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Robust Anticorrosive Polymer Thin Film for Reliable Protection of Ingestible Devices

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Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2024, 16, 48, 66458-66469
    Applications of Polymer, Composite, and Coating Materials

    Robust Anticorrosive Polymer Thin Film for Reliable Protection of Ingestible Devices
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    • Booseok Jeong
      Booseok Jeong
      Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
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    • Seo Jin Kim
      Seo Jin Kim
      Department of Nano Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
      Department of Nano Science and Technology, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
      More by Seo Jin Kim
      Orcidhttps://orcid.org/0000-0002-3641-1616
    • Jemin Yeun
      Jemin Yeun
      Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
      More by Jemin Yeun
    • Jihoon Lim
      Jihoon Lim
      Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
      More by Jihoon Lim
    • Nahyun Park
      Nahyun Park
      Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
      More by Nahyun Park
    • Aram Bae
      Aram Bae
      Center for NanoBio Development, National NanoFab Center, Daejeon 34141, Republic of Korea
      More by Aram Bae
    • Jueun Kim
      Jueun Kim
      Department of Chemical Engineering, Kangwon National University, Samcheok 25913, Republic of Korea
      More by Jueun Kim
    • Oh Seok Kwon
      Oh Seok Kwon
      Department of Nano Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
      SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
      More by Oh Seok Kwon
    • Bong Gill Choi*
      Bong Gill Choi
      Department of Chemical Engineering, Kangwon National University, Samcheok 25913, Republic of Korea
      *Email: [email protected]
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      Orcidhttps://orcid.org/0000-0002-5452-4091
    • Sung Gap Im*
      Sung Gap Im
      Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
      KI for NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
      *Email: [email protected]
      More by Sung Gap Im
      Orcidhttps://orcid.org/0000-0002-2802-6398
    • Kyoung G. Lee*
      Kyoung G. Lee
      Center for NanoBio Development, National NanoFab Center, Daejeon 34141, Republic of Korea
      *Email: [email protected]
      More by Kyoung G. Lee
      Orcidhttps://orcid.org/0000-0003-2691-0910
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2024, 16, 48, 66458–66469
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    https://doi.org/10.1021/acsami.4c14344
    Published November 19, 2024
    Copyright © 2024 American Chemical Society
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    Abstract

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    Ingestible devices (ID) provide a safe and noninvasive method for monitoring, diagnosing, and delivering drugs to specific sites in the human body, particularly within the gastrointestinal (GI) tract. However, the GI environment is highly acidic and humid, which can cause IDs to fail, and their corrosion in the acidic environment can cause leaching of toxic metal ions, thereby substantially limiting their long-term use. Thus, an efficient method is required to protect IDs, especially in the chemically and mechanically harsh GI environment. However, an anticorrosive polymer coating that can safeguard IDs in the GI environment without delamination or performance degradation has not been developed to date. The protective layer must satisfy several critical requirements, e.g., high biocompatibility, mechanical durability, and superior anticorrosion performance. This paper reports a highly cross-linked but submicron-thick siloxane-based anticorrosive polymer thin film that can be deposited directly onto IDs without damaging them. The 500 nm-thick cross-linked polymer coating demonstrates exceptional corrosion resistance and chemical and mechanical stability in the GI environment without cytotoxicity. A printed circuit board (PCB) coated with the developed ultrathin protective film sustained performance after exposure to a pH 1.00 phosphate buffered saline solution at 37 °C for 72 h without leaching of metal ions. The ID continued to operate effectively under such challenging conditions; thus, the developed film is suitable for applications that require prolonged functionality, e.g., diagnostics, drug delivery, and continuous health monitoring in the GI tract.

    Copyright © 2024 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.4c14344.

    • FT-IR spectra of V3D3 monomer and polymer (Figure S1); AFM images of bare Cu and pV3D3-coated Cu after corrosion test in pH 1.00 PBS solution (Figure S2); Tafel polarization curves and fitted lines and parameters of bare Cu and pV3D3-coated Cu (Figure S3); phase diagrams of bare Cu and pV3D3-coated Cu (Figure S4); equivalent circuits and fitted Nyquist plots of bare Cu and pV3D3-coated Cu (Figure S5); thickness and refractive index change of the pV3D3 coated Si wafer (Figure S6); water contact angle and FT-IR analysis data of the pV3D3 polymer before and after exposure to solvents (Figure S7); images of the cross-cut pV3D3-coated Si wafer before and after 5 rounds of tape peel-off tests (Figure S8); gas chromatography analysis data for verifying the nonleaching properties of pV3D3 polymer (Figure S9); images of NHDF cells cultured on pV3D3-coated TCPS (Figure S10); SEM images of bare Cu and pV3D3-coated Cu after corrosion test in pH 1.00 PBS solution (Figure S11); Tafel plot parameters of Cu and pV3D3-coated Cu (Table S1); EIS parameters of Cu and pV3D3-coated Cu (Table S2) (PDF)

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    This article is cited by 1 publications.

    1. Zhaodong Wang. Ingestible electrochemical sensors: Emerging tools for gastrointestinal disease detection and monitoring. International Journal of Electrochemical Science 2025, 20 (3) , 100952. https://doi.org/10.1016/j.ijoes.2025.100952
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2024, 16, 48, 66458–66469
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.4c14344
    Published November 19, 2024
    Copyright © 2024 American Chemical Society
    Request reuse permissions

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