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Macroencapsulation Device with Anti-inflammatory Membrane Modification Enhances Long-Term Viability and Function of Transplanted β Cells

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Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2024, 16, 51, 70218-70230
    Biological and Medical Applications of Materials and Interfaces

    Macroencapsulation Device with Anti-inflammatory Membrane Modification Enhances Long-Term Viability and Function of Transplanted β Cells
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    • MinJi Park
      MinJi Park
      Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
      More by MinJi Park
    • Hyun Lee
      Hyun Lee
      Research Institute of Intelligent Manufacturing & Materials Technology, Korea Institute of Industrial Technology, Incheon 21999, Republic of Korea
      More by Hyun Lee
    • Yerim Jang
      Yerim Jang
      Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
      KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea
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    • Min Ji Kim
      Min Ji Kim
      Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
      More by Min Ji Kim
    • Younghak Cho
      Younghak Cho
      Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
      More by Younghak Cho
    • Sophie S. Liu
      Sophie S. Liu
      Department of Chemical Engineering, University of Toronto, Toronto ON M5S 3E5, Canada
      More by Sophie S. Liu
    • JungEun Lee
      JungEun Lee
      Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
      More by JungEun Lee
    • Surim Shim
      Surim Shim
      Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
      More by Surim Shim
    • Hyun-Do Jung*
      Hyun-Do Jung
      Division of Materials Science and Engineering, Hanyang University, Seoul 04763, Republic of Korea
      *Email: [email protected]
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      Orcidhttps://orcid.org/0000-0001-8632-7431
    • Hyejeong Seong*
      Hyejeong Seong
      Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
      Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea
      *Email: [email protected]
      More by Hyejeong Seong
      Orcidhttps://orcid.org/0000-0002-9877-296X
    • Kisuk Yang*
      Kisuk Yang
      Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
      Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
      Research Center for Bio Materials & Process Development, Incheon National University, Incheon 22012, Republic of Korea
      *Email: [email protected]
      More by Kisuk Yang
      Orcidhttps://orcid.org/0000-0002-2724-5222
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2024, 16, 51, 70218–70230
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    https://doi.org/10.1021/acsami.4c14057
    Published December 12, 2024
    Copyright © 2024 American Chemical Society
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    Abstract

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    Treating type 1 diabetes (T1D) through β-cell macroencapsulation is a promising long-term solution, but it faces challenges such as immune-mediated fibrosis on the capsule surface, which impairs cell functionality and compromises longevity and effectiveness. This study presents an approach for including an anti-inflammatory molecule on the macroencapsulation device (MED) using initiated chemical vapor deposition for the surface modification of poly(tetrafluoroethylene) (PTFE) membranes. The surface-modified MEDs significantly reduced fibrosis, improved β-cell viability and functionality, and promoted M2 macrophage polarization, which is associated with anti-inflammatory effects. This MED displayed improved glycemic control in a streptozotocin-induced diabetic mouse model for 45 days. The findings underscore the potential of surface-modified MEDs for improving T1D management by mitigating inflammation and enhancing the therapeutic efficacy of β-cell encapsulation.

    Copyright © 2024 American Chemical Society

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.4c14057.

    • Gross view of MED, XPS analysis of surfaces, SEM-based pore size quantification, diffusion test for dextran (4.0 kDa) through PTFE membranes, M2 macrophage polarization analysis, gene expression analysis of anti/pro-apoptotic and oxygen-responsive markers in MIN6, and measurement of body weight change in diabetes-induced mice (PDF)

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2024, 16, 51, 70218–70230
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.4c14057
    Published December 12, 2024
    Copyright © 2024 American Chemical Society
    Request reuse permissions

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