Three-Dimensional Porous Sponges from Collagen BiowastesClick to copy article linkArticle link copied!
- Meiyazhagan Ashokkumar
- Alin Cristian Chipara
- Narayanan Tharangattu Narayanan
- Ayyappan Anumary
- Radhakrishnan Sruthi
- Palanisamy Thanikaivelan
- Robert Vajtai
- Sendurai A. Mani
- Pulickel M. Ajayan
Abstract

Three-dimensional, functional, and porous scaffolds can find applications in a variety of fields. Here we report the synthesis of hierarchical and interconnected porous sponges using a simple freeze-drying technique, employing collagen extracted from animal skin wastes and superparamagnetic iron oxide nanoparticles. The ultralightweight, high-surface-area sponges exhibit excellent mechanical stability and enhanced absorption of organic contaminants such as oils and dye molecules. Additionally, these biocomposite sponges display significant cellular biocompatibility, which opens new prospects in biomedical uses. The approach highlights innovative ways of transforming biowastes into advanced hybrid materials using simple and scalable synthesis techniques.
Cited By
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by ACS Publications if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
This article is cited by 32 publications.
- Jian Zhang, Hua Yuan, Lingyan Li, Jiaqi Zhang, Manting Wang, Yuan Le, Jian-Feng Chen. Hydrogel from Chrome Shavings as a Sustainable, Highly Sensitive Ionic Skin for Pressure Sensing. ACS Sustainable Chemistry & Engineering 2022, 10
(25)
, 8172-8183. https://doi.org/10.1021/acssuschemeng.2c01421
- AshokKumar Meiyazhagan, Amir Aliyan, Anumary Ayyappan, Ines Moreno-Gonzalez, Sandhya Susarla, Sadegh Yazdi, Karina Cuanalo-Contreras, Valery N. Khabashesku, Robert Vajtai, Angel A. Martí, Pulickel M. Ajayan. Soft-Lithographic Patterning of Luminescent Carbon Nanodots Derived from Collagen Waste. ACS Applied Materials & Interfaces 2018, 10
(42)
, 36275-36283. https://doi.org/10.1021/acsami.8b13114
- Berhanu Telay Mekonnen, Murali Ragothaman, and Thanikaivelan Palanisamy . Bifunctional Hybrid Composites from Collagen Biowastes for Heterogeneous Applications. ACS Omega 2017, 2
(8)
, 5260-5270. https://doi.org/10.1021/acsomega.7b01011
- Xuechuan Wang, Xiaoxiao Guo, Haijun Wang, and Peiying Guo . Effect of Linear-Hyperbranched Amphiphilic Phosphate Esters on Collagen Fibers. Journal of Agricultural and Food Chemistry 2017, 65
(1)
, 104-116. https://doi.org/10.1021/acs.jafc.6b04482
- Hua Yuan, Manting Wang, Jiaqi Zhang, Jiexin Wang, Yuan Le. Hydrogels from chrome shavings for a highly sensitive capacitive pressure sensor. Journal of Materials Chemistry A 2024, 12
(16)
, 9797-9805. https://doi.org/10.1039/D4TA00702F
- Cihang Chen, Ziyu Wu, Yufu Wang, Hong Wei, Baiyu Li. Oil/water separation through dual-channeled superhydrophobic/underwater superoleophobic meshes toward continuous processes. Separation Science and Technology 2024, 59
(6-9)
, 1068-1082. https://doi.org/10.1080/01496395.2024.2362737
- Deepti Rekha Sahoo, Trinath Biswal. Study of antibacterial and mechanical properties of poly(
methyl methacrylate‐co‐acrylic acid
)/hydroxyapatite biocomposite by using artificial neural network approach. SPE Polymers 2024, 5
(2)
, 169-181. https://doi.org/10.1002/pls2.10117
