Palladium-Catalyzed Cascade Arylation of Vinylogous Esters Enabled by Tris(1-adamantyl)phosphine
- Yi-Chi YangYi-Chi YangDepartment of Applied Chemistry, National Chiao Tung University, 1001 University Road, Hsinchu 30010, TaiwanMore by Yi-Chi Yang
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- Yi-Ching LinYi-Ching LinDepartment of Applied Chemistry, National Chiao Tung University, 1001 University Road, Hsinchu 30010, TaiwanMore by Yi-Ching Lin
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- Yen-Ku Wu*Yen-Ku Wu*E-mail: [email protected]Department of Applied Chemistry, National Chiao Tung University, 1001 University Road, Hsinchu 30010, TaiwanMore by Yen-Ku Wu
Abstract
Described is a method for the transformation of a cyclic vinylogous ester to the corresponding polyarylated product. We found a catalytic system comprising palladium diacetate and tris(1-adamantyl)phosphine is quite effective in promoting a set of controlled cascade arylations. As a result, a range of novel (hetero)aryl-containing scaffolds was synthesized with a high level of efficiency.
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