How Fungi Biosynthesize 3-Nitropropanoic Acid: The Simplest yet Lethal MycotoxinClick to copy article linkArticle link copied!
- Colin W. JohnsonColin W. JohnsonDepartment of Chemistry, University of California, Los Angeles, California 90095, United StatesMore by Colin W. Johnson
- Masao Ohashi*Masao Ohashi*Email: [email protected]Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United StatesMore by Masao Ohashi
- Yi Tang*Yi Tang*Email: [email protected]Department of Chemistry and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United StatesMore by Yi Tang
Abstract
We uncovered the biosynthetic pathway of the lethal mycotoxin 3-nitropropanoic acid (3-NPA) from koji mold Aspergillus oryzae. The biosynthetic gene cluster (BGC) of 3-NPA, which encodes an amine oxidase and a decarboxylase, is conserved in many fungi used in food processing, although most of the strains have not been reported to produce 3-NPA. Our discovery will lead to efforts that improve the safety profiles of these indispensable microorganisms in making food, alcoholic beverages, and seasoning.
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This article is cited by 5 publications.
- Hua-Wei Lv, Jia-Gui Tang, Bin Wei, Meng-Di Zhu, Hua-Wei Zhang, Zhong-Bo Zhou, Bo-Yi Fan, Hong Wang, Xing-Nuo Li. Bioinformatics assisted construction of the link between biosynthetic gene clusters and secondary metabolites in fungi. Biotechnology Advances 2025, 81 , 108547. https://doi.org/10.1016/j.biotechadv.2025.108547
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- A. Morrie Craig, Linda L. Blythe, Peter S. Spencer. Mold Mycotoxins and Tremorgens. 2024https://doi.org/10.1016/B978-0-323-95702-1.00190-1
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