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Amino/Amido Conjugates Form to Nanoscale Cobalt Physiometacomposite (PMC) Materials Functionally Delivering Nucleic Acid Therapeutic to Nucleus Enhancing Anticancer Activity via Ras-Targeted Protein Interference

  • Robert K. DeLong*
    Robert K. DeLong
    Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States
    *E-mail: [email protected]. Phone: 785-532-6313.
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    Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri 63130, United States
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Cite this: ACS Appl. Bio Mater. 2020, 3, 1, 175–179
Publication Date (Web):January 2, 2020
https://doi.org/10.1021/acsabm.9b00798
Copyright © 2020 American Chemical Society

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    Abstract

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    Aberrant splicing and protein interaction of Ras binding domain (RBD) are associated with melanoma drug resistance. Here, cobalt or nickel doped zinc oxide (ZnO) physiometacomposite (PMC) materials bind to RNA and peptide shown by Ninhydrin staining, UV–vis, Fourier transform infrared, and circular dichroism spectroscopy. PMCs deliver splice switching oligomer (SSO) into melanoma cells or 3-D tumor spheroids shown by flow cytometry, fluorescence microscopy, and bioluminescence. Stability in serum, liver, or tumor homogenate up to 48 h and B16F10 melanoma inhibition ≥98–99% is shown. These data suggest preclinical potential of PMC for delivery of SSO, RBD, or other nucleic acid therapeutic and anticancer peptides.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsabm.9b00798.

    • CD spectroscopy; cytotoxicity assays; Ninhydrin test; SSO delivery and spheroid assay; microscopy; payload (PDF)

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    Cited By

    This article is cited by 5 publications.

    1. Robert K. DeLong, Hanah Huber, Cesar Aparicio-Lopez, Abeera Bhatti, Ryan Swanson, Tej B. Shrestha, Natasha N. Gaudreault. Enzyme Nanoscale Interactions with Manganese Zinc Sulfide Give Insight into Potential Antiviral Mechanisms and SARS-CoV-2 Inhibition. ACS Pharmacology & Translational Science 2022, 5 (7) , 449-457. https://doi.org/10.1021/acsptsci.2c00041
    2. Sagar Rayamajhi, Sarah Wilson, Santosh Aryal, Robert DeLong. Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity. Nanoscale Research Letters 2021, 16 (1) https://doi.org/10.1186/s11671-021-03626-8
    3. Mohadeseh Safaei, Masoud Reza Shishehbore. Energy conversion and optical applications of MXene quantum dots. Journal of Materials Science 2021, 56 (32) , 17942-17978. https://doi.org/10.1007/s10853-021-06428-6
    4. Hanah F. Huber, Majid Jaberi-Douraki, Sarah DeVader, Cesar Aparicio-Lopez, Juliet Nava-Chavez, Xuan Xu, Nuwan Indika Millagaha Gedara, Natasha N. Gaudreault, Robert K. Delong. Targeting SARS-CoV-2 Variants with Nucleic Acid Therapeutic Nanoparticle Conjugates. Pharmaceuticals 2021, 14 (10) , 1012. https://doi.org/10.3390/ph14101012
    5. Robert K DeLong, Ryan Swanson, Megan C Niederwerder, Pratiksha Khanal, Santosh Aryal, Ramesh Marasini, Majid Jaberi-Douraki, Heman Shakeri, Reza Mazloom, Sarah Schneider, Steve Ensley, Lane L Clarke, Rowena A Woode, Sarah Young, Sagar Rayamajhi, Tracy Miesner, Mary L Higginbotham, Zhoumeng Lin, Tej Shrestha, Kartik Ghosh, Garry Glaspell, Elza N Mathew. Zn-Based Physiometacomposite Nanoparticles: Distribution, Tolerance, Imaging, And Antiviral and Anticancer Activity. Nanomedicine 2021, 16 (21) , 1857-1872. https://doi.org/10.2217/nnm-2021-0179