Targeted Lymphoma Therapy Using a Gold Nanoframework-Based Drug Delivery SystemClick to copy article linkArticle link copied!
- Manpreet BarianaManpreet BarianaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United StatesMore by Manpreet Bariana
- Beilu ZhangBeilu ZhangDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, United StatesMore by Beilu Zhang
- Jingyu SunJingyu SunDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, United StatesMore by Jingyu Sun
- Weiwei WangWeiwei WangDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07303, United StatesMore by Weiwei Wang
- Jinping WangJinping WangDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07303, United StatesMore by Jinping Wang
- Elena CassellaElena CassellaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United StatesMore by Elena Cassella
- Faith MyintFaith MyintCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United StatesMore by Faith Myint
- Shaina A. AnuncioShaina A. AnuncioCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United StatesMore by Shaina A. Anuncio
- Samedy Ouk
- Hsiou-Chi Liou
- Ming TanMing TanDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, Washington, District of Columbia 20057, United StatesMore by Ming Tan
- Hongjun Wang*Hongjun Wang*Email: [email protected]. Tel: +1 (201)-216-5556.Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, United StatesDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07303, United StatesCenter for Healthcare Innovation, Stevens Institute of Technology, Hoboken, New Jersey 07030, United StatesMore by Hongjun Wang
- Johannes L. Zakrzewski*Johannes L. Zakrzewski*Email: [email protected]. Tel: +1 (201)-880-3420.Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United StatesDepartment of Oncology, Georgetown University, Washington, District of Columbia 20057, United StatesDepartment of Pediatrics, Hackensack University Medical Center, Hackensack, New Jersey 07601, United StatesMore by Johannes L. Zakrzewski
Abstract

Precision nanomedicine can be employed as an alternative to chemo- or radiotherapy to overcome challenges associated with the often narrow therapeutic window of traditional treatment approaches, while safely inducing effective, targeted antitumor responses. Herein, we report the formulation of a therapeutic nanocomposite comprising a hyaluronic acid (HA)-coated gold nanoframework (AuNF) delivery system and encapsulated IT848, a small molecule with potent antilymphoma and -myeloma properties that targets the transcriptional activity of nuclear factor kappa B (NF-κB). The porous AuNFs fabricated via a liposome-templated approach were loaded with IT848 and surface-functionalized with HA to formulate the nanotherapeutics that were able to efficiently deliver the payload with high specificity to myeloma and lymphoma cell lines in vitro. In vivo studies characterized biodistribution, pharmacokinetics, and safety of HA-AuNFs, and we demonstrated superior efficacy of HA-AuNF-formulated IT848 vs free IT848 in lymphoma mouse models. Both in vitro and in vivo results affirm that the AuNF system can be adopted for targeted cancer therapy, improving the drug safety profile, and enhancing its efficacy with minimal dosing. HA-AuNF-formulated IT848 therefore has strong potential for clinical translation.
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This article is cited by 5 publications.
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