- Mani Malam Ahmad. Abattoir waste valorization: potential utilization of by-products into value-added chains. 2024, 267-280. https://doi.org/10.1016/B978-0-443-15958-9.00016-2
- Baskaran Ramalingam, Sujoy K. Das. Biomimetic strategy for fabrication of bifunctional graphene oxide-biomaterial aerogel as highly porous antifouling material for oil/water separation. Chemical Engineering Journal 2023, 475 , 145906. https://doi.org/10.1016/j.cej.2023.145906
- Bishwambhar Mishra, Yugal Kishore Mohanta, C. Nagendranatha Reddy, S. Deepak Mohan Reddy, Sanjeeb Kumar Mandal, Rajasri Yadavalli, Hemen Sarma. Valorization of agro-industrial biowaste to biomaterials: An innovative circular bioeconomy approach. Circular Economy 2023, 2
(3)
, 100050. https://doi.org/10.1016/j.cec.2023.100050
- Hua Yuan, Jian Zhang, Jiaqi Zhang, Manting Wang, Jiexin Wang, Yuan Le. A “soft and hard” bioinspired hydrogel for enhanced pressure sensing. Journal of Materials Chemistry C 2023, 11
(31)
, 10562-10572. https://doi.org/10.1039/D3TC01223A
- Martín Caldera‐Villalobos, Jesús Alejandro Claudio‐Rizo, Denis Aidée Cabrera‐Munguía, Nidia Guadalupe Burciaga‐Montemayor. Biobased hydrogels and their composite containing MgMOF74 for the removal of textile dyes and wastewater treatment. Water Environment Research 2022, 94
(9)
https://doi.org/10.1002/wer.10785
- Erlantz Lizundia, Francesca Luzi, Debora Puglia. Organic waste valorisation towards circular and sustainable biocomposites. Green Chemistry 2022, 24
(14)
, 5429-5459. https://doi.org/10.1039/D2GC01668K
- M. Harkat, S. Alleg, R. Chemam, N. Moutia, K. Khirouni, E. Dhahri. Structure and Electric Characterizations of the Derived Nanocrystalline Hydroxyapatite from Strombidae Strombus Seashells. Arabian Journal for Science and Engineering 2022, 47
(6)
, 7693-7706. https://doi.org/10.1007/s13369-021-06556-w
- Kaivalya Patel, Dureem Munir, Rafael M. Santos. Beneficial use of animal hides for abattoir and tannery waste management: a review of unconventional, innovative, and sustainable approaches. Environmental Science and Pollution Research 2022, 29
(2)
, 1807-1823. https://doi.org/10.1007/s11356-021-17101-5
- S. Nagaraj, K. Cheirmadurai, P. Thanikaivelan. Visible-light active collagen-TiO2 nanobio-sponge for water remediation: A sustainable approach. Cleaner Materials 2021, 1 , 100011. https://doi.org/10.1016/j.clema.2021.100011
- Shohei Nishimura, Neel Narayan, Onur Sahin, Ashleigh D. Smith McWilliams, Kristen A. Miller, Devashish Salpekar, Zixing Wang, Jarin Joyner, Angel A. Martí, Robert Vajtai, Meiyazhagan Ashokkumar, Pulickel M. Ajayan. Luminescent hybrid biocomposite films derived from animal skin waste. Carbon Trends 2021, 4 , 100059. https://doi.org/10.1016/j.cartre.2021.100059
- Yuchen Wang, Yunhong Wei, Boya Wang, Peng Jing, Yin Zhang, Yun Zhang, Qian Wang, Hao Wu. Bio-assisted engineering of hierarchical porous carbon nanofiber host in-situ embedded with iron carbide nanocatalysts toward high-performance Li–S batteries. Carbon 2021, 177 , 60-70. https://doi.org/10.1016/j.carbon.2021.02.073
- Meiyazhagan Ashokkumar, Pulickel M. Ajayan. Materials science perspective of multifunctional materials derived from collagen. International Materials Reviews 2021, 66
(3)
