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SPECT/CT Imaging of 111Ag for the Preclinical Evaluation of Silver-Based Antimicrobial Nanomedicines

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Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2022, 14, 23, 26382-26393
    Biological and Medical Applications of Materials and Interfaces

    SPECT/CT Imaging of 111Ag for the Preclinical Evaluation of Silver-Based Antimicrobial Nanomedicines
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    • Colin Blackadar
      Colin Blackadar
      Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada
      More by Colin Blackadar
      Orcidhttps://orcid.org/0000-0002-3847-3693
    • Ka-Yee Grace Choi
      Ka-Yee Grace Choi
      Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, Faculty of Science, University of British Columbia, Vancouver, BC V6T1Z4, Canada
      More by Ka-Yee Grace Choi
      Orcidhttps://orcid.org/0000-0002-6320-9915
    • Mary F. Embree
      Mary F. Embree
      University of Missouri Research Reactor Center (MURR), 13513 Research Park Drive, Columbia, Missouri 65211, United States
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    • Heather M. Hennkens
      Heather M. Hennkens
      University of Missouri Research Reactor Center (MURR), 13513 Research Park Drive, Columbia, Missouri 65211, United States
      Department of Chemistry, University of Missouri, 125 Chemistry Building, Columbia, Missouri 65211, United States
      More by Heather M. Hennkens
      Orcidhttps://orcid.org/0000-0002-3283-8751
    • Cristina Rodríguez-Rodríguez
      Cristina Rodríguez-Rodríguez
      Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada
      Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T1Z1, Canada
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      Orcidhttps://orcid.org/0000-0002-3313-4422
    • Robert E. W. Hancock
      Robert E. W. Hancock
      Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, Faculty of Science, University of British Columbia, Vancouver, BC V6T1Z4, Canada
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      Orcidhttps://orcid.org/0000-0001-5989-8503
    • Katayoun Saatchi*
      Katayoun Saatchi
      Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada
      *Email: [email protected]
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      Orcidhttps://orcid.org/0000-0002-5372-6791
    • Urs O. Häfeli*
      Urs O. Häfeli
      Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada
      Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark
      *Email: [email protected]
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      Orcidhttps://orcid.org/0000-0003-0671-4509
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2022, 14, 23, 26382–26393
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    https://doi.org/10.1021/acsami.2c03609
    Published June 2, 2022
    Copyright © 2022 American Chemical Society
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    Abstract

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    With the growing interest in developing silver-based antimicrobials, there is a need to better understand the behavior of silver within biological systems. To address this, we showed that single-photon emission computed tomography (SPECT) is a suitable method to noninvasively image 111Ag-labeled compounds in mice. Formed by neutron irradiation of palladium foil, 111Ag can be rapidly isolated with a high degree of purity and stably incorporated into antimicrobial silver nanoparticles. The imaging showed that nanoparticles are retained in the lungs for up to 48 h following intratracheal instillation, with limited uptake into the systemic circulation or organs of the reticuloendothelial system. Furthermore, in a mouse model of pulmonary Pseudomonas aeruginosa infection, the nanoparticles reduced the bacterial burden by 11.6-fold without inducing the production of pro-inflammatory mediators. Overall, SPECT imaging with 111Ag is a useful tool for noninvasively visualizing the biodistribution of silver-containing compounds in rodents. This knowledge of how silver nanoparticles distribute in vivo can be used to predict their therapeutic efficacy.

    Copyright © 2022 American Chemical Society

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    • Figures showing changes in AgNP antimicrobial activity with storage, the comprehensive biodistribution of [111Ag]AgNPs, PXRD spectrum of AgNPs, separation of silver from palladium, changes in AgNP diameter with storage, the hydrodynamic diameter of AgNPs in different conditions, and changes in AgNP hydrodynamic diameter in different conditions (PDF)

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    This article is cited by 4 publications.

    1. Marianna Tosato, Andrea Gandini, Steffen Happel, Marine Bas, Antonietta Donzella, Aldo Zenoni, Andrea Salvini, Alberto Andrighetto, Valerio Di Marco, Mattia Asti. Chromatographic separation of silver-111 from neutron-irradiated palladium target: toward direct labeling of radiotracers. EJNMMI Radiopharmacy and Chemistry 2023, 8 (1) https://doi.org/10.1186/s41181-023-00232-0
    2. Mulan Li, Ying Liu, Youhuan Gong, Xiaojie Yan, Le Wang, Wenfu Zheng, Hao Ai, Yuliang Zhao. Recent advances in nanoantibiotics against multidrug-resistant bacteria. Nanoscale Advances 2023, 5 (23) , 6278-6317. https://doi.org/10.1039/D3NA00530E
    3. Marianna Tosato, Mattia Asti. Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods. Pharmaceuticals 2023, 16 (7) , 929. https://doi.org/10.3390/ph16070929
    4. Haiyan Huang, Arbab Ali, Yi Liu, Hui Xie, Sana Ullah, Shubham Roy, Zhiyong Song, Bing Guo, Jian Xu. Advances in image-guided drug delivery for antibacterial therapy. Advanced Drug Delivery Reviews 2023, 192 , 114634. https://doi.org/10.1016/j.addr.2022.114634
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2022, 14, 23, 26382–26393
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.2c03609
    Published June 2, 2022
    Copyright © 2022 American Chemical Society
    Request reuse permissions

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