DPPF-Catalyzed Atom-Transfer Radical Cyclization via Allylic RadicalClick to copy article linkArticle link copied!
- Longlei Hou
- Zhaozhao Zhou
- Dong Wang
- Yuwen Zhang
- Xin Chen
- Lijin Zhou
- Yang Hong
- Wei Liu
- Yading Hou
- Xiaofeng Tong
Abstract

A general iron-catalyzed strategy for the atom-transfer radical cyclization (ATRC) of allylic halide is reported. Critical to this strategy is the use of DPPF [1,1′-bis(diphenylphosphino)ferrocene] as catalyst, which allows for efficient generation of the allylic radical species via a single-electron transfer (SET) process. The feasibility of achieving ATRC reactions of propargyl chlorides is also demonstrated, which affords products with an exocyclic allene moiety.
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