, 160-187. https://doi.org/10.1080/09506608.2020.1750807
- Cheirmadurai Kalirajan, Thanikaivelan Palanisamy. Silica microsphere–resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats. Biomaterials Science 2020, 8
(6)
, 1622-1637. https://doi.org/10.1039/C9BM01089K
- Cheirmadurai Kalirajan, Pearlin Hameed, Nagaraj Subbiah, Thanikaivelan Palanisamy. A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation. Scientific Reports 2019, 9
(1)
https://doi.org/10.1038/s41598-018-37758-2
- Chunping Xu, Mahmoud Nasrollahzadeh, Maurizio Selva, Zahra Issaabadi, Rafael Luque. Waste-to-wealth: biowaste valorization into valuable bio(nano)materials. Chemical Society Reviews 2019, 48
(18)
, 4791-4822. https://doi.org/10.1039/C8CS00543E
- Krister Gjestvang Grønlien, Mona Elisabeth Pedersen, Karen Wahlstrøm Sanden, Vibeke Høst, Jan Karlsen, Hanne Hjorth Tønnesen. Collagen from Turkey (Meleagris gallopavo) tendon: A promising sustainable biomaterial for pharmaceutical use. Sustainable Chemistry and Pharmacy 2019, 13 , 100166. https://doi.org/10.1016/j.scp.2019.100166
- Nongping Zhong, Tao Dong, Zhongchun Chen, Yongwei Guo, Zhengzhong Shao, Xia Zhao. A novel 3D-printed silk fibroin-based scaffold facilitates tracheal epithelium proliferation in vitro. Journal of Biomaterials Applications 2019, 34
(1)
, 3-11. https://doi.org/10.1177/0885328219845092
- Bishnupriya Nayak, Pramila K. Misra. Recognition of the surface characteristics and electrical properties of a nanocrystalline hydroxyapatite synthesized from Pila globosa shells for versatile applications. Materials Chemistry and Physics 2019, 230 , 187-196. https://doi.org/10.1016/j.matchemphys.2019.03.068
- Peng Shi, Xingkang Hu, Yiting Wang, Ming Duan, Shenwen Fang, Wenjuan Chen. A PEG-tannic acid decorated microfiltration membrane for the fast removal of Rhodamine B from water. Separation and Purification Technology 2018, 207 , 443-450. https://doi.org/10.1016/j.seppur.2018.06.075
- . Porous Polymers by Ice Templating. 2018, 103-139. https://doi.org/10.1002/9783527807390.ch4
- Feng-Li He, Da-Wei Li, Jin He, Yang-Yang Liu, Fiaz Ahmad, Ya-Li Liu, Xudong Deng, Ya-Jing Ye, Da-Chuan Yin. A novel layer-structured scaffold with large pore sizes suitable for 3D cell culture prepared by near-field electrospinning. Materials Science and Engineering: C 2018, 86 , 18-27. https://doi.org/10.1016/j.msec.2017.12.016
- Justyna Kozlowska, Natalia Stachowiak, Alina Sionkowska. Collagen/Gelatin/Hydroxyethyl Cellulose Composites Containing Microspheres Based on Collagen and Gelatin: Design and Evaluation. Polymers 2018, 10
(4)
, 456. https://doi.org/10.3390/polym10040456
- Sylvain Deville. Ice-Templated Materials: Polymers, Ceramics, Metals and Their Composites. 2017, 253-350. https://doi.org/10.1007/978-3-319-50515-2_5
- Sylvain Deville. Properties and Applications of Ice-Templated Materials. 2017, 439-548. https://doi.org/10.1007/978-3-319-50515-2_7
- Ragothaman Murali, Palanisamy Thanikaivelan, Kalirajan Cheirmadurai. Melatonin in functionalized biomimetic constructs promotes rapid tissue regeneration in Wistar albino rats. Journal of Materials Chemistry B 2016, 4
(35)
, 5850-5862. https://doi.org/10.1039/C6TB01221C
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.