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Targeted Lymphoma Therapy Using a Gold Nanoframework-Based Drug Delivery System
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    Biological and Medical Applications of Materials and Interfaces

    Targeted Lymphoma Therapy Using a Gold Nanoframework-Based Drug Delivery System
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    • Manpreet Bariana
      Manpreet Bariana
      Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States
    • Beilu Zhang
      Beilu Zhang
      Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, United States
      More by Beilu Zhang
    • Jingyu Sun
      Jingyu Sun
      Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, United States
      More by Jingyu Sun
    • Weiwei Wang
      Weiwei Wang
      Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07303, United States
      More by Weiwei Wang
    • Jinping Wang
      Jinping Wang
      Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07303, United States
      More by Jinping Wang
    • Elena Cassella
      Elena Cassella
      Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States
    • Faith Myint
      Faith Myint
      Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States
      More by Faith Myint
    • Shaina A. Anuncio
      Shaina A. Anuncio
      Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States
    • Samedy Ouk
      Samedy Ouk
      ImmuneTarget Inc., San Diego, California 92121, United States
      More by Samedy Ouk
    • Hsiou-Chi Liou
      Hsiou-Chi Liou
      ImmuneTarget Inc., San Diego, California 92121, United States
    • Ming Tan
      Ming Tan
      Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, Washington, District of Columbia 20057, United States
      More by Ming Tan
    • Hongjun Wang*
      Hongjun Wang
      Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07030, United States
      Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, New Jersey 07303, United States
      Center for Healthcare Innovation, Stevens Institute of Technology, Hoboken, New Jersey 07030, United States
      *Email: [email protected]. Tel: +1 (201)-216-5556.
      More by Hongjun Wang
    • Johannes L. Zakrzewski*
      Johannes L. Zakrzewski
      Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States
      Department of Oncology, Georgetown University, Washington, District of Columbia 20057, United States
      Department of Pediatrics, Hackensack University Medical Center, Hackensack, New Jersey 07601, United States
      *Email: [email protected]. Tel: +1 (201)-880-3420.
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2023, 15, 5, 6312–6325
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    https://doi.org/10.1021/acsami.2c17214
    Published January 26, 2023
    Copyright © 2023 American Chemical Society

    Abstract

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    Precision nanomedicine can be employed as an alternative to chemo- or radiotherapy to overcome challenges associated with the often narrow therapeutic window of traditional treatment approaches, while safely inducing effective, targeted antitumor responses. Herein, we report the formulation of a therapeutic nanocomposite comprising a hyaluronic acid (HA)-coated gold nanoframework (AuNF) delivery system and encapsulated IT848, a small molecule with potent antilymphoma and -myeloma properties that targets the transcriptional activity of nuclear factor kappa B (NF-κB). The porous AuNFs fabricated via a liposome-templated approach were loaded with IT848 and surface-functionalized with HA to formulate the nanotherapeutics that were able to efficiently deliver the payload with high specificity to myeloma and lymphoma cell lines in vitro. In vivo studies characterized biodistribution, pharmacokinetics, and safety of HA-AuNFs, and we demonstrated superior efficacy of HA-AuNF-formulated IT848 vs free IT848 in lymphoma mouse models. Both in vitro and in vivo results affirm that the AuNF system can be adopted for targeted cancer therapy, improving the drug safety profile, and enhancing its efficacy with minimal dosing. HA-AuNF-formulated IT848 therefore has strong potential for clinical translation.

    Copyright © 2023 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.2c17214.

    • HA-AuNF incubation does not impact cell survival (Figure S1); IT848-HA-AuNF treatment does not compromise the viability of healthy cells (Figure S2); and IT848 treatment decreases the density of lymphoma cells in a subcutaneous lymphoma model (Figure S3) (PDF)

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    This article is cited by 5 publications.

    1. Yuanying Zhang, Nan Yang, Ziyi Dong, Jiahui Wu, Rui Liao, Yanling Zhang, Gege Zhang, Mengfei Ren, Feng Wang, Xiaochen Dong, Pingping Liang. Dual-Targeting Biomimetic Nanomaterials for Photo-/Chemo-/Antiangiogenic Synergistic Therapy. ACS Applied Materials & Interfaces 2023, 15 (28) , 33288-33298. https://doi.org/10.1021/acsami.3c03471
    2. Ashruti Pant, Aayushi Laliwala, Sarah A. Holstein, Aaron M. Mohs. Recent advances in targeted drug delivery systems for multiple myeloma. Journal of Controlled Release 2024, 376 , 215-230. https://doi.org/10.1016/j.jconrel.2024.10.003
    3. Danka Cholujova, Zdenka Lukacova Bujnakova, Erika Dutkova, Zuzana Valuskova, Nikoleta Csicsatkova, Katarina Suroviakova, Maria Elisabeth Marinkovicova, Linda Zbellova, Lenka Koklesova, Jan Sedlak, Teru Hideshima, Kenneth C. Anderson, Jana Jakubikova. Exploring the anti-myeloma potential of composite nanoparticles As4S4/Fe3O4: Insights from in vitro, ex vivo and in vivo studies. Nanomedicine: Nanotechnology, Biology and Medicine 2024, 62 , 102777. https://doi.org/10.1016/j.nano.2024.102777
    4. Huiyang Fu, Yinfeng Chen, Qingyao Fu, Qingqing Lv, Jing Zhang, Yang Yang, Peng Tan, Xiaozhe Wang, Ying Yang, Zhenlong Wu. From conventional to cutting-edge: Exosomes revolutionizing nano-drug delivery systems. Chemical Engineering Journal 2024, 500 , 156685. https://doi.org/10.1016/j.cej.2024.156685
    5. Sourour Idoudi, Roua Ismail, Ousama Rachid, Abdelbary Elhissi, Alaaldin M. Alkilany. The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites. Journal of Nanotheranostics 2023, 4 (3) , 201-227. https://doi.org/10.3390/jnt4030010

    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2023, 15, 5, 6312–6325
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.2c17214
    Published January 26, 2023
    Copyright © 2023 American Chemical Society

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