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Electrospun Polyhydroxybutyrate/Poly(ε-caprolactone)/58S Sol–Gel Bioactive Glass Hybrid Scaffolds with Highly Improved Osteogenic Potential for Bone Tissue Engineering

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† Institute of Polymer Materials, University of Erlangen-Nuremberg, Martensstrasse 7, 91058 Erlangen, Germany
‡ Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany
§ Institute of Advanced Materials for Nano-Bio Applications, Wenzhou Medical University, 270 Xueyuan Xi Road, Wenzhou, Zhejiang 325027, China
*[email protected] (Judith A. Roether).
*[email protected] (Qingqing Yao).
Cite this: ACS Appl. Mater. Interfaces 2016, 8, 27, 17098–17108
Publication Date (Web):June 13, 2016
https://doi.org/10.1021/acsami.6b03997
Copyright © 2016 American Chemical Society
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    Abstract

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    Electrospinning of biopolymer and inorganic substances is one of the efficient ways to combine various advantageous properties in one single fibrous structure with potential for tissue engineering applications. In the present study, to integrate the high stiffness of polyhydroxybutyrate (PHB), the flexibility of poly(ε-caprolactone) (PCL) and the bioactivity of 58S bioactive glass, PHB/PCL/58S sol–gel bioactive glass hybrid scaffolds were fabricated using combined electrospinning and sol–gel method. Physical features such as fiber diameter distribution, mechanical strength and Young’s modulus were characterized thoroughly. FTIR analysis demonstrated the successful incorporation of 58S bioactive glass into the blend polymers, which greatly improved the hydrophilicity of PHB/PCL fibermats. The primary biological response of MG-63 osteoblast-like cells on the prepared fibrous scaffolds was evaluated, proving that the 58S glass sol containing hybrid scaffold were not only favorable to MG-63 cell adhesion but also slightly enhanced cell viability and significantly increased alkaline phosphate activity .

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