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A Polymer-Based Multichannel Sensor for Rapid Cell-Based Screening of Antibiotic Mechanisms and Resistance Development

Cite this: ACS Appl. Mater. Interfaces 2022, 14, 23, 27515–27522
Publication Date (Web):May 31, 2022
https://doi.org/10.1021/acsami.2c07012
Copyright © 2022 American Chemical Society

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    Abstract

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    Antibiotic resistance presents a critical threat to public health, necessitating the rapid development of novel antibiotics and an appropriate choice of therapeutics to combat refractory bacterial infections. Here, we report a high-throughput polymer-based sensor platform that rapidly (30 min) profiles mechanisms of antibiotic activity. The sensor array features three fluorophore-conjugated polymers that can detect subtle antibiotic-induced phenotypic changes on bacterial surfaces, generating distinct mechanism-based fluorescence patterns. Notably, discrimination of different generations of antibiotic resistance was achieved with high efficiency. This sensor platform combines trainability, simplicity, and rapid screening into a readily translatable platform.

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    • Synthesis of fluorescent polymers, 1H NMR of polymers, preparation of the pathogenic bacteria, generation of resistant bacteria species, and sensing studies (PDF)

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