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Decorating Nanostructured Surfaces with Antimicrobial Peptides to Efficiently Fight Bacteria

  • Serena Rigo
    Serena Rigo
    Department of Chemistry, University of Basel, Mattenstrasse 24a, BPR 1096, CH-4002 Basel, Switzerland
    More by Serena Rigo
  • Dimitri Hürlimann
    Dimitri Hürlimann
    Department of Chemistry, University of Basel, Mattenstrasse 24a, BPR 1096, CH-4002 Basel, Switzerland
  • Laurent Marot
    Laurent Marot
    Department of Physics, University of Basel, Klingelbergstrasse 82, CH-4056 Basel, Switzerland
  • Martin Malmsten
    Martin Malmsten
    Department of Pharmacy, University of Copenhagen, DK-2100 Copenhagen, Denmark
    Department of Physical Chemistry 1, Lund University, SE-221 00 Lund, Sweden
  • Wolfgang Meier
    Wolfgang Meier
    Department of Chemistry, University of Basel, Mattenstrasse 24a, BPR 1096, CH-4002 Basel, Switzerland
  • , and 
  • Cornelia G. Palivan*
    Cornelia G. Palivan
    Department of Chemistry, University of Basel, Mattenstrasse 24a, BPR 1096, CH-4002 Basel, Switzerland
    *Email. [email protected]
Cite this: ACS Appl. Bio Mater. 2020, 3, 3, 1533–1543
Publication Date (Web):February 6, 2020
https://doi.org/10.1021/acsabm.9b01154
Copyright © 2020 American Chemical Society
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Abstract

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With conventional antibiotic therapies being increasingly ineffective, bacterial infections with subsequent biofilm formation represent a global threat to human health. Here, an active and a passive strategy based on polymeric micelles were combined to fight bacterial growth. The passive strategy involved covalent immobilization of polymeric micelles through Michael addition between exposed maleimide and thiol functionalized surfaces. Compared to the bare surface, micelle-decorated surfaces showed reduced adherence and survival of bacteria. To extend this passive defense against bacteria with an active strategy, the immobilized micelles were equipped with the antimicrobial peptide KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYTLR). The peptide interacted nonspecifically with the immobilized micelles where it retained its antimicrobial property. The successful surface decoration with KYE28 was demonstrated by a combination of X-ray photoelectron spectroscopy and quartz crystal microbalance with dissipation monitoring. The initial antimicrobial activity of the nanostructured surfaces against Escherichia coli was found to be increased by the presence of KYE28. The combination of the active and passive strategy represents a straightforward modular approach that can easily be adapted, for example, by exchanging the antimicrobial peptide to optimize potency against challenging bacterial strains, and/or to simultaneously achieve antimicrobial and anti-infection properties.

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The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsabm.9b01154.

  • Additional materials, methods, and measurements; TEM micrographs, DLS measurements, and leakage experiments; Surface characterization with AFM images, ellipsometry, water contact angle, XPS, and QCM-D; Peptide synthesis, purification with HPLC, and characterization with mass spectrometry (PDF)

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Cited By

This article is cited by 13 publications.

