General Methodology for the Preparation of Unsymmetrical α-Linked Bisenones via Ligandless Cross-Coupling ReactionsClick to copy article linkArticle link copied!
Abstract
A stereocontrolled Stille cross-coupling reaction, involving the use of Pd2dba3, provides a general procedure for the synthesis of unsymmetrical α-linked bisenone systems. The transformation is achieved in the absence of phosphine ligands under conditions that promote the stabilization of “ligandless” palladium catalysis. The extension of these studies illustrates Suzuki–Miyaura reactions of 2-boryl-2-cyclohexen-1-one with iodide and triflate partners for the synthesis of novel electron-deficient 1,3-dienes.
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