Toward Controlled Electrical Stimulation for Wound Healing Based on a Precision Layered Skin ModelClick to copy article linkArticle link copied!
- Menglu LiMenglu LiKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Menglu Li
- Xiaofeng WangXiaofeng WangDepartment of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province PR ChinaMore by Xiaofeng Wang
- Pandey RajagopalanPandey RajagopalanKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Pandey Rajagopalan
- Liang ZhangLiang ZhangKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Liang Zhang
- Shijie ZhanShijie ZhanDepartment of Engineering, University of Cambridge, Cambridge CB3 0FA, United KingdomMore by Shijie Zhan
- Shuyi HuangShuyi HuangKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Shuyi Huang
- Wei LiWei LiKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Wei Li
- Xiangyu ZengXiangyu ZengKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Xiangyu Zeng
- Qikai YeQikai YeKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Qikai Ye
- Yulu LiuYulu LiuKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Yulu Liu
- Kai ZhongKai ZhongKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Kai Zhong
- Jong Min KimJong Min KimDepartment of Engineering, University of Cambridge, Cambridge CB3 0FA, United KingdomMore by Jong Min Kim
- Jikui LuoJikui LuoKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Jikui Luo
- Shurong DongShurong DongKey Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Shurong Dong
- Rongcheng GuRongcheng GuDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United StatesMore by Rongcheng Gu
- Xiaozhi Wang*Xiaozhi Wang*Email: [email protected]Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang, College of ISEE, Zhejiang University, Hangzhou 310027, ChinaHangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310018, ChinaMore by Xiaozhi Wang
- Wei-Qiang Tan*Wei-Qiang Tan*Email: [email protected]Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province PR ChinaMore by Wei-Qiang Tan
Abstract

Bioelectricity performs vital functions in the human body. When skin is damaged, the endogenous electric field will orient toward the center of wounds, guiding the migration of relevant cells and stimulating the secretion of growth factors. A large number of experiments have indicated that external electric stimuli have significant positive influences on wound healing. However, the mechanism of this therapy remains unclear, and the current selection of parameters for electric stimuli tends to be arbitrary or empirical, making it inefficient and ineffective. From the perspective of bioelectricity and electrochemistry, the mechanism of electric stimuli is investigated in detail based on a sectioned multilayer model in this work, and an electric stimuli window is obtained in terms of frequency, duty cycle, voltage, and electric charge and verified experimentally. This model provides general guidance for the optimization of electrical stimuli therapy for wound healing.
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(42)
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(9)
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(1)
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(1)
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2
S
3
/TiO
2
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(7)
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(1)
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(21)
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(29)
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