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    Biological and Medical Applications of Materials and Interfaces

    Metal–Organic Framework Microsphere Formulation for Pulmonary Administration
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2020, 12, 23, 25676–25682
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    https://doi.org/10.1021/acsami.0c07356
    Published May 4, 2020
    Copyright © 2020 American Chemical Society
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    Abstract

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    Although nanoscaled metal–organic frameworks (nanoMOFs) are promising drug carriers, their appropriate formulation remains almost unexplored and basically restricted to intravenous routes. Lungs, beneficiating from a large absorption surface and low enzymatic presence, are a very attractive target for both local and systemic delivery. However, pulmonary nanoMOF formulation is a pending and defying task. Thus, we propose a pioneer nanoMOF-based microsphere system as a potential platform for pulmonary administration. A biocompatible nanoMOF was successfully encapsulated in mannitol by a simple and continuous spray-drying technique. Upon intratracheal administration to rats, the resulting formulation, exhibiting optimal properties (i.e., homogeneity, size, density, and spray-drying process yield), was able to release the intact nanoMOF carrier uniformly along the lungs, reaching the bronchioles and alveoli.

    Copyright © 2020 American Chemical Society

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    • Synthetic methods, MS formulation details, characterization, colloidal stability studies, HPLC determinations, and in vivo distribution studies (PDF)

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    Cited By

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    This article is cited by 24 publications.

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2020, 12, 23, 25676–25682
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.0c07356
    Published May 4, 2020
    Copyright © 2020 American Chemical Society
    Request reuse permissions

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