  1. Bhuvaneshwari Balasubramaniam, Prateek, Sudhir Ranjan, Mohit Saraf, Prasenjit Kar, Surya Pratap Singh, Vijay Kumar Thakur, Anand Singh, Raju Kumar Gupta. Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics. ACS Pharmacology & Translational Science 2021, 4 (1) , 8-54. https://doi.org/10.1021/acsptsci.0c00174
  2. Babloo Sharma, Carlie M. Clem, Alda Diaz Perez, Susanne Striegler. Antimicrobial Activity of Microgels with an Immobilized Copper(II) Complex Linked to Cross-Linking and Composition. ACS Applied Bio Materials 2020, 3 (11) , 7611-7619. https://doi.org/10.1021/acsabm.0c00820
  3. Ye Gao, Avijit Pramanik, Shamily Patibandla, Kaelin Gates, Glake Hill, Andrew Ignatius, Paresh Chandra Ray. Development of Human Host Defense Antimicrobial Peptide-Conjugated Biochar Nanocomposites for Combating Broad-Spectrum Superbugs. ACS Applied Bio Materials 2020, 3 (11) , 7696-7705. https://doi.org/10.1021/acsabm.0c00880
  4. Kristina Y. Gudz, Elizaveta S. Permyakova, Andrei T. Matveev, Andrey V. Bondarev, Anton M. Manakhov, Daria A. Sidorenko, Svetlana Y. Filippovich, Anatoli V. Brouchkov, Dmitri V. Golberg, Sergei G. Ignatov, Dmitry V. Shtansky. Pristine and Antibiotic-Loaded Nanosheets/Nanoneedles-Based Boron Nitride Films as a Promising Platform to Suppress Bacterial and Fungal Infections. ACS Applied Materials & Interfaces 2020, 12 (38) , 42485-42498. https://doi.org/10.1021/acsami.0c10169
  5. Rituparna Saha, Debalina Bhattacharya, Mainak Mukhopadhyay. Advances in modified antimicrobial peptides as marine antifouling material. Colloids and Surfaces B: Biointerfaces 2022, 220 , 112900. https://doi.org/10.1016/j.colsurfb.2022.112900
  6. Jack A. Doolan, George T. Williams, Kira L. F. Hilton, Rajas Chaudhari, John S. Fossey, Benjamin T. Goult, Jennifer R. Hiscock. Advancements in antimicrobial nanoscale materials and self-assembling systems. Chemical Society Reviews 2022, 51 (20) , 8696-8755. https://doi.org/10.1039/D1CS00915J
  7. Viviana Maffeis, Dimitri Hürlimann, Agata Krywko‐Cendrowska, Cora‐Ann Schoenenberger, Catherine E. Housecroft, Cornelia G. Palivan. A DNA‐Micropatterned Surface for Propagating Biomolecular Signals by Positional on‐off Assembly of Catalytic Nanocompartments. Small 2022, 5 , 2202818. https://doi.org/10.1002/smll.202202818
  8. Mark Sheridan, Caitriona Winters, Fernanda Zamboni, Maurice N. Collins. Biomaterials: Antimicrobial surfaces in biomedical engineering and healthcare. Current Opinion in Biomedical Engineering 2022, 22 , 100373. https://doi.org/10.1016/j.cobme.2022.100373
  9. Caio H. N. Barros, Dishon W. Hiebner, Stephanie Fulaz, Stefania Vitale, Laura Quinn, Eoin Casey. Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity. Journal of Nanobiotechnology 2021, 19 (1) https://doi.org/10.1186/s12951-021-00851-2
  10. Yin Wang, Hui Sun. Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents. Pharmaceutics 2021, 13 (12) , 2108. https://doi.org/10.3390/pharmaceutics13122108
  11. Cheng Wang, Tingting Hong, Pengfei Cui, Jianhao Wang, Jiang Xia. Antimicrobial peptides towards clinical application: Delivery and formulation. Advanced Drug Delivery Reviews 2021, 175 , 113818. https://doi.org/10.1016/j.addr.2021.05.028
  12. Myrto Kyropoulou, Saziye Yorulmaz Avsar, Cora-Ann Schoenenberger, Cornelia G. Palivan, Wolfgang. P. Meier. From spherical compartments to polymer films: exploiting vesicle fusion to generate solid supported thin polymer membranes. Nanoscale 2021, 13 (14) , 6944-6952. https://doi.org/10.1039/D1NR01122G
  13. Pan Cao, Kewei Liu, Xiaodan Liu, Wei Sun, Duoli Wu, Chengqing Yuan, Xiuqin Bai, Chao Zhang. Antibacterial properties of Magainin II peptide onto 304 stainless steel surfaces: A comparison study of two dopamine modification methods. Colloids and Surfaces B: Biointerfaces 2020, 194 , 111198. https://doi.org/10.1016/j.colsurfb.2020.111198

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