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A Memristor Based on Organic Heterojunction for Monitoring Follicular Fluid within the Ovaries during Aging

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    A Memristor Based on Organic Heterojunction for Monitoring Follicular Fluid within the Ovaries during Aging
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    • Yu Cui
      Yu Cui
      Department of Reproductive Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
      Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      Interdisciplinary Research Center of Frontier Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      More by Yu Cui
    • Yanmin Ma
      Yanmin Ma
      Department of Reproductive Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
      More by Yanmin Ma
    • Bai Sun*
      Bai Sun
      Department of Reproductive Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
      Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      Interdisciplinary Research Center of Frontier Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      *Email: [email protected]
      More by Bai Sun
      Orcidhttps://orcid.org/0000-0002-5840-509X
    • Zelin Cao
      Zelin Cao
      Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      Interdisciplinary Research Center of Frontier Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      More by Zelin Cao
    • Kaikai Gao
      Kaikai Gao
      Frontier Institute of Science and Technology (FIST), Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      Interdisciplinary Research Center of Frontier Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China
      More by Kaikai Gao
    • Xiaorui Zhang
      Xiaorui Zhang
      Department of Reproductive Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
      More by Xiaorui Zhang
    • Yiqing Chen
      Yiqing Chen
      Department of Reproductive Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
      More by Yiqing Chen
    • Wenting Yang*
      Wenting Yang
      Department of Reproductive Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
      *Email: [email protected]
      More by Wenting Yang
      Orcidhttps://orcid.org/0009-0001-2611-4650
    • Guoqing Tong*
      Guoqing Tong
      Department of Reproductive Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
      *Email: [email protected]
      More by Guoqing Tong
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    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2025, XXXX, XXX, XXX-XXX
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    https://doi.org/10.1021/acsabm.5c00741
    Published June 4, 2025
    © 2025 American Chemical Society
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    Abstract

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    Memristor has shown significant application prospects in the post Moore’s electron era, but its application in the field of reproductive medicine is still blank. In this work, a memristor with Ag/C40H56-PEDOT:PSS/FTO structure was prepared by using a heterojunction of natural biomaterial carotene (C40H56) and Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as the functional layer of the device, which demonstrates remarkable resistance switching capabilities under a certain bias voltage. Subsequently, this memristor was employed to monitor the follicular fluid within the ovaries during aging, indicating that the device can be effectively employed to monitor the follicular fluid within the ovaries during the aging process and to conduct diagnoses by leveraging the correlation between H2O2 and oocyte aging. Furthermore, the results confirm the memristor can assist physicians in predicting ovarian function, oocyte quality and subsequent outcomes of embryos in vitro fertilization. Finally, through a meticulous analysis of the testing results, the working mechanisms and conductivity models of the device were comprehensively expounded upon by means of segmented fitting of experimental data. This research work demonstrates the efficacy of memristors in monitoring abnormal oocytes and embryonic outcomes, thereby laying a scientific foundation for the application of memristors in health monitoring and disease diagnosis.

    © 2025 American Chemical Society

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    ACS Applied Bio Materials

    Cite this: ACS Appl. Bio Mater. 2025, XXXX, XXX, XXX-XXX
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsabm.5c00741
    Published June 4, 2025
    © 2025 American Chemical Society
    Request reuse permissions

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