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Polymer-Coated Cerium Oxide Nanoparticles as Oxidoreductase-like Catalysts

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    Applications of Polymer, Composite, and Coating Materials

    Polymer-Coated Cerium Oxide Nanoparticles as Oxidoreductase-like Catalysts
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    • Victor Baldim
      Victor Baldim
      Matière et systèmes complexes, Université de Paris, CNRS, 75013 Paris, France
      Electrochimie et Physicochimie aux Interfaces, Université de Versailles Saint-Quentin-en-Yvelines, 45 Avenue des États-Unis, 78035 Versailles, France
      More by Victor Baldim
    • Nisha Yadav
      Nisha Yadav
      Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Navrangpura, Ahmedabad, 380009 Gujarat, India
      More by Nisha Yadav
      Orcidhttp://orcid.org/0000-0002-4118-7284
    • Nicolas Bia
      Nicolas Bia
      SPECIFIC POLYMERS, ZAC Via Domitia, 150 Avenue des Cocardières, 34160 Castries, France
      More by Nicolas Bia
    • Alain Graillot
      Alain Graillot
      SPECIFIC POLYMERS, ZAC Via Domitia, 150 Avenue des Cocardières, 34160 Castries, France
      More by Alain Graillot
    • Cédric Loubat
      Cédric Loubat
      SPECIFIC POLYMERS, ZAC Via Domitia, 150 Avenue des Cocardières, 34160 Castries, France
      More by Cédric Loubat
    • Sanjay Singh
      Sanjay Singh
      Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Navrangpura, Ahmedabad, 380009 Gujarat, India
      More by Sanjay Singh
      Orcidhttp://orcid.org/0000-0002-6256-7091
    • Ajay S. Karakoti
      Ajay S. Karakoti
      Global Innovative Center for Advanced Nanomaterials (GICAN), Faculty of Engineering and Built Environment (FEBE), The University of Newcastle, Callaghan, NSW 2308, Australia
      More by Ajay S. Karakoti
    • Jean-François Berret*
      Jean-François Berret
      Matière et systèmes complexes, Université de Paris, CNRS, 75013 Paris, France
      *Email: [email protected]
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2020, 12, 37, 42056–42066
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    https://doi.org/10.1021/acsami.0c08778
    Published August 19, 2020
    Copyright © 2020 American Chemical Society
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    Abstract

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    Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be found in superoxide radicals and hydrogen peroxides, which are harmful molecules produced in oxidative stress-associated diseases. Despite the fact that nanoparticle functionalization is mandatory in the context of nanomedicine, the influence of polymer coatings on their enzyme-like catalytic activity is poorly understood. In this work, six polymer-coated cerium oxide nanoparticles are prepared by the association of 7.8 nm cerium oxide cores with two poly(sodium acrylate) and four poly(ethylene glycol) (PEG)-grafted copolymers with different terminal or anchoring end groups, such as phosphonic acids. The superoxide dismutase-, catalase-, peroxidase-, and oxidase-like catalytic activities of the coated nanoparticles were systematically studied. It is shown that the polymer coatings do not affect the superoxide dismutase-like, impair the catalase-like and oxidase-like, and surprisingly improves peroxidase-like catalytic activities of cerium oxide nanoparticles. It is also demonstrated that the particles coated with the PEG-grafted copolymers perform better than the poly(acrylic acid)-coated ones as oxidoreductase-like enzymes, a result that confirms the benefit of having phosphonic acids as anchoring groups at the particle surface.

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.0c08778.

    • Wide-angle X-ray scattering (WAXS) of cerium oxide nanoparticles (Figure S1); X-ray photoelectron spectrometry (XPS) Ce 3d spectra of cerium oxide nanoparticles (Figure S2 and Table S2); copolymer synthesis and characterization using 1H NMR (Figure S3); weight-averaged molecular weight determination of the copolymers obtained from static light scattering (Figure S4); TEM images of polymer-coated cerium oxide nanoparticles (Figure S5); oxidase-like catalytic activity of cerium oxide nanoparticles (Figure S6 and Table S6); calibration for hydroxyl radical measurements in relation with peroxidase-like activity (Figure S7); quantification of hydroxyl radicals (Figure S8) (PDF)

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