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Dynamically Arranging Gold Nanoparticles on DNA Origami for Molecular Logic Gates

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† School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, China
‡ Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University, Beijing 100871, China
§ Key Laboratory of Advanced Design and Intelligent Computing, Dalian University, Ministry of Education, Dalian 116622, China
*E-mail: [email protected] (Q.Z.).
*E-mail: [email protected] (C.Z.).
Cite this: ACS Appl. Mater. Interfaces 2016, 8, 34, 22451–22456
Publication Date (Web):August 9, 2016
https://doi.org/10.1021/acsami.6b04992
Copyright © 2016 American Chemical Society
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    In molecular engineering, DNA molecules have been extensively studied owing to their capacity for accurate structural control and complex programmability. Recent studies have shown that the versatility and predictability of DNA origami make it an excellent platform for constructing nanodevices. In this study, we developed a strand-displacing strategy to selectively and dynamically release specific gold nanoparticles (AuNPs) on a rectangular DNA origami. A set of DNA logic gates (“OR”, “AND”, and “three-input majority gate”) were established based on this strategy, in which computing results were identified by disassembly between the AuNPs and DNA origami. The computing results were detected using experimental approaches such as gel electrophoresis and transmission electron microscopy (TEM). This method can be used to assemble more complex nanosystems and may have potential applications for molecular engineering.

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