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Intrafibrillar Mineralized Collagen–Hydroxyapatite-Based Scaffolds for Bone Regeneration

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    Research Article

    Intrafibrillar Mineralized Collagen–Hydroxyapatite-Based Scaffolds for Bone Regeneration
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    • Le Yu
      Le Yu
      Department of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut 06269, United States
      Department of Chemical and Biomolecular Engineering, Ohio University, Athens, Ohio 45701, United States
      More by Le Yu
      Orcidhttp://orcid.org/0000-0002-9545-7091
    • David W. Rowe
      David W. Rowe
      Center for Regenerative Medicine and Skeletal Development, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032, United States
      More by David W. Rowe
    • Inosh P. Perera
      Inosh P. Perera
      Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States
      More by Inosh P. Perera
    • Jiyao Zhang
      Jiyao Zhang
      Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States
      More by Jiyao Zhang
    • Steven L. Suib
      Steven L. Suib
      Institute of Materials Science  and  Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States
      More by Steven L. Suib
      Orcidhttp://orcid.org/0000-0003-3073-311X
    • Xiaonan Xin*
      Xiaonan Xin
      Center for Regenerative Medicine and Skeletal Development, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032, United States
      *Email: [email protected]. Tel: +1 (860)-679-3032.
      More by Xiaonan Xin
    • Mei Wei*
      Mei Wei
      Department of Materials Science and Engineering  and  Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States
      Department of Mechanical Engineering, Ohio University, Athens, Ohio 45701, United States
      *Email: [email protected]. Tel: +1 (740)-593-1474.
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    Cite this: ACS Appl. Mater. Interfaces 2020, 12, 16, 18235–18249
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    https://doi.org/10.1021/acsami.0c00275
    Published March 26, 2020
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    Abstract

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    As one of the major challenges in the field of tissue engineering, large skeletal defects have attracted wide attention from researchers. Collagen (Col) and hydroxyapatite (HA), the most abundant protein and the main component in natural bone, respectively, are usually used as a biomimetic composite material in tissue engineering due to their excellent biocompatibility and biodegradability. In this study, novel intrafibrillar mineralized Col–HA-based scaffolds, constructed in either cellular or lamellar microstructures, were established through a biomimetic method to enhance the new bone-regenerating capability of tissue engineering scaffolds. Moreover, iron (Fe) and manganese (Mn), two of the essential trace elements in the body, were successfully incorporated into the lamellar scaffold to further improve the osteoinductivity of these biomaterials. It was found that the lamellar scaffolds demonstrated better osteogenic abilities compared to both in-house and commercial Col–HA-based cellular scaffolds in vitro and in vivo. Meanwhile, Fe/Mn incorporation further amplified the osteogenic promotion of the lamellar scaffolds. More importantly, a synergistic effect was observed in the Fe and Mn dual-element-incorporated lamellar scaffolds for both in vitro osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and in vivo bone regeneration loaded with fresh bone marrow cells. This study provides a simple but practical strategy for the creation of functional scaffolds for bone regeneration.

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    • Photographs of collagen–hydroxyapatite hydrogels and TEM images (Figure S1); 1H NMR spectra of various lamellar scaffolds (Figure S2); representative images of fluorescent event distributions (Figure S3); total positive fluorescence (Figure S4); ion concentration of human blood plasma and m-SBF (Table S1); and concentration of essential cations in the m-SBF (Table S2) (PDF)

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    Cite this: ACS Appl. Mater. Interfaces 2020, 12, 16, 18235–18249
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