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Toward Controlled Electrical Stimulation for Wound Healing Based on a Precision Layered Skin Model
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    Toward Controlled Electrical Stimulation for Wound Healing Based on a Precision Layered Skin Model
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    • Menglu Li
      Menglu Li
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Menglu Li
    • Xiaofeng Wang
      Xiaofeng Wang
      Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province PR China
    • Pandey Rajagopalan
      Pandey Rajagopalan
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
    • Liang Zhang
      Liang Zhang
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Liang Zhang
    • Shijie Zhan
      Shijie Zhan
      Department of Engineering, University of Cambridge, Cambridge CB3 0FA, United Kingdom
      More by Shijie Zhan
    • Shuyi Huang
      Shuyi Huang
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Shuyi Huang
    • Wei Li
      Wei Li
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Wei Li
    • Xiangyu Zeng
      Xiangyu Zeng
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Xiangyu Zeng
    • Qikai Ye
      Qikai Ye
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Qikai Ye
    • Yulu Liu
      Yulu Liu
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Yulu Liu
    • Kai Zhong
      Kai Zhong
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Kai Zhong
    • Jong Min Kim
      Jong Min Kim
      Department of Engineering, University of Cambridge, Cambridge CB3 0FA, United Kingdom
      More by Jong Min Kim
    • Jikui Luo
      Jikui Luo
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Jikui Luo
    • Shurong Dong
      Shurong Dong
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      More by Shurong Dong
    • Rongcheng Gu
      Rongcheng Gu
      Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United States
      More by Rongcheng Gu
    • Xiaozhi Wang*
      Xiaozhi Wang
      Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, China
      Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, China
      *Email: [email protected]
      More by Xiaozhi Wang
    • Wei-Qiang Tan*
      Wei-Qiang Tan
      Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province PR China
      *Email: [email protected]
    Other Access OptionsSupporting Information (1)

    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2020, 3, 12, 8901–8910
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsabm.0c01190
    Published November 16, 2020
    Copyright © 2020 American Chemical Society

    Abstract

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    Bioelectricity performs vital functions in the human body. When skin is damaged, the endogenous electric field will orient toward the center of wounds, guiding the migration of relevant cells and stimulating the secretion of growth factors. A large number of experiments have indicated that external electric stimuli have significant positive influences on wound healing. However, the mechanism of this therapy remains unclear, and the current selection of parameters for electric stimuli tends to be arbitrary or empirical, making it inefficient and ineffective. From the perspective of bioelectricity and electrochemistry, the mechanism of electric stimuli is investigated in detail based on a sectioned multilayer model in this work, and an electric stimuli window is obtained in terms of frequency, duty cycle, voltage, and electric charge and verified experimentally. This model provides general guidance for the optimization of electrical stimuli therapy for wound healing.

    Copyright © 2020 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsabm.0c01190.

    • Images of the AC impedance measurement platform (CHI660); the homemade test fixture; platform of the epidermis, dermis, and musculoaponeurotic layer; thickness and area of skin samples; results of COMSOL simulation; calculation of CPE element; analysis of voltage distribution (PDF)

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    Cited By

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    This article is cited by 21 publications.

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    18. Abraham E Wolf, Matthew A Heinrich, Isaac B Breinyn, Tom J Zajdel, Daniel J Cohen, . Short-term bioelectric stimulation of collective cell migration in tissues reprograms long-term supracellular dynamics. PNAS Nexus 2022, 1 (1) https://doi.org/10.1093/pnasnexus/pgac002
    19. Tom J. Zajdel, Gawoon Shim, Daniel J. Cohen. Come together: On-chip bioelectric wound closure. Biosensors and Bioelectronics 2021, 192 , 113479. https://doi.org/10.1016/j.bios.2021.113479
    20. Yt Jun Cheah, Muhamad Ramdzan Buyong, Mohd Heikal Mohd Yunus. Wound Healing with Electrical Stimulation Technologies: A Review. Polymers 2021, 13 (21) , 3790. https://doi.org/10.3390/polym13213790
    21. Xiao Xiao, Xiao Xiao, Ardo Nashalian, Alberto Libanori, Yunsheng Fang, Xiyao Li, Jun Chen. Triboelectric Nanogenerators for Self‐Powered Wound Healing. Advanced Healthcare Materials 2021, 10 (20) https://doi.org/10.1002/adhm.202100975
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    23. Gawoon Shim, Danelle Devenport, Daniel J. Cohen. Cellular crowd control: overriding endogenous cell coordination makes cell migration more susceptible to external programming. 2021https://doi.org/10.1101/2021.01.23.427700
    24. Tom J. Zajdel, Gawoon Shim, Daniel J. Cohen. Come together: bioelectric healing-on-a-chip. 2020https://doi.org/10.1101/2020.12.29.424578

    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2020, 3, 12, 8901–8910
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsabm.0c01190
    Published November 16, 2020
    Copyright © 2020 American Chemical Society

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