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    Combining Nanoparticle Shape Modulation and Polymersome Technology in Drug Delivery
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    • Cara Katterman
      Cara Katterman
      Department of Biological Sciences, Clemson University, Clemson, South Carolina 29634, United States
      More by Cara Katterman
    • Christopher Pierce
      Christopher Pierce
      Department of Chemical and Biomolecular Engineering, Clemson University, Clemson, South Carolina 29634, United States
      More by Christopher Pierce
    • Jessica Larsen*
      Jessica Larsen
      Department of Chemical and Biomolecular Engineering  and  Department of Bioengineering, Clemson University, Clemson, South Carolina 29634, United States
      *Email: [email protected]
      More by Jessica Larsen
      Orcidhttp://orcid.org/0000-0003-2756-9523
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    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2021, 4, 4, 2853–2862
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    https://doi.org/10.1021/acsabm.1c00203
    Published March 8, 2021
    Copyright © 2021 American Chemical Society
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    Abstract

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    This paper highlights the potential benefits of using self-assembled polymeric nanoparticles of various shapes to enhance drug uptake. First, we highlight the growth and development of the polymersome, using a liposome as a blueprint for amphiphilic codelivery. Then, we focus on the advantages of nanoparticle elongation, drawing from the field of solid nanoparticles, as opposed to self-assembled vesicles which have not yet been extensively explored in shape-modulated drug delivery applications. Notably, regardless of the material used in the solid nanoparticle systems, more elongated shapes lead to greater cellular uptake, decreased interaction with the reticuloendothelial system macrophages, and increased circulation times. Finally, we highlight the methods currently being developed to modulate polymersome shape, thus providing a drug delivery system with the benefits derived from amphiphilicity and elongated structures. Current methods employed to modulate polymersome shape involve osmotic pressure gradients, solvent switching, and the use of cross-linking agents. Although these methods are successful in modulating polymersome shapes and the benefits of elongated nanoparticles in therapeutic targeting are clear, these methods have not yet been explored for applications in drug delivery.

    Copyright © 2021 American Chemical Society

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    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2021, 4, 4, 2853–2862
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsabm.1c00203
    Published March 8, 2021
    Copyright © 2021 American Chemical Society
    Request reuse permissions

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