Catalytic Asymmetric Oxidative α-C–H N,O-Ketalization of Ketones by Chiral Primary AmineClick to copy article linkArticle link copied!
Abstract
A highly enantioselective primary amine catalyzed α,α-bis-functionalization of β-ketocarbonyls and cyclohexanones is described. This transformation employs N-hydroxycarbamates as both nitrogen and oxygen sources under aerobic oxidative conditions to furnish chiral N,O-ketals with high yields and enantioselectivities.
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