- Kevin Lam*Kevin Lam*Email: [email protected]Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, U.K.More by Kevin Lam
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- Thierry Ollevier*Thierry Ollevier*Email: [email protected]Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC G1V 0A6, CanadaMore by Thierry Ollevier
Abstract
An electrochemical synthesis of diazo compounds from hydrazones in yields as high as 99% was performed. This method was elaborated as a useful synthetic method and demonstrated on various diazo compounds (24 examples). Apart from exhibiting an efficiency that matched that of commonly used harsh and toxic chemical oxidants, this reaction is practically simple to set up, requires mild conditions, and is highly electron efficient (3 F/mol